Yibo Mei

Hexylaminolevulinic acid in precision medicine: A review of advances in drug delivery and combination therapeutics

Lijiang Gu, Pan Zhang, Yibo Mei, Zheng Wang et autres

• Hexylaminolevulinic acid (HAL) causes the accumulation of protoporphyrin IX (PpIX) in tumor cells within a hormonal microenvironment by upregulating coproporphyrinogen oxidase (CPOX) and protoporphyrinogen oxidase (PPOX) and inhibiting ferrochelatase (FECH). • HAL's superior lipophilicity and cellular uptake over ALA, leads to …

cn (code pays fourni par la source)

A novel 450 nm blue laser-mediated sinoporphyrin sodium-based photodynamic therapy inactivates Cutibacterium acnes through stress-mediated metabolic alterations

Hengtong Fan, Zejun Ren, Shuqi Chen, Tingting Huang et autres

cn (code pays fourni par la source)

Concurrent Ferroptosis and Pyroptosis Induced by a Dual‐Organelle‐Targeted Type I/II AIE Photosensitizer for Bladder Cancer Immunotherapy

Yifan Cheng, Kun Zhou, Yuhang Chen, Yibo Mei et autres

The therapeutic efficacy and cell death modalities of photodynamic therapy (PDT) highly depend on reactive oxygen species (ROS) generation mediated by photosensitizers (PSs) and their subcellular localization. However, research exploring the potential mechanisms underlying ROS-induced ferroptosis and pyroptosis remains scarce. In this …

cn (code pays fourni par la source)

Concurrent Ferroptosis and Pyroptosis Induced by a Dual‐Organelle‐Targeted Type I/II AIE Photosensitizer for Bladder Cancer Immunotherapy

Yifan Cheng, Kun Zhou, Yuhang Chen, Yibo Mei et autres

Abstract The therapeutic efficacy and cell death modalities of photodynamic therapy (PDT) highly depend on reactive oxygen species (ROS) generation mediated by photosensitizers (PSs) and their subcellular localization. However, research exploring the potential mechanisms underlying ROS‐induced ferroptosis and pyroptosis remains scarce. In …

cn (code pays fourni par la source)

The photothermal effect induces M1 macrophage-derived TNF-α-type exosomes to inhibit bladder tumor growth

Minxuan Jing, Minghai Ma, Mengzhao Zhang, Yibo Mei et autres

cn (code pays fourni par la source)

A Novel Photosensitizer Based 450-nm Blue Laser-Mediated Photodynamic Therapy Induces Apoptosis in Colorectal Cancer – in Vitro and in Vivo Study

Yibo Mei, Lijiang Gu, Yuhang Chen, Pan Zhang et autres

Background: Due to its non-invasive and widely applicable features, photodynamic therapy (PDT) has been a prominent treatment approach against cancer in recent years. However, its widespread application in clinical practice is limited by the dark toxicity of photosensitizers and insufficient penetration of …

cn (code pays fourni par la source)

Gut Microbiota Disorders in Obesity-Associated Benign Prostatic Hyperplasia in Rats

Lijiang Gu, Akehu Alemasi, Yuhang Chen, Xing Li et autres

cn (code pays fourni par la source)

Elucidating the role of RBM5 in osteoclastogenesis: a novel potential therapeutic target for osteoporosis

Yuyang Zhang, Xue Chen, Yuan Xiao, Yibo Mei et autres

Osteoporosis is a prevalent bone disease with multigene involved, and the molecular mechanisms of its pathogenesis are not entirely understood. This study aims to identify novel key genes involved in osteoporosis to discover potential pharmacological targets. We analyzed three microarray datasets and …

cn (code pays fourni par la source)

A novel PDT: 5-aminolevulinic acid combined 450 nm blue laser photodynamic therapy significantly promotes cell death of HR-HPV infected cells

Yuqing Chen, Yibo Mei, Lijiang Gu, Xing Li et autres

Human papillomavirus (HPV) infection and related diseases are clinical challenges. The efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) using red laser (630 ± 5 nm) is remarkable and safe. In this study, we aim to investigate the efficacy of ALA-450 nm PDT …

cn (code pays fourni par la source)

Additional file 1 of A novel 450-nm laser-mediated sinoporphyrin sodium-based photodynamic therapy induces autophagic cell death in gastric cancer through regulation of the ROS/PI3K/Akt/mTOR signaling pathway

Xing Li, Lijiang Gu, Yuhang Chen, Xiaobing Wang et autres

Additional file 1: Fig. S1. Cellular uptake of DVDMS and cytotoxic effects of PDT in GC cells. (A and B) Representative fluorescence images and quantitative analysis of the intracellular uptake of DVDMS after different incubation time points. Scale bar = 10 μm. …

cn, us, au (code pays fourni par la source)

Additional file 1 of Elucidating the role of RBM5 in osteoclastogenesis: a novel potential therapeutic target for osteoporosis

Yuyang Zhang, Xue Chen, Yuan Xiao, Yibo Mei et autres

Additional file 1: Table S1. The primers used for RT-qPCR analysis.

cn (code pays fourni par la source)

A novel 450-nm laser-mediated sinoporphyrin sodium-based photodynamic therapy induces autophagic cell death in gastric cancer through regulation of the ROS/PI3K/Akt/mTOR signaling pathway

Xing Li, Lijiang Gu, Yuhang Chen, Xiaobing Wang et autres

BACKGROUND: Photodynamic therapy (PDT) has become an ideal and promising therapeutic method for fighting cancer, but its common application in clinical practice is prevented by the limitations of expensive devices in light sources and phototoxicity in photosensitizers. The aim of this study …

cn, tw (code pays fourni par la source)