Evaluation of The Relationship Between A Pharmaceutical Compound’s Distribution Coefficient, Log D and Adsorption Loss to Polypropylene in Urine and CSF
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Le résumé fourni par la source
BACKGROUND: The distribution coefficient, D, is a physicochemical property used to determine the partitioning of compounds between aqueous and hydrophobic media at a given pH. RESULTS: A clear relationship was observed between the calculated pH-dependent distribution coefficient of six representative pharmaceutical probe compounds and their propensity to partition between a relatively hydrophobic polypropylene surface and the aqueous matrices, human urine or human cerebrospinal fluid (CSF). Compound log D cut-off values of 1.5 and 3.8 for urine and CSF, respectively, were determined using a threshold of less than 20% adsorption to the polypropylene surface. CONCLUSION: The ability to forecast the adsorption of a given compound to a polypropylene container with urine and CSF offers an effective means for screening potential issues and identifying when additional testing and corrective measures may need to be applied.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Evaluation of The Relationship Between A Pharmaceutical Compound’s Distribution Coefficient, Log D and Adsorption Loss to Polypropylene in Urine and CSF
- Date Crossref
- 01/04/2010
- Éditeur
- Informa UK Limited
- Type
- journal-article
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