Masahiro Ando

Label-Free Raman Imaging Defines Distinct Cell Populations in Human Skin

Kaori Sugiyama, Masahiro Ando, Mizuho Ishikawa, Aiko Sada et autres

Abstract Understanding cellular heterogeneity in human skin is crucial for regenerative medicine and tissue engineering. In this study, we applied label-free Raman imaging to visualize molecular features corresponding to the three-dimensional architecture of the epidermis. Spatially resolved Raman spectra, combined with multivariate …

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Author Correction: Acarbose redirects gut microbiome utilization of dietary carbohydrates to suppress anaphylaxis in mice

Kyosuke Yakabe, Yukinobu Inoue, Yuki Yanagisawa, Shungo Imai et autres

In the version of this article initially published, the name of Tanakorn Srirat was listed incorrectly (Srirat Tanakorn) and is now amended in the HTML and PDF versions of the article.

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Acarbose redirects gut microbiome utilization of dietary carbohydrates to suppress anaphylaxis in mice

Kyosuke Yakabe, Yukinobu Inoue, Yuki Yanagisawa, Shungo Imai et autres

Abstract Microbiota-accessible carbohydrates modulate host immunity by shaping gut microbial composition and metabolism. However, their role in modulating the microbiota to influence allergic responses is unclear. Here we show that a widely used antidiabetic agent, the α-glucosidase inhibitor acarbose, redirects dietary carbohydrate …

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Label-free Raman imaging defines distinct cell populations in human skin

Kaori Sugiyama, Masahiro Ando, Mizuho Ishikawa, Aiko Sada et autres

Abstract Understanding cellular heterogeneity in human skin is crucial for regenerative medicine and tissue engineering. In this study, we applied label-free Raman imaging to visualize molecular features corresponding to the three-dimensional architecture of the epidermis. Spatially resolved Raman spectra, combined with multivariate …

jp (code pays fourni par la source)

Long-Term Tofersen in SOD1 Amyotrophic Lateral Sclerosis

Timothy M. Miller, Merit Cudkowicz, Pamela Shaw, Angela Genge et autres

Importance: Approximately 2% of amyotrophic lateral sclerosis (ALS) cases are attributable to a pathogenic variant in the superoxide dismutase 1 (SOD1) gene. Tofersen, an intrathecal antisense oligonucleotide designed to reduce SOD1 protein synthesis, is the first and only approved therapy for the …

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Current genetic landscape of inherited peripheral neuropathy: A nationwide Japanese cohort study of 3329 cases

Akiko Yoshimura, Yujiro Higuchi, Masahiro Ando, Jun-Hui Yuan et autres

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CGG repeat expansions in LRP12 as a cause of motor-dominant axonal inherited peripheral neuropathies: A study of 60 Japanese cases

Takahiro Hobara, Masahiro Ando, Yujiro Higuchi, Jun-Hui Yuan et autres

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Frequent frameshift and copy number variants in patients with SACS-related neuropathy: Insights from a Japanese cohort

Jun-Hui Yuan, Yujiro Higuchi, Masahiro Ando, Akiko Yoshimura et autres

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Role of 70 °C heating on immunostimulatory effects of probiotic bifidobacteria in infant formula

Akira Sen, Sayaka Ishihara, Masahiro Ando, Riko Mishima et autres

Bifidobacteria, dominant members of the infant gut microbiota, are essential for immune system development and are commonly added to infant formula as probiotics. However, the preparation of powdered infant formulas involves dissolving the powder in hot water (>70 °C) to inhibit the …

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Single-cell Raman spectroscopic analysis of bacteroids in soybean nodules to observe the relationship between biomolecular constituents and symbiotic nitrogen fixation activity

Shunnosuke Suwa, Masahiro Ando, Takuma Kyotan, Kento Hasegawa et autres

Nitrogen fixation in soybean occurs as a result of symbiosis between the plant and rhizobia in the nodules. This process allows both the plant and the symbiont to acquire vital nutrition. To fully understand the symbiosis, many researchers have attempted to attain …

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Raman Imaging of an Amphotericin B Potentiator in Single-Cell Saccharomyces cerevisiae

Ryosuke Miyake, Masahiro Ando, Keisuke Kobayashi, Kenichiro Nagai et autres

High Resolution Image Download MS PowerPoint Slide Nectriatide, a fungal cyclotetrapeptide, was previously found to enhance the antifungal activity of amphotericin B (AmB), with nectriatide linear derivatives (NLDs) exhibiting even stronger potentiation. Although we showed that NLDs have an affinity for ergosterol …

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Tibial to ulnar nerve amplitude ratio as a marker of length-dependent neuropathy

Chikashi Yano, Tomonori Nakamura, Masahiro Ando, Yujiro Higuchi et autres

• Tibial to ulnar amplitude ratio separates acquired and inherited neuropathies. • The ratio is higher in chronic inflammatory demyelinating polyradiculoneuropathy. • Area under the curve 0.95 with 95.5% sensitivity and 85.5% specificity. To evaluate the utility of nerve conduction studies as …

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