Vicky Ury‐Thiery

Agrégation in vitro de la protéine amyloïde Tau et étude de son impact sur des modèles membranaires par différentes méthodes biophysiques

Vicky Ury‐Thiery

Les maladies neurodégénératives, telles que les maladies d'Alzheimer et de Parkinson, affectent les fonctions cognitives et motrices. Elles se caractérisent par une perte progressive de neurones, sans possibilité de régénération. Avec le vieillissement de la population, ces pathologies, principalement liées à l'âge, …

fr (code pays fourni par la source)

Interaction of full-length Tau with negatively charged lipid membranes leads to polymorphic aggregates

Vicky Ury‐Thiery, Yann Fichou, Isabel D. Alves, Michaël Molinari et autres

in the micromolar range, indicating the deposition of a thick protein layer. Atomic force microscopy (AFM) real-time imaging allows the observation of partial lipid solubilization and the deposition of polymorphic aggregates in the form of thick patches and fibrillary structures resembling amyloid …

fr (code pays fourni par la source)

Chemical Imaging of RNA‐Tau Amyloid Fibrils at the Nanoscale Using Tip‐Enhanced Raman Spectroscopy

Gary Sean Cooney, David Talaga, Vicky Ury‐Thiery, Yann Fichou et autres

In the presence of cofactors, tau protein can form amyloid deposits in the brain which are implicated in many neurodegenerative disorders. Heparin, lipids, and RNA are used to recreate tau aggregates in vitro from recombinant protein. However, the mechanism of interaction of …

fr (code pays fourni par la source)

Chemical Imaging of RNA‐Tau Amyloid Fibrils at the Nanoscale Using Tip‐Enhanced Raman Spectroscopy

Gary Sean Cooney, David Talaga, Vicky Ury‐Thiery, Yann Fichou et autres

Abstract In the presence of cofactors, tau protein can form amyloid deposits in the brain which are implicated in many neurodegenerative disorders. Heparin, lipids, and RNA are used to recreate tau aggregates in vitro from recombinant protein. However, the mechanism of interaction …

fr (code pays fourni par la source)

Studying the incorporation of polyA cofactor into Tau fibrils using Total Internal Reflection Tip-Enhanced Raman Spectroscopy

Cooney, Gary, S, David Talaga, Vicky Ury‐Thiery, Yann Fichou et autres

International audience

Tip-Enhanced Raman Spectroscopy of Tau fibrils: Measurement and Chemometric Analysis

Cooney, Gary, S, David Talaga, Vicky Ury‐Thiery, Yann Fichou et autres

International audience

Total Internal Reflection Tip-Enhanced Raman Spectroscopy of Tau Fibrils

David Talaga, Gary S. Cooney, Vicky Ury‐Thiery, Yann Fichou et autres

Total internal reflection tip-enhanced Raman spectroscopy (TIR-TERS) has recently emerged as a promising technique for noninvasive nanoscale chemical characterization of biomolecules. We demonstrate that the TERS enhancement achieved in this experimental configuration is nearly 30 times higher than that in linear polarization …

fr (code pays fourni par la source)

Small RNA-Seq reveals novel miRNAs shaping the transcriptomic identity of rat brain structures

Anaïs Soula, Mélissa Valere, María José López‐González, Vicky Ury‐Thiery et autres

In the central nervous system (CNS), miRNAs are involved in key functions, such as neurogenesis and synaptic plasticity. Moreover, they are essential to define specific transcriptomes in tissues and cells. However, few studies were performed to determine the miRNome of the different …

fr (code pays fourni par la source)