Rikardo Xhemalaj

Renin–angiotensin system activation and oxidative stress in hospitalized COVID-19 patients: a single-centre prospective observational study

Davide Eleuteri, Filippo Maria Del Tedesco, F Silvia, Caterina Tucciariello et autres

BACKGROUND: The renin-angiotensin system (RAS) plays a critical role in vascular homeostasis and inflammation, and its dysregulation has been implicated in the pathophysiology of COVID-19. We investigated the dynamics of RAS peptides and markers of endothelial dysfunction in relation to respiratory disease …

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Viscoelastic Hemostatic Assays in the Management of Trauma-Induced Coagulopathy: A Clinical Update

Daniele Natalini, Rikardo Xhemalaj, Simone Carelli

The recognition of trauma-induced coagulopathy (TIC) as an endogenous response to traumatic injuries rather than a consequence of therapeutic interventions has shifted the clinical approach toward an early and physiologically based hemostatic resuscitation. Prompt identification and correction of fibrinolysis and fibrinogen level …

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Prognostic value of serial (1,3)-β-d-glucan measurements in ICU patients with invasive candidiasis

Simone Carelli, Brunella Posteraro, Riccardo Torelli, Elena De Carolis et autres

BACKGROUND: To determine whether a decrease in serum (1,3)-β-D-glucan (BDG) was associated with reduced mortality and to investigate the performance of BDG downslope in predicting clinical outcome in invasive candidiasis. METHODS: Observational cohort study in ICU patients over a ten-year period (2012-2022) …

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High-dose colistin pharmacokinetics in critically ill patients receiving continuous renal replacement therapy

Gennaro De Pascale, Lucia Lisi, Salvatore Lucio Cutuli, Carlotta Marinozzi et autres

Colistin, administered as intravenous colistimethate (CMS), is still used in the critical care setting and current guidelines recommend high dosage CMS in patients undergoing continuous renal replacement therapy (CRRT). Due to the paucity of real-life data, we aimed to describe colistin pharmacokinetic/pharmacodynamic …

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Clinical features and 28-day mortality predictors of vaccinated patients admitted to a COVID-19 ICU hub in Italy

Claudia Stella, Cecilia Berardi, Annalisa Chiarito, Veronica Gennenzi et autres

Abstract Background COVID-19 vaccination has been proved to be effective in preventing hospitalization and illness progression, even though data on mortality of vaccinated patients in the intensive care unit (ICU) are conflicting. The aim of this study was to investigate the characteristics …

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Remdesivir plus Dexamethasone in COVID-19: A cohort study of severe patients requiring high flow oxygen therapy or non-invasive ventilation

Gennaro De Pascale, Salvatore Lucio Cutuli, Simone Carelli, Rikardo Xhemalaj et autres

INTRODUCTION: Remdesivir and Dexamethasone represent the cornerstone of therapy for critically ill patients with acute hypoxemic respiratory failure caused by Coronavirus Disease 2019 (COVID-19). However, clinical efficacy and safety of concomitant administration of Remdesivir and Dexamethasone (Rem-Dexa) in severe COVID-19 patients on …

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Staphylococcus aureus ventilator-associated pneumonia in patients with COVID-19: clinical features and potential inference with lung dysbiosis

Gennaro De Pascale, Flavio De Maio, Simone Carelli, Giulia De Angelis et autres

Abstract Background Hospitalized patients with COVID-19 admitted to the intensive care unit (ICU) and requiring mechanical ventilation are at risk of ventilator-associated bacterial infections secondary to SARS-CoV-2 infection. Our study aimed to investigate clinical features of Staphylococcus aureus ventilator-associated pneumonia (SA-VAP) and, …

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COVID-19 influences lung microbiota dynamics and favors the emergence of rare infectious diseases: A case report of Hafnia Alvei pneumonia.

Salvatore Lucio Cutuli, Flavio De Maio, Gennaro De Pascale, Domenico Luca Grieco et autres

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