Waise Quarni

RBM39 degrader invigorates innate immunity to eradicate neuroblastoma despite cancer cell plasticity

Shivendra Vikram Singh, Jie Fang, Hongjian Jin, Lee-Ann Van de Velde et autres

The cellular plasticity of neuroblastoma is defined by a mixture of two major cell states, adrenergic and mesenchymal, which may contribute to therapy resistance. However, how neuroblastoma cells switch cellular states during therapy remains largely unknown, and how to eradicate neuroblastoma regardless …

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RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity

Shivendra Vikram Singh, Jie Fang, Hongjian Jin, Lee-Ann Van de Velde et autres

The cellular plasticity of neuroblastoma is defined by a mixture of two major cell states, adrenergic (ADRN) and mesenchymal (MES), which may contribute to therapy resistance. However, how neuroblastoma cells switch cellular states during therapy remains largely unknown and how to eradicate …

us (code pays fourni par la source)

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor

Carolyn M. Jablonowski, Waise Quarni, Shivendra Vikram Singh, Haiyan Tan et autres

Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how pre-mRNA splicing and metabolism are orchestrated in response to oncogenic stress …

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Author Response: Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor

Jun J.J. Yang, Carolyn M. Jablonowski, Waise Quarni, Shivendra Vikram Singh et autres

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Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

Carolyn M. Jablonowski, Waise Quarni, Shivendra Vikram Singh, Haiyan Tan et autres

Abstract Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how pre-mRNA splicing and metabolism are orchestrated in response to oncogenic …

us (code pays fourni par la source)

Author Response: Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

Carolyn M. Jablonowski, Waise Quarni, Shivendra Vikram Singh, Haiyan Tan et autres

Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how pre-mRNA splicing and metabolism are orchestrated in response to oncogenic stress …

us (code pays fourni par la source)

Reviewer #2 (Public Review): Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

Carolyn M. Jablonowski, Waise Quarni, Shivendra Vikram Singh, Haiyan Tan et autres

Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how pre-mRNA splicing and metabolism are orchestrated in response to oncogenic stress …

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor

Carolyn M. Jablonowski, Waise Quarni, Shivendra Vikram Singh, Haiyan Tan et autres

Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how pre-mRNA splicing and metabolism are orchestrated in response to oncogenic stress …

us (code pays fourni par la source)

Reviewer #1 (Public Review): Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

Carolyn M. Jablonowski, Waise Quarni, Shivendra Vikram Singh, Haiyan Tan et autres

Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how pre-mRNA splicing and metabolism are orchestrated in response to oncogenic stress …

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

Carolyn M. Jablonowski, Waise Quarni, Shivendra Vikram Singh, Haiyan Tan et autres

Abstract Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how pre-mRNA splicing and metabolism are orchestrated in response to oncogenic …

us (code pays fourni par la source)

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

Carolyn M. Jablonowski, Waise Quarni, Shivendra Vikram Singh, Haiyan Tan et autres

Dysregulated pre-mRNA splicing and metabolism are two hallmarks of MYC-driven cancers. Pharmacological inhibition of both processes has been extensively investigated as potential therapeutic avenues in preclinical and clinical studies. However, how pre-mRNA splicing and metabolism are orchestrated in response to oncogenic stress …

us (code pays fourni par la source)

Abstract 5363: MicroArray-based MethylationToActivity: Advancing biological knowledges from DNA methylation profiles of patient tumors

Karissa M. Dieseldorff Jones, Waise Quarni, Daniel K. Putnam, Shivendra Vikram Singh et autres

Abstract DNA methylation (DNAm) is a relatively stable regulatory epigenetic mechanism. Although accurate DNAm classifiers have been built for early detection of cancer and subtype classifications, its transcriptional regulatory roles remain unclear. To address this challenge, we developed a deep-learning framework MethylationToActivity …

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