Ai Kotani

EBV promotes alveolar trabecula resorption via extracellular vesicle remodeling by group IIA secreted phospholipase A2

Akane Kanamori, Akira Hasuike, Kai Kudo, Joaquim Sempere Carreras et autres

Epstein–Barr virus (EBV) is an enveloped, double-stranded DNA virus that selectively infects primates. Periodontitis, a common inflammatory disease characterized by alveolar bone destruction, affects over half of the global adult population. While EBV has been linked to periodontitis due to its pro-inflammatory …

jp (code pays fourni par la source)

Author response: A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

Yuji Miyatake, Takeshi Kamakura, Tomokatsu Ikawa, Ryo Yanagiya et autres

jp (code pays fourni par la source)

A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

Yuji Miyatake, Takeshi Kamakura, Tomokatsu Ikawa, Ryo Yanagiya et autres

Accumulated studies have reported that hematopoietic differentiation was primarily regulated by transcription factors. Early B cell factor 1 (EBF1) is an essential transcription factor for B lymphopoiesis. Contrary to the canonical notion, we found that a single miRNA, miRNA-195 ( Mir195 ) …

jp, in, de (code pays fourni par la source)

A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

Yuji Miyatake, Tsutomu Ikawa, Tomokatsu Ikawa, Ryo Yanagiya et autres

Accumulated studies have reported that hematopoietic differentiation was primarily regulated by transcription factors. Early B cell factor 1 (EBF1) is an essential transcription factor for B lymphopoiesis. Contrary to the canonical notion, we found that a single miRNA, miRNA-195 (miR-195) transduction let …

jp, in, de (code pays fourni par la source)

Author response: A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

Yuji Miyatake, Takeshi Kamakura, Tomokatsu Ikawa, Ryo Yanagiya et autres

Accumulated studies have reported that hematopoietic differentiation was primarily regulated by transcription factors. Early B cell factor 1 (EBF1) is an essential transcription factor for B lymphopoiesis. Contrary to the canonical notion, we found that a single miRNA, miRNA-195 (miR-195) transduction let …

Reviewer #1 (Public review): A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

Yuji Miyatake, Takeshi Kamakura, Tomokatsu Ikawa, Ryo Yanagiya et autres

Accumulated studies have reported that hematopoietic differentiation was primarily regulated by transcription factors. Early B cell factor 1 (EBF1) is an essential transcription factor for B lymphopoiesis. Contrary to the canonical notion, we found that a single miRNA, miRNA-195 (miR-195) transduction let …

Reviewer #3 (Public review): A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

Yuji Miyatake, Takeshi Kamakura, Tomokatsu Ikawa, Ryo Yanagiya et autres

Accumulated studies have reported that hematopoietic differentiation was primarily regulated by transcription factors. Early B cell factor 1 (EBF1) is an essential transcription factor for B lymphopoiesis. Contrary to the canonical notion, we found that a single miRNA, miRNA-195 (miR-195) transduction let …

Reviewer #2 (Public review): A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

Yuji Miyatake, Takeshi Kamakura, Tomokatsu Ikawa, Ryo Yanagiya et autres

Accumulated studies have reported that hematopoietic differentiation was primarily regulated by transcription factors. Early B cell factor 1 (EBF1) is an essential transcription factor for B lymphopoiesis. Contrary to the canonical notion, we found that a single miRNA, miRNA-195 (miR-195) transduction let …

Successful Treatment of Chronic Active Epstein-Barr Virus Infection Complicated by Cardiomyopathy in an Adult Patient

Kaito Harada, Shino Iwata, Shinichiro Machida, Daisuke Furuya et autres

Chronic active Epstein-Barr virus infection (CAEBV) is a rare and potentially fatal condition involving EBV-infected T or natural killer cells. We herein report a 46-year-old man with CAEBV complicated by cardiomyopathy. Imaging and a biopsy revealed EBV-positive CD3+ T cell infiltration in …

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Revised model for cell cycle regulation by iron: differential roles between transferrin and ferritin

Ryo Yanagiya, Hiroko Kato, Akinori Ninomiya, Masaya Ueno et autres

Iron is essential for neoplasms including natural killer (NK) cell lymphoma, and mainly supplemented by transferrin and stored by ferritin. Although accumulating studies had demonstrated that iron chelation arrests cell cycle progression at G1 phase, our previous studies showed the induction of …

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Aberrant expression of human endogenous retrovirus K9-derived elements is associated with better clinical outcome of acute myelocytic leukemia

Ryo Yanagiya, So Nakagawa, Makoto Onizuka, Ai Kotani

BACKGROUND: Acute myelocytic leukemia (AML) is a common hematological malignancy in adults. Although several risk stratifications based on cytogenetic and molecular abnormalities are available to guide the indications for allogeneic hematopoietic cell transplantation (allo-HCT), determining optimal treatment strategies for AML remains challenging. …

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[New mechanisms and therapeutic targets for viral tumors].

Ai Kotani

Virus-related cancers remain a notable subset of all cancers, and many are still difficult to control, despite the fact that most infectious diseases other than emerging infectious ones can now be controlled. Among these, Epstein-Barr virus (EBV)-associated cancers, which are less common …

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