Lidia Boasiako

Unexpectedly competent immune response to SARS-CoV-2 vaccination in Rett syndrome

Ludovica Soldateschi, Silvia Leoncini, Fabio Fiorino, Simone Lucchesi et autres

Rett syndrome (RTT) is a rare neurodevelopmental disorder of genetic origin characterized by chronic low-grade inflammation, immune imbalance, and frequently associated with compromised respiratory function. During the COVID-19 pandemic, individuals with RTT were classified as high-risk and invited to follow stringent vaccination …

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Unexpectedly competent immune response to SARS-CoV-2 vaccination in Rett syndrome

Ludovica Soldateschi, Silvia Leoncini, Fabio Fiorino, Simone Lucchesi et autres

Rett syndrome (RTT) is a rare neurodevelopmental disorder of genetic origin characterized by chronic low-grade inflammation, immune imbalance, and frequently associated with compromised respiratory function. During the COVID-19 pandemic, individuals with RTT were classified as high-risk and invited to follow stringent vaccination …

Unexpectedly competent immune response to SARS-CoV-2 vaccination in Rett syndrome

Ludovica Soldateschi, Silvia Leoncini, Fabio Fiorino, Simone Lucchesi et autres

Rett syndrome (RTT) is a rare neurodevelopmental disorder of genetic origin characterized by chronic low-grade inflammation, immune imbalance, and frequently associated with compromised respiratory function. During the COVID-19 pandemic, individuals with RTT were classified as high-risk and invited to follow stringent vaccination …

24-h continuous non-invasive multiparameter home monitoring of vitals in patients with Rett syndrome by an innovative wearable technology: evidence of an overlooked chronic fatigue status

Silvia Leoncini, Lidia Boasiako, Sofia Di Lucia, Amir Beker et autres

Background Sleep is disturbed in Rett syndrome (RTT), a rare and progressive neurodevelopmental disorder primarily affecting female patients (prevalence 7.1/100,000 female patients) linked to pathogenic variations in the X-linked methyl-CpG-binding protein 2 ( MECP2 ) gene. Autonomic nervous system dysfunction with a …

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Natural Course of IQSEC2-Related Encephalopathy: An Italian National Structured Survey

Silvia Leoncini, Lidia Boasiako, Diego Lopergolo, Maria Altamura et autres

Pathogenic loss-of-function variants in the IQ motif and SEC7 domain containing protein 2 (IQSEC2) gene cause intellectual disability with Rett syndrome (RTT)-like features. The aim of this study was to obtain systematic information on the natural history and extra-central nervous system (CNS) …

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Breathing Abnormalities During Sleep and Wakefulness in Rett Syndrome: Clinical Relevance and Paradoxical Relationship With Circulating Pro-oxidant Markers

Silvia Leoncini, Cinzia Signorini, Lidia Boasiako, Valeria Scandurra et autres

Background Breathing abnormalities are common in Rett syndrome (RTT), a pervasive neurodevelopmental disorder almost exclusively affecting females. RTT is linked to mutations in the methyl-CpG-binding protein 2 (MeCP2) gene. Our aim was to assess the clinical relevance of apneas during sleep-wakefulness cycle …

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