Marianne Léger

AUT00206, a novel and selective Kv3.1/3.2 channel modulator, restores cognitive dysfunction and negative symptoms in an animal model for schizophrenia symptomatology

Marianne Léger, Daniela Cadinu, Jennifer Fletcher, Agostino Marasco et autres

BACKGROUND: Voltage-gated Kv3.1 and KV3.2 potassium channels are mainly located on parvalbumin (PV) containing interneurons, where they play a key role in synchronising the coordinated firing of pyramidal neurons and regulating cognitive function. AIMS: We aim to explore the efficacy of acute …

fr, gb, it (code pays fourni par la source)

Proteomic signatures of cognitive resilience in LOU/c/Jall rats converge with inverse hippocampal axes of Alzheimer’s disease

Lucas Gephine, Aurélien BADINA, Sophie Corvaisier, Benjamin B. Tournier et autres

ABSTRACT Why some individuals maintain good level of cognitive performances during aging, others don’t or even progress toward Alzheimer’s disease. We profiled the hippocampal proteome of adult LOU/c/Jall rats, a strain associated with spontaneous cognitive longevity, and compared this proteomic state with …

fr, ch (code pays fourni par la source)

Synergistic effect of 5-HT4 receptor activation and phosphodiesterase type 7 inhibition on object recognition and working memory performances in adult mice

Dahyanna-Camille Le Ridant, Thomas Fréret, Michel Boulouard, Marianne Léger

Context Low-dose multitarget pharmacological strategies are viewed as promising approaches for managing cognitive impairment in aging. Here, we assessed the preclinical efficacy of co-modulating the 5-HT 4 receptor-dependent cAMP pathway to improve memory. Materials and methods The individual and combined effects of …

fr (code pays fourni par la source)

Residual Effects of Acute and Subchronic Zolpidem Treatments on Attentional Processes in Aged Female Rats

Marianne Léger, Michel Boulouard, Christophe Liet, Ben Grayson et autres

RATIONAL: Zolpidem, a hypnotic Z-drug commonly prescribed to promote sleep, is predominantly used over the age of 50. In this elderly population, adverse behavioral disturbances, impaired driving performance, and an increased risk of falls have been frequently reported. These concerns have raised …

fr, gb (code pays fourni par la source)

LOU/c/jall rat as a model of resilience in the context of streptozotocin-induced cognitive impairment

Lucas Gephine, Sophie Corvaisier, Benoı̂t Bernay, Thomas Fréret et autres

Introduction: The concept of cognitive resilience (CR) has emerged to explain the lack of correlation between the extent of brain lesions and the severity of cognitive symptoms in Alzheimer's disease (AD), but the underlying mechanisms remain poorly understood. Methods: To investigate this, …

fr (code pays fourni par la source)

L’approche "Deformation-based morphometry" (DBM) est-elle pertinente pour identifier les changements macrostructuraux cérébraux radio-induits ?

Carole Brunaud, Samuel Valable, Gwenn Ropars, Fatima-Azzahra Dwiri et autres

ISTCT

fr (code pays fourni par la source)

Detection of radiation-induced brain lesions in a rat model, using deformation-based morphometry (DBM), a method involving magnetic resonance imaging (MRI)

Carole Brunaud, Samuel Valable, Gwenn Ropars, Fatima-Azzahra Dwiri et autres

ISTCT

Analyse IRM par Deformation Based Morphometry (DBM) pour la mise en évidence des altérations cérébrales radio-induites dans un modèle de rat adulte.

Carole Brunaud, Samuel Valable, Gwenn Ropars, Fatima-Azzahra Dwiri et autres

National audience

fr (code pays fourni par la source)

Deformation-based morphometry: a sensitive imaging approach to detect radiation-induced brain injury?

Carole Brunaud, Samuel Valable, Gwenn Ropars, Fatima-Azzahra Dwiri et autres

BACKGROUND: Radiotherapy is a major therapeutic approach in patients with brain tumors. However, it leads to cognitive impairments. To improve the management of radiation-induced brain sequalae, deformation-based morphometry (DBM) could be relevant. Here, we analyzed the significance of DBM using Jacobian determinants …

fr (code pays fourni par la source)

Vulnerability of Spatial Pattern Separation in 5xFAD Alzheimer’s Disease Mouse Model

Lucas Gephine, Candice M. Roux, Thomas Fréret, Michel Boulouard et autres

Background: Alzheimer's disease (AD) is the most common cause of dementia and remains incurable. This age-related neurodegenerative disease is characterized by an early decline in episodic and spatial memory associated with progressive disruption of the hippocampal functioning. Recent clinical evidence suggests that …

fr (code pays fourni par la source)

A Dual-Task Paradigm Combining Physical and Cognitive Training in Mice: Application to Aging

Elpidio Attoh-Mensah, Antoine Huret, Marianne Léger, Gilles Loggia et autres

Physical Activity (PA) is often associated with better overall health status, especially in older adults. Numerous pieces of evidence indicate that PA would be more beneficial when applied in conjunction with Cognitive Training (CT) either simultaneously (i.e., in Dual-Task [DT]) or sequentially. …

fr (code pays fourni par la source)

LOU/C/Jall rats show preserved memory performance in sporadic model of Alzheimer's disease induced by streptozotocin

Lucas Gephine, Antoine Huret, Stacy Largillière, Sophie Corvaisier et autres

International audience