Esther Larrea

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Carmen Palomino-Cano, M. Carmen Mera-Delgado, Esther Moreno, Esther Larrea et autres

ABSTRACT Cutaneous leishmaniasis (CL) remains difficult to treat because Leishmania parasites persist within dermal macrophages and suppress their microbicidal activity, promoting chronic infection. Toll‐like receptor (TLR) agonists can restore macrophage effector functions, but their therapeutic use is limited by systemic toxicity. Here, …

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Leishmanicidal Action of the Peptides 19-4LF, 19-2.5 and 19-2.5LF Topically Administered on Cutaneous Lesions Caused by Leishmania major

Rima El-Dirany, Paolo Ginatta, Celia Fernández-Rubio, Aroia Burguete-Mikeo et autres

Background/Objectives: Antimicrobial peptides (AMPs) represent a promising class of therapeutics with diverse biological functions, including antibacterial, anti-fungal, anti-parasitic and anti-tumoral activities. Previous works demonstrated the successful repurposing of the two synthetic AMPs 19-2.5 and 19-4LF for cutaneous leishmaniasis, when the compounds were …

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Fluidity as a key determinant of stability in PEGylated lipid nanoparticles loaded with a TLR7 agonist

Carmen Palomino-Cano, M. Carmen Mera-Delgado, Ramón Pons, Esther Ramírez Moreno et autres

TLR7 agonists are low molecular weight immunomodulators that can rapidly diffuse from the site of administration, often leading to undesired systemic inflammatory effects. To mitigate toxicity and broaden therapeutic applicability, imiquimod (IMQ), a widely used TLR7 agonist, was encapsulated in lipid-based nanocarriers …

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The Role of BRCT Domain from LmjPES in Leishmania major Pathogenesis

Esther Larrea, José Peña Guerrero, Celia Fernández-Rubio, Aroia Burguete-Mikeo et autres

Leishmaniasis is caused by protozoan parasites from the genus Leishmania and remains one of the major threats to global health, impacting millions of people worldwide as well as animals including dogs. Several treatments have been used for managing leishmaniasis; nevertheless, drug resistance …

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Fluidity as a key determinant of stability in PEGylated lipid nanoparticles loaded with a TLR7 agonist

Carmen Palomino-Cano, M. Carmen Mera-Delgado, Ramón Pons, Esther Ramírez Moreno et autres

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Repurposing the Antibacterial Agents Peptide 19-4LF and Peptide 19-2.5 for Treatment of Cutaneous Leishmaniasis

Rima El-Dirany, Celia Fernández-Rubio, José Peña Guerrero, Esther Ramírez Moreno et autres

The lack of safe and cost-effective treatments against leishmaniasis highlights the urgent need to develop improved leishmanicidal agents. Antimicrobial peptides (AMPs) are an emerging category of therapeutics exerting a wide range of biological activities such as anti-bacterial, anti-fungal, anti-parasitic and anti-tumoral. In …

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The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells

Esther Larrea, Celia Fernández-Rubio, José Peña Guerrero, Elizabeth Guruceaga et autres

Around 15% of cancer cases are attributable to infectious agents. Epidemiological studies suggest that an association between leishmaniasis and cancer does exist. Recently, the homologue of PES1 in Leishmania major (LmjPES) was described to be involved in parasite infectivity. Mammalian PES1 protein …

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Effect of topical berberine in murine cutaneous leishmaniasis lesions

Alba Calvo, Esther Ramírez Moreno, Irati Aldalur, Carmen Sanmartín et autres

OBJECTIVES: More effective topical treatments remain an unmet need for the localized forms of cutaneous leishmaniasis (CL). The aim of this study was to evaluate the efficacy and safety of a topical berberine cream in BALB/c mice infected with Leishmania major parasites. …

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In Leishmania major, the Homolog of the Oncogene PES1 May Play a Critical Role in Parasite Infectivity

Miriam Algarabel, Celia Fernández-Rubio, Kateřina Musilová, José Peña Guerrero et autres

Leishmaniasis is a neglected tropical disease caused by Leishmania spp. The improvement of existing treatments and the discovery of new drugs remain ones of the major goals in control and eradication of this disease. From the parasite genome, we have identified the …

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Changes in the nanoparticle uptake and distribution caused by an intramacrophagic parasitic infection

Alba Calvo, Esther Ramírez Moreno, Unai Clemente, Enma Perez-Chauca et autres

-glycolic nanoparticles (PLGA NPs), as this parasitic infection produces morphological alterations in liver, spleen and bone marrow, organs highly involved in NP sequestration. The results showed that the magnitude of the effect was specific for each organ and type of NP. With …

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LmjF.22.0810 from Leishmania major Modulates the Th2-Type Immune Response and Is Involved in Leishmaniasis Outcome

Andrés Vacas, Celia Fernández-Rubio, Esther Larrea, José Peña Guerrero et autres

A novel serine/threonine protein kinase, LmjF.22.0810, was recently described in Leishmania major. After generating an L. major cell line overexpressing LmjF.22.0810 (named LmJ3OE), the ability of this novel protein to modulate the Th2-type immune response was analyzed. Our results suggest that the …

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Berberine-Loaded Liposomes for the Treatment of Leishmania infantum-Infected BALB/c Mice

Alba Calvo, Esther Ramírez Moreno, Esther Larrea, Carmen Sanmartín et autres

Berberine (BER)—an anti-inflammatory quaternary isoquinoline alkaloid extracted from plants—has been reported to have a variety of biologic properties, including antileishmanial activity. This work addresses the preparation of BER-loaded liposomes with the aim to prevent its rapid liver metabolism and improve the drug …

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