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Aliona Wöhler, Arnulf G. Willms, A Scholz, Nina Kühler et autres
Supplementary Material 1.
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Aliona Wöhler, Arnulf G. Willms, A Scholz, Nina Kühler et autres
Supplementary Material 1.
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Aliona Wöhler, Arnulf G. Willms, A Scholz, Nina Kühler et autres
Thoracic trauma is a major contributor to morbidity in severely injured patients and is frequently associated with prolonged mechanical ventilation, tracheostomy, and extended intensive care unit (ICU) treatment. Early identification of patients at risk for unfavorable respiratory-support trajectories remains challenging. Small extracellular …
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Pablo S. Bravo, Xue Qian, Qianying Chen, Christoph Eckert et autres
Remodeling of the pulmonary extracellular matrix (ECM) is a key feature of lung injury and disease. Elastic fibers are a central component of the lung ECM, providing resilience and recoil necessary for normal respiratory function, and their disruption contributes to impaired tissue …
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Cristiana Maria Grapa, Tudor Mocan, Daniel‐Corneliu Leucuta, Rareș Crăciun et autres
Background and Aims: To develop an inclusive, predictive framework for hepatocellular carcinoma patients, beyond what the Barcelona Clinic Liver Cancer (BCLC) staging system captures alone, non-invasive scores have emerged as potential contributors. Among them, the CRAFITY score (CRP and AFP in ImmunoTherapY), …
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Rebekka J. S. Salzmann, Tudor Mocan, Arnulf Gregor Willms, Angelina Klein et autres
Background & Aims Within the Liver Imaging Reporting and Data System (LI-RADS), LI-RADS Malignant (LR-M) lesions remain diagnostically challenging: imaging indicates malignancy but often fails to distinguish hepatocellular carcinoma (HCC) from intrahepatic cholangiocarcinoma (iCCA). Established serum-based tools such as GALAD are optimized …
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Arnulf Gregor Willms, Aliona Wöhler, Robert Schwab, Sebastian Schaaf et autres
The exploration of biomarkers in trauma and critical care is an evolving field, with cellular, molecular, and vesicular pathways offering insights into immune dysregulation after injury. In recent years, liquid biopsy-based approaches have emerged as promising tools, exemplified by initiatives such as …
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Arnulf Gregor Willms, Marcin Krawczyk, Henrike Julich‐Haertel, Sabine K. Gries et autres
Background & Aims: tumor-associated microparticles. Despite promising biology, the diagnostic utility was limited by the analytical tools available at the time, resulting in modest performance (AUC 0.70, 75% sensitivity, 47% specificity). Methods: In the present study, we revisited this legacy dataset - …
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Aliona Wöhler, Bingduo Wang, Robert Schwab, Veronika Lukacs‐Kornek et autres
Abstract Liquid biomarkers are essential in trauma cases and critical care and offer valuable insights into the extent of injury, prognostic predictions, and treatment guidance. They can help assess the severity of organ damage (OD), assist in treatment decisions and forecast patient …
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Miroslaw Kornek, Tim Hendrikx, Salvatore Sutti
Non-alcoholic fatty liver disease (NAFLD) was recently renamed to metabolic dysfunctionassociated liver disease (MASLD) to emphasize the metabolic dysfunctions that most often accompany its manifestation [1]. MASLD covers a spectrum of liver diseases, ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), …
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Aliona Wöhler, Sabine K. Gries, Rebekka J. S. Salzmann, Christina Krötz et autres
Abstract Despite significant progress in the medical field, there is still a pressing need for minimal‐invasive tools to assist with decision‐making, especially in cases of polytrauma. Our team explored the potential of serum‐derived large extracellular vesicles, so called microparticles/microvesicles/ectosomes, to serve as …
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Aliona Wöhler, Miroslaw Kornek, Biao Wang, Veronika Lukacs‐Kornek et autres
Einführung: Die Milz gehört zu dem am häufigsten verletzten parenchymatösen Organ im Rahmen von Polytrauma. Kürzlich haben wir nachgewiesen, dass eine spezifische Untergruppe kleiner extrazellulärer Vesikel (sEVs) einen neuen diagnostischen Ansatz in der Beurteilung des Schweregrades eines Milztraumas mit potenziellem klinischem Nutzen …
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