Jin Zeng

SpatialGeo:Boosting Spatial Reasoning in Multimodal LLMs via Geometry-Semantics Fusion

Jiajie Guo, Qingpeng Zhu, Jin Zeng, Xiaolong Wu et autres

Multimodal large language models (MLLMs) have achieved significant progress in image and language tasks due to the strong reasoning capability of large language models (LLMs). Nevertheless, most MLLMs suffer from limited spatial reasoning ability to interpret and infer spatial arrangements in three-dimensional …

A novel 450 nm blue laser-mediated sinoporphyrin sodium-based photodynamic therapy inactivates Cutibacterium acnes through stress-mediated metabolic alterations

Hengtong Fan, Zejun Ren, Shuqi Chen, Tingting Huang et autres

cn (code pays fourni par la source)

Psychometric validation of the SNAP-IV rating scale in amblyopic children at high AD/HD risk: structural validity and measurement invariance

Pan Lu, Meng Ru, Yuxing Huang, Lili Li et autres

Objective To validate the psychometric properties of the Swanson, Nolan, and Pelham Rating Scale (SNAP-IV) in amblyopic children at high AD/HD risk and establish its clinical utility for comorbid AD/HD screening. Methods This cross-sectional study utilized baseline data from the China Amblyopia …

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Concurrent Ferroptosis and Pyroptosis Induced by a Dual‐Organelle‐Targeted Type I/II AIE Photosensitizer for Bladder Cancer Immunotherapy

Yifan Cheng, Kun Zhou, Yuhang Chen, Yibo Mei et autres

The therapeutic efficacy and cell death modalities of photodynamic therapy (PDT) highly depend on reactive oxygen species (ROS) generation mediated by photosensitizers (PSs) and their subcellular localization. However, research exploring the potential mechanisms underlying ROS-induced ferroptosis and pyroptosis remains scarce. In this …

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Lactate Activates the HCAR1/β‐Arrestin2/PP2A Signaling Axis to Mediate STAT1/2 Dephosphorylation and Drive Osteosarcoma Progression

Zhitao Han, Qi Jia, Guangjian Bai, Li Zhao et autres

The "Warburg effect", a hallmark of Osteosarcoma(OS), results in lactate accumulation due to aerobic glycolysis. The role and underlying mechanisms of lactate in OS are not well understood. Herein, the lactate-activated hydroxycarboxylate receptor 1(HCAR1) is found to promote OS progression via inhibiting …

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CMPhysBench: A Benchmark for Evaluating Large Language Models in Condensed Matter Physics

W. Wang, Dongchen Huang, Jiatong Li, Ziyang Zheng et autres

We introduce CMPhysBench, designed to assess the proficiency of Large Language Models (LLMs) in Condensed Matter Physics, as a novel Benchmark. CMPhysBench is composed of more than 520 graduate-level meticulously curated questions covering both representative subfields and foundational theoretical frameworks of condensed …

Combined oxybenzone and UVB exposure induces metabolic and neural dysregulation in Mugilogobius chulae embryos and larvae

Yimeng Wang, Jinzhi Ren, Yufei Zhao, Xiangping Nie et autres

The widespread use of sunscreens has contaminated aquatic environments with UV filters like oxybenzone (BP-3), which act as endocrine disruptors in aquatic organisms and exhibit enhanced toxicity under UV radiation. This study employed a multi-omics approach integrating responses from genes to whole …

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Development of a prognostic model for osteosarcoma based on macrophage polarization-related genes using machine learning: implications for personalized therapy

Jin Zeng, Dong Wang, ZhaoChen Tong, Zixin Li et autres

While neoadjuvant chemotherapy combined with surgical resection has improved the prognosis for patients with osteosarcoma, its impact on metastatic and recurrent cases remains limited. Immunotherapy is emerging as a promising alternative. However, the relationship between the phenotype of tumor-associated macrophages and the …

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Biopolymer-based bone scaffold for controlled Pt (IV) prodrug release and synergistic photothermal-chemotherapy and immunotherapy in osteosarcoma

Zuyun Yan, Youwen Deng, Liping Huang, Jin Zeng et autres

Achieving bone defect repair while preventing tumor recurrence after osteosarcoma surgery has consistently posed a clinical challenge. Local treatment with 3D-printed scaffolds loaded with chemotherapeutic drugs can exert certain effects in tumor inhibition and bone regeneration. However, the non-specific activation of chemotherapeutic …

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Enhanced Immune Modulation and Bone Tissue Regeneration through an Intelligent Magnetic Scaffold Targeting Macrophage Mitochondria

Zuyun Yan, Tianshi Sun, Jin Zeng, Tao He et autres

During the bone tissue repair process, the highly dynamic interactions between the host and materials hinder precise, stable, and sustained immune modulation. Regulating the immune response based on potential mechanisms of macrophage phenotypic changes may represent an effective strategy for promoting bone …

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Business cycle asynchrony in European countries: a nonlinear panel data analysis

Ruoxun Ma, Jin Zeng

This study employs a Nonlinear Asynchronous Multilevel Smooth Transition Panel (NAML-STP) model to investigate the asynchrony of economic cycles among European Union countries. Utilizing GDP data from 27 EU nations, the research reveals significant nonlinear characteristics and sequential differences in the timing …

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Retraction Notice: Optimized Turmeric Extract Reduces β-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer's Transgenic Mice

R. Douglas Shytle, Jun Tan, Paula C. Bickford, Kavon Rezai‐Zadeh et autres

This article titled "Optimized Turmeric Extract Reduces β-Amyloid and Phosphorylated Tau Protein Burden in Alzheimer's Transgenic Mice," published in Volume 9, Issue 4, 2012 of Current Alzheimer Research (10.2174/156720512800492459 ) has been retracted by the publisher following a thorough investigation that revealed …

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