Accès ouvert
2025
article
OpenAlex
John Wojcik, Mark G. Qian, Anton I. Rosenbaum, Estelle M. Maes et autres
The 19th Workshop on Recent Issues in Bioanalysis (19th WRIB) took place in New Orleans, LA, USA on April 7-11, 2025. Over 1200 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest …
jp, fr, us, de, Égypte, es, nl, br, ca, ch, cn, gb, it, il
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Accès ouvert
2025
article
OpenAlex
Joseph Tweed, Fern Adams-Dam, Justin Bader, Ying Zhang et autres
BACKGROUND: The Bicycle® toxin conjugate (BTC) zelenectide pevedotin, formerly known as BT8009, is a novel bicyclic peptide targeting the Nectin-4 tumor antigen conjugated to the cytotoxin monomethyl auristatin E (MMAE) via a valine-citrulline cleavable linker. Zelenectide pevedotin is currently being investigated in …
gb, ch
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2023
article
OpenAlex
Joseph Tweed, Fern Adams-Dam, Jane Allanson, Kevin L. Holmes et autres
Background: The Bicycle® toxin conjugate BT5528 is a novel peptide therapeutic conjugated to the cytotoxic agent monomethyl auristatin E (MMAE). A bioanalytical assay was developed to quantify BT5528 and unconjugated MMAE in human plasma. Methodology: BT5528 quantitation used a protein precipitation procedure …
gb
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2022
conference-abstract
OpenAlex
Sophia Gayle, Robert J. Aiello, Jane Bechtold, Patricia Bourassa et autres
Abstract Auristatins such as monomethyl auristatin E (MMAE) are a class of high potency microtubule targeting compounds that have an extremely narrow therapeutic window. Targeting potent auristatins to the tumor is the only feasible method of unlocking the clinical potential of such …
us
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2019
article
OpenAlex
Jason Barricklow, Joseph Tweed, Christopher L. Holliman, Ragu Ramanathan
Aim: Microflow tandem mass spectrometry-based methods have been proposed as options to improve sensitivity and selectivity while improving sample utility and solvent consumption. Here, we evaluate a newly introduced microflow source, OptiFlow™, for quantitative performance. Results/methodology: We performed a comparison of the …
us
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2019
article
OpenAlex
Wei Song, Joseph Tweed, Ravi Visswanathan, James P. Saunders et autres
This work represents the first reporting of a comprehensive bioanalytical GLP methodology detailing the mass spectrometric quantitation of PF-05212384 dosed as a targeted polymeric encapsulated nanoparticle (PF-07034663) to monkeys. Polymeric nanoparticles are a type of drug formulation that enables the sustained release …
us
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2016
article
OpenAlex
Leanne Grafmuller, Cong Wei, Ragu Ramanathan, Frank Barletta et autres
AIM: The application of high-resolution MS to antibody-drug conjugate (ADC) drug development may provide insight into their safety and efficacy. Quantification of unconjugated cytotoxic drug (payload) and characterization of drug-to-antibody ratio distribution were determined in plasma using orthogonal acceleration quadrupole-time-of-flight MS. RESULTS: …
us
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Accès ouvert
2016
article
OpenAlex
Violet Lee, Ang Liu, Elizabeth Groeber, Mehran F. Moghaddam et autres
Boston Society's 11th Annual Applied Pharmaceutical Analysis conference, Hyatt Regency Hotel, Cambridge, MA, USA, 14-16 September 2015 The Boston Society's 11th Annual Applied Pharmaceutical Analysis (APA) conference took place at the Hyatt Regency hotel in Cambridge, MA, on 14-16 September 2015. The …
us
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2013
other
OpenAlex
Joseph Tweed
This chapter provides a comprehensive perspective regarding the use of various robotic liquid handling platforms in automation assisted liquid chromatography-tandem mass spectrometry (LC-MS/MS) bioanalysis, herby referred to LC-MS for the purposes of this abstract. It discusses approaches to creating reliable and robust …
us
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2012
article
OpenAlex
Joseph Tweed, Justin Walton, Zhenhua Gu
BACKGROUND: A new bioanalytical sample preparation approach has been developed to enhance the efficiency, reduce errors and improve the data quality supporting routine toxicokinetic (TK) study samples analysis, via the implementation of 2D barcode processing coupled with fully automated supported liquid extraction …
us
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2010
article
OpenAlex
Joseph Tweed, Zhenhua Gu, Hui Xu, Guodong Zhang et autres
BACKGROUND: A novel approach for regulated bioanalytical sample preparation has been developed to combine multiple types of extraction techniques into one integrated and automated sample-preparation suite that pairs a graphical user interface with the Hamilton Microlab(®) STAR robotic liquid handler. RESULTS: The …
us
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2010
article
OpenAlex
Eugene P. Kadar, Yi Su, Yizhong Zhang, Joseph Tweed et autres
BACKGROUND: The distribution coefficient, D, is a physicochemical property used to determine the partitioning of compounds between aqueous and hydrophobic media at a given pH. RESULTS: A clear relationship was observed between the calculated pH-dependent distribution coefficient of six representative pharmaceutical probe …
us
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