24-h continuous non-invasive multiparameter home monitoring of vitals in patients with Rett syndrome by an innovative wearable technology: evidence of an overlooked chronic fatigue status
Rattachement africain : it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Sleep is disturbed in Rett syndrome (RTT), a rare and progressive neurodevelopmental disorder primarily affecting female patients (prevalence 7.1/100,000 female patients) linked to pathogenic variations in the X-linked methyl-CpG-binding protein 2 ( MECP2 ) gene. Autonomic nervous system dysfunction with a predominance of the sympathetic nervous system (SNS) over the parasympathetic nervous system (PSNS) is reported in RTT, along with exercise fatigue and increased sudden death risk. The aim of the present study was to test the feasibility of a continuous 24 h non-invasive home monitoring of the biological vitals (biovitals) by an innovative wearable sensor device in pediatric and adolescent/adult RTT patients. Methods A total of 10 female patients (mean age 18.3 ± 9.4 years, range 4.7–35.5 years) with typical RTT and MECP2 pathogenic variations were enrolled. Clinical severity was assessed by validated scales. Heart rate (HR), respiratory rate (RR), and skin temperature (SkT) were monitored by the YouCare Wearable Medical Device (Accyourate Group SpA, L’Aquila, Italy). The average percentage of maximum HR (HRmax%) was calculated. Heart rate variability (HRV) was expressed by consolidated time-domain and frequency-domain parameters. The HR/LF (low frequency) ratio, indicating SNS activation under dynamic exercise, was calculated. Simultaneous continuous measurement of indoor air quality variables was performed and the patients’ contributions to the surrounding water vapor partial pressure [P H2O (pt)] and carbon dioxide [P CO2 (pt)] were indirectly estimated. Results Of the 6,559.79 h of biovital recordings, 5051.03 h (77%) were valid for data interpretation. Sleep and wake hours were 9.0 ± 1.1 h and 14.9 ± 1.1 h, respectively. HRmax % [median: 71.86% (interquartile range 61.03–82%)] and HR/LF [median: 3.75 (interquartile range 3.19–5.05)] were elevated, independent from the wake–sleep cycle. The majority of HRV time- and frequency-domain parameters were significantly higher in the pediatric patients ( p ≤ 0.031). The HRV HR/LF ratio was associated with phenotype severity, disease progression, clinical sleep disorder, subclinical hypoxia, and electroencephalographic observations of multifocal epileptic activity and general background slowing. Conclusion Our findings indicate the feasibility of a continuous 24-h non-invasive home monitoring of biovital parameters in RTT. Moreover, for the first time, HRmax% and the HR/LF ratio were identified as potential objective markers of fatigue, illness severity, and disease progression.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- 24-h continuous non-invasive multiparameter home monitoring of vitals in patients with Rett syndrome by an innovative wearable technology: evidence of an overlooked chronic fatigue status
- Date Crossref
- 17/06/2024
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Azienda Ospedaliera Universitaria Senese Neonatal Intensive Care Unit pays non établi dans la noticeÉtablissement de santé
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Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda pays non établi dans la noticeÉtablissement de santé
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Ospedale San Paolo pays non établi dans la noticeÉtablissement de santé
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Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo pays non établi dans la noticeOrganisme public
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Istituto Giannina Gaslini pays non établi dans la noticeÉtablissement de santé
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University of Genoa pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliera Universitaria Policlinico "G. Martino" pays non établi dans la noticeÉtablissement de santé
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University of Messina Department of Biomedical and Dental Sciences and of Morphological and Functional Imaging (BIOMORF) pays non établi dans la noticeUniversité ou école supérieure
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Bambino Gesù Children's Hospital Academic Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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University of Siena Department of Molecular and Developmental Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of Trieste Department of Life Sciences pays non établi dans la noticeUniversité ou école supérieure
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Associazione della Croce Rossa Italiana pays non établi dans la noticeInstitution
Neonatal Intensive Care Unit — Azienda Ospedaliera Universitaria Senese, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda et Ospedale San Paolo, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.