Jacob A. Klapper

Association between allocation out-of-sequence and organ nonuse in contemporary lung transplantation: An analysis of the United Network for Organ Sharing national registry

Haoran Jiang, Isaac S. Alderete, Benjamin R. Helmold, Oliver K. Jawitz et autres

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Lung Transplant Patient Knowledge of Gastroesophageal Reflux Disease and Foregut Risk Factors Associated With Graft Rejection

Annie L. Wang, Jacob A. Klapper, John Reynolds, Lauren Rich et autres

INTRODUCTION: Dysphagia, gastroesophageal reflux disease (GERD), and delayed gastric emptying (DGE) are foregut risk factors associated with worse lung transplant outcomes. Transplant education varies across centers, and patient awareness of these risk factors could impact treatment adherence and outcomes. METHODS: Pre- and …

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A dedicated modular system for open-chest stabilization in thoracic transplantation

Luiz Maracaja, Jacob Niall Schoroder, Jeffrey Keenan, Jacob A. Klapper et autres

Delayed chest closure is frequently required following heart and lung transplantation due to graft edema, bleeding, size mismatch, or hemodynamic instability, yet current open-chest management strategies rely largely on improvised spacers with recognized mechanical and physiologic limitations. We describe the design and …

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149. Case Video: Right Upper Double-Sleeve Lobectomy using Right Middle and Lower Lobe Autotransplantation and Pulmonary Vascular Reconstruction

Jason Leung, Hiroshi Date, Kunal Patel, Matthew Hartwig et autres

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Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients

Noah J. Timko, Mary Cooter Wright, Melody R. Smith, Piper C. Boykin et autres

Importance: The apolipoprotein E (APOE) gene ε4 allele leads to increased Alzheimer disease risk and neuroinflammation and is also believed to play a role in postoperative delirium. However, the safety and feasibility of modulating apoE protein signaling to reduce postoperative neuroinflammation and …

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Right-sided bibronchial anastomosis for lung transplantation

Jason H. Leung, Hiroshi Date, Kunal Patel, Matthew Hartwig et autres

Right upper lobe bronchus and bronchus intermedius anastomosis, compared to conventional right main bronchus anastomosis, results in shorter donor bronchial length and can reduce airway complications.

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Frailty assessment and candidate optimization before cardiothoracic transplantation

Antoine Premachandra, Jacob A. Klapper, Jonathan Messika, Maïra Gaillard et autres

Frailty is an important syndrome in an aging thoracic transplant population, particularly in the context of end-stage cardiopulmonary disease. In this review, we discuss the core problem of lack of physiologic reserve in these patients and its relationship to perioperative outcomes, how …

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An early nationwide analysis on the continuous distribution of lung-involved multiorgan transplantation

Haoran Jiang, Isaac S. Alderete, Alexandria L. Soto, Matthew Libre et autres

The impact of continuous distribution on allocation of multiorgan transplantation (MOT) involving lungs remains unexplored. Here we characterize how continuous distribution has affected lung-involved MOT. We conducted a retrospective study using the United Network for Organ Sharing database. Adults listed for lung-MOT …

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Lung transplantation from donation after circulatory death donors over 55 years old: A national analysis of outcomes and utilization

Isaac S. Alderete, Samantha E. Halpern, Oliver K. Jawitz, Atilla Gürses et autres

Background: Lungs from older donation after circulatory death (DCD) donors are underutilized; however, these organs may represent an opportunity to expand the donor pool. Herein, we evaluated utilization and outcomes of lung transplants using lungs from older DCD donors. Methods: Using national …

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Commentary: History Will Judge

Jacob A. Klapper

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Impact of Antireflux Surgery on Interstitial Lung Disease and Lung Transplantation

Tommi Järvinen, Jacob A. Klapper, Matthew G. Hartwig

Gastroesophageal reflux disease (GERD) is a prevalent problem in patients with interstitial lung disease (ILD) before or after lung transplantation. It has been linked to the pathogenesis of ILD, but the precise nature of this relationship remains unclear. Antireflux surgery has shown …

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Resection of Intrapericardial Lymphangioma Invasive to Ventricular Apex via Left Anterolateral Thoracotomy

Samuel J. Kesseli, Jacob A. Klapper, Louis R. DiBernardo, Han W. Kim et autres

Here we describe a case of an intrapericardial mass identified in a patient with endocarditis and severe mitral regurgitation. Despite preoperative imaging suggestive of a pericardial origin, intraoperatively the mass was found to invade the apical ventricular myocardium. The mass was resected …

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