Anett Peters

Granzyme K-Expressing CD8+ T Cells Drive Complement Activation and Tissue Damage in ANCA-Associated Glomerulonephritis

Ulf Panzer, Nariaki Asada, Huiying Wang, Zeba Sultana et autres

Background: ANCA–associated vasculitis is a systemic autoimmune disease and the most common cause of rapidly progressive GN (ANCA-GN). Recent experimental and clinical studies highlight the critical role of the complement system in the pathogenesis of ANCA-GN, but the underlying molecular mechanisms driving …

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Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease

Zeba Sultana, Robin Khatri, Behnam Yousefi, Nikhat Shaikh et autres

Rapidly progressive glomerulonephritis (RPGN) is the most aggressive group of autoimmune kidney diseases and is characterized by glomerular crescent formation with proliferation of parietal epithelial cells (PECs). However, the underlying mechanisms of glomerular crescent formation are incompletely understood. Here we provide a …

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Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice

Jonas Engeßer, Robin Khatri, Darius P. Schaub, Hans‐Joachim Paust et autres

In anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and systemic lupus erythematosus (SLE), glomerulonephritis is a severe kidney complication driven by immune cells, including T cells. However, the mechanisms underlying T cell activation in these contexts remain elusive. Here we report that in patients …

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The integrated stress response pathway controls cytokine production in tissue-resident memory CD4+ T cells

Nariaki Asada, Pauline Ginsberg, Hans‐Joachim Paust, Ning Song et autres

Abstract Tissue-resident memory T (T RM ) cells are a specialized T cell population that reside in tissues and provide a rapid protective response upon activation. Here, we showed that human and mouse CD4 + T RM cells existed in a poised …

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Spatio-temporal interaction of immune and renal cells determines glomerular crescent formation in autoimmune kidney disease

Zeba Sultana, Robin Khatri, Behnam Yousefi, Nikhat Shaikh et autres

Abstract Rapidly progressive glomerulonephritis (RPGN) is the most aggressive group of autoimmune kidney disease with the worst prognosis. Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis, anti-glomerular basement membrane (anti-GBM) and lupus nephritis are the most common causes of RPGN and are characterized by …

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S1PR1 mediates Th17 cell migration from the thymus to the skin in health and disease

Jonas Engeßer, Huiying Wang, Sonja Kapffer, Anna Kaffke et autres

Th17 cells play crucial roles in host defense and the pathogenesis of autoimmune diseases in the skin. While their differentiation mechanisms have been extensively studied, the origin of skin Th17 cells remains unclear. In this study, we analyzed single-cell RNA-sequencing data and …

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Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis

Jonas Engeßer, Robin Khatri, Darius P. Schaub, Yu Zhao et autres

Abstract Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a life-threatening autoimmune disease that often results in kidney failure caused by crescentic glomerulonephritis (GN). To date, treatment of most patients with ANCA-GN relies on non-specific immunosuppressive agents, which may have serious adverse effects and …

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Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis

Jonas Engeßer, Robin Khatri, Darius P. Schaub, Yu Zhao et autres

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The integrated stress response/eIF2a pathway controls cytokine production in tissue-resident memory CD4 + T cells

Nariaki Asada, Pauline Ginsberg, Hans‐Joachim Paust, Ning Song et autres

SUMMARY Tissue-resident memory T (Trm) cells are a specialized T cell population that resides in tissues and can play both a protective and pathogenic role. The mechanism that enables Trm cells to provide a rapid protective response while restricting their function in …

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Targeting Monocyte Derived CCL17 Attenuates Murine Crescentic Glomerulonephritis by Affecting Renal CCR4+ Regulatory T-Cell Recruitment

Ning Song, Hans‐Joachim Paust, Nariaki Asada, Anett Peters et autres

INTRODUCTION: The chemokine receptor CCR4 is expressed by diverse CD4+ T cell subsets including regulatory T cells (Tregs) but its functional importance for leukocyte recruitment and the relevance of its two corresponding chemokines CCL17 and CCL22 have not been studied in immune-mediated …

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CD4 + T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12

Hans‐Joachim Paust, Ning Song, Donatella De Feo, Nariaki Asada et autres

GM-CSF in glomerulonephritis Despite glomerulonephritis being an immune-mediated disease, the contributions of individual immune cell types are not clear. To address this gap in knowledge, Paust et al . characterized pathological immune cells in samples from patients with glomerulonephritis and in samples …

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Glucocorticoids target the CXCL9/CXCL10-CXCR3 axis and confer protection against immune-mediated kidney injury

Jan-Hendrik Riedel, Lennart Robben, Hans‐Joachim Paust, Yu Zhao et autres

Glucocorticoids remain a cornerstone of therapeutic regimes for autoimmune and chronic inflammatory diseases - for example, in different forms of crescentic glomerulonephritis - because of their rapid antiinflammatory effects, low cost, and wide availability. Despite their routine use for decades, the underlying …

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