Ullas Mony

Outcomes of Chimeric Antigen Receptor T-cell (CAR-T) Cell Therapy in Hematological Malignancies - A Systematic Review and Meta Analysis

Ullas Mony, Vishnu Priya Veeraraghavan, Neeraj Sidharthan

INTRODUCTION: CAR T therapy is used in various hematological malignancies that involve genetic modification of autologous T cells to target tumor cells. The aim of this meta-analysis was to evaluate the efficacy and safety of CAR T cell therapy in haematological malignancies …

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Role of Immunological Markers in Diagnosis, Prognosis, and Treatment of Early Childhood Caries and Adult Caries: A Systematic Review

Vishnu Priya Veeraraghavan, Ullas Mony, Gamal Othman, Bashayer Khalid Alskait

Background: Dental caries is a common oral health problem that affects people all over the world. To detect and treat it early on, it is important to have a thorough understanding of its genesis and potential biomarkers. Objective: The objective of this …

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Lower dose emicizumab prophylaxis in children with hemophilia A: Real - world outcomes, hemostatic profiles and cost- effectiveness from a resource limited setting

Lincy Paul, Niranjan Vijayakumar, Anandakrishnan Nandakumar, Georg Gutjahr et autres

Abstract Background: Although Emicizumab has transformed prophylaxis in Hemophilia A management, standard-dose therapy remains inaccessible for most in resource-limited settings. Evidence on lower dose Emicizumab in real-world pediatric cohorts is limited. Objective: To assess clinical outcomes, thromboelastography (TEG) profiles, and cost-effectiveness in …

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Early post-infusion cytokine profiling predicts toxicity and outcomes in recipients of NexCAR19 (Actalycabtagene Autoleucel): A pilot study with point-of-care assay integration

Gopal Nandkishor Sinhal, Monisha Harimadhavan, Gayathri Sajeevan, Anandakrishnan Nandakumar et autres

Abstract Background: CD19-directed CAR-T cell therapies have significantly improved outcomes in relapsed/refractory (R/R) B-cell malignancies, including acute lymphoblastic leukemia (B-ALL) and non-Hodgkin lymphoma (B-NHL). Despite their efficacy, these therapies are associated with serious early toxicities, particularly cytokine release syndrome (CRS) and immune …

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Immune system modifications in atypical parkinsonism related to autoimmunity - a case control study

Annamma Mathai, Sudheeran Kannoth, Vivek Nambiar, Siby Gopinath et autres

Background Inflammation is known in atypical parkinsonism (AP), but the role of autoimmunity is unclear. This study evaluates immune system modifications suggesting autoimmunity in AP.Methods Included patients with AP diagnosed at Amrita Institute of Medical Sciences, Kochi (December 2018–May 2019), and age- …

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Outcomes of tumor-infiltrating lymphocyte therapy in solid tumours – A systematic review and meta analysis

Ullas Mony, Vishnu Priya Veeraraghavan

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Targeting protein kinase D in oral squamous cell carcinoma: a promising therapeutic approach

Vishnu Priya Veeraraghavan, Krishna Mohan Surapaneni, Lavina Prashar, Ullas Mony

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Clinical Characteristics and Outcomes of Patients with Paroxysmal Nocturnal Hemoglobinuria: A Retrospective Study from a Tertiary Care Centre in South India

Gohul Gopi Jalajakumari, Manoj Unni, Vidya Jha, Bindhu Paul‐Prasanth et autres

Introduction Paroxysmal Nocturnal Hemoglobinuria (PNH) is a chronic acquired disorder that can cause hemolysis, thrombosis and aplastic marrow , with an incidence of 1-10 cases per million people. Studies focusing on PNH in the Indian population are relatively sparse. Although C5 inhibitors …

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Establishing a CAR-T Cell Therapy Centre in a Resource Limited Setting: Barriers and Early Outcomes

Shreya Gopal Agrawal, Gopal Nandkishor Sinhal, Manoj Unni, Monisha Harimadhavan et autres

Background: CAR-T cell therapy, while revolutionary for treating relapsed or refractory hematologic malignancies, faces economic and logistical hurdles in low and middle-income countries (LMIC) such as India (per-capita income of $2,100 compared to US $81,000). With treatment costs ranging from $300,000 to …

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Challenges in the Diagnosis and Treatment of AL Amyloidosis in a Resource-Limited Setting: A Retrospective Analysis of Clinical Characteristics and Outcomes at a Newly Established Amyloid Centre in India

Sandeep Abhijit Pattnaik, Hisham Ahamed, Georg Gutjahr, M Akhila et autres

Background: AL (light-chain) amyloidosis, the common form of the complex spectrum of amyloidosis, poses significant diagnostic and therapeutic challenges even in well-resourced healthcare settings owing to non-specific symptoms, delayed diagnosis, limited therapeutic options and the need for specialised diagnostic techniques. In resource-limited …

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Comparison of Improvement in Hemophilia Care in Children over a Decade and Outcomes - a Retrospective Study from Southern Part of India

Lincy Paul, Vijayakumar Narayana Pillai, Rema Ganapathy, Georg Gutjahr et autres

Background: Hemophilia, an X-linked recessive bleeding disorder, presents significant challenges in management but can be mitigated with appropriate clotting factor replacement therapy. Resource limited settings across the world face unique challenges in implementing prophylaxis as the standard of care. The objective of …

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Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation

Nitesh Buldak, Vishnu Priya Veeraraghavan, Ullas Mony

Oral squamous cell carcinoma (OSCC) is a highly aggressive neoplasm of the surface epithelium that arises from the mucosal lining of the mouth. The poor prognosis can be attributed to the complex tumor microenvironment (TME) in OSCC, which is crucial for tumor …

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