Manoj Unni

Early Recovery of Cardiac Function After Hematologic Response in Systemic AL Amyloidosis

Aparna Hari, Neeraj Sidharthan, Manoj Unni, Hisham Ahamed

Cardiac involvement determines prognosis in systemic AL amyloidosis, and functional cardiac recovery typically lags hematologic response by months to years.

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Advancing Hematopoietic Stem Cell Research: The Impact of Bioengineered 3D Bone Marrow Niches

Hridhya K. Sidharthan, Mansi Goel, Manoj Unni, Neeraj Sidharthan et autres

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Real-world outcomes of standard and modified daratumumab-based therapy in AL amyloidosis: A cohort study from a multidisciplinary program in south India

Neeraj Sidharthan, Vivek Ananda Chood O M, Anandakrishnan Nandakumar, Georg Gutjahr et autres

Abstract Background: Systemic light chain (AL) Amyloidosis is a rare plasma cell dyscrasia with an estimated global incidence of 10–15 cases per million annually. The true burden is likely underrecognized in low- and middle-income countries (LMICs), where diagnostic delays are common due …

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Early post-infusion cytokine profiling predicts toxicity and outcomes in recipients of NexCAR19 (Actalycabtagene Autoleucel): A pilot study with point-of-care assay integration

Gopal Nandkishor Sinhal, Monisha Harimadhavan, Gayathri Sajeevan, Anandakrishnan Nandakumar et autres

Abstract Background: CD19-directed CAR-T cell therapies have significantly improved outcomes in relapsed/refractory (R/R) B-cell malignancies, including acute lymphoblastic leukemia (B-ALL) and non-Hodgkin lymphoma (B-NHL). Despite their efficacy, these therapies are associated with serious early toxicities, particularly cytokine release syndrome (CRS) and immune …

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Estimating Normal Reference Interval for Soluble B-Cell Maturation Antigen Levels in Adults: A Prospective Study from a Tertiary Care Center in Southern India

G S Reshmy, Sajitha Krishnan, Manoj Unni, Georg Gutjahr et autres

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A Rare Case of Chronic Ataxic Neuropathy in an Elderly Patient

Suchitra Sivadas, Vivek Kumar Ambastha, U. Gopikrishnan, Manoj Unni et autres

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Clinical Characteristics and Outcomes of Patients with Paroxysmal Nocturnal Hemoglobinuria: A Retrospective Study from a Tertiary Care Centre in South India

Gohul Gopi Jalajakumari, Manoj Unni, Vidya Jha, Bindhu Paul‐Prasanth et autres

Introduction Paroxysmal Nocturnal Hemoglobinuria (PNH) is a chronic acquired disorder that can cause hemolysis, thrombosis and aplastic marrow , with an incidence of 1-10 cases per million people. Studies focusing on PNH in the Indian population are relatively sparse. Although C5 inhibitors …

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Establishing a CAR-T Cell Therapy Centre in a Resource Limited Setting: Barriers and Early Outcomes

Shreya Gopal Agrawal, Gopal Nandkishor Sinhal, Manoj Unni, Monisha Harimadhavan et autres

Background: CAR-T cell therapy, while revolutionary for treating relapsed or refractory hematologic malignancies, faces economic and logistical hurdles in low and middle-income countries (LMIC) such as India (per-capita income of $2,100 compared to US $81,000). With treatment costs ranging from $300,000 to …

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Author’s reply to Jain et al.

Jeny Jimmy, Vidya Jha, GA Ajeesh, B Aryalakshmi et autres

We convey our sincere thanks to Jain et al.[1] for providing insightful commentary on our study “Clinical utility of 7-probe FISH panel in multiple myeloma in a resource-constrained setting: A retrospective and prospective observational study.”[2] (i) The authors have noted that there …

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Clinical utility of 7-probe FISH panel in multiple myeloma in a resource-constrained setting: A retrospective and prospective observational study

Jeny Jimmy, Vidya Jha, GA Ajeesh, B Aryalakshmi et autres

ABSTRACT Background: A 7-probe fluorescence in situ hybridization (FISH) panel identifying abnormalities such as immunoglobulin heavy chain (IGH) rearrangement, deletion 17p (TP53 – tumor protein 53), hyperdiploidy, and amplification of 1q, t(11;14), t(14;16), and t(4;14) aids in diagnosis and treatment planning for …

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Treatment Challenges in Acute Myeloid Leukemia in Lower-Middle-Income Countries: Navigating Intensity, Affordability, and Infections

Chitresh Yadav, Manoj Unni, Monisha Harimadhavan, Rema Ganapathy et autres

Introduction: Acute Myeloid Leukemia (AML) is a highly aggressive and genetically heterogeneous hematologic malignancy with a potentially fatal outcome if left untreated. The standard treatment, the 7+3 regimen, involving intensive chemotherapy, has been the cornerstone of therapy for decades. However, this approach …

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Hematological Manifestations of Antiphospholipid Antibodies: A Case Series from South India

Monisha Harimadhavan, Manoj Unni, Rema Ganapathy, Suchitra Sivadas et autres

Introduction: Antiphospholipid syndrome (APS) is known for its association with unexplained vascular thrombosis and pregnancy-related complications. However, APS can also present with various hematological abnormalities, including thrombocytopenia, autoimmune hemolytic anemia, Evan's syndrome, and thrombotic microangiopathy. While APS is often considered in patients …

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