Yong-Da Liu

STING Modulating ER ‐Phagy in the Prelimbic Cortex Neurons Contributed to Neuropathic Pain and Emotional Comorbidity

Yong-Da Liu, X J Yang, Shihui Kuai, X M Chen et autres

BACKGROUND: Our previous data suggested that autophagy is crucial for neuropathic pain. The different cell types and varying degrees of regulation of STING may lead to a paradoxical effect on pain and emotions in the neuropathic pain model. Up to now, whether …

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Mitochondria-Targeted Metal Polyphenol Networks Inhibit Crystalline Nephropathy by Modulating SerpinE1 and Remodeling the Pathological Mineralization Microenvironment

Xuewu Chen, Jun Long, Xiao-Peng Zheng, Bang‐Xian Yu et autres

Crystalline nephropathy is driven by a self-perpetuating cycle in which crystal-induced tubular injury promotes further nucleation, growth, and aggregation, transforming the kidney into a pathological mineralization niche. Conventional therapies fail to disrupt this vicious loop, while nanomedicines are hindered by the glomerular …

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Modulation of Pain Sensitivity by the Locus Coeruleus–Paraventricular Thalamic Nucleus–Anterior Cingulate Cortex Pathway in Mice

Shihui Kuai, Zijie Li, Ziyi Wu, Yong-Da Liu et autres

BACKGROUND: Noradrenergic projections from the locus coeruleus (LC) to the thalamus and anterior cingulate cortex (ACC) contribute to pain-like behaviors, yet their hierarchical organization remains unclear. This article examines how locus coeruleus-derived norepinephrine inputs to the paraventricular thalamic nucleus (PVA) and ACC …

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Therapeutic potential of Desmodium styracifolium polysaccharide in attenuating nano-calcium oxalate induced renal injury and fibrosis

Bang‐Xian Yu, Jun Long, Quan Zhang, Yang Liu et autres

Calcium salt deposition in the kidney induces epithelial-to-mesenchymal transition (EMT) in renal tubular epithelial cells, which is the pathological basis for the progression to renal fibrosis in patients with renal stones; however, effective drugs to prevent and treat this disease have not …

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Effect of multiple-tract mini-percutaneous nephrolithotomy on kidney function for the treatment of renal complex stones

Fuyang Lin, Renfei Liu, Hao Wang, Chao Cai et autres

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TGF-β1/IL-11 positive loop between renal tubular epithelial cell and fibroblast promotes the ectopic calcification of renal interstitial fibroblasts in rats

Jinghua Zhong, Xiaolu Duan, Houmeng Yang, Zezhen Liu et autres

Randall's plaque (RP) is one of the key causes of calcium oxalate (CaOx) kidney stones formation and recurrence characterized by osteogenic differentiation and fibrosis in renal papilla area. Previous studies have found that IL-11 could promote the osteogenesis of fibroblasts and function …

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Nomogram for predicting risk factors of postoperative residual stones in patients after pure ultrasonography-guided access mini-percutaneous nephrolithotomy

Fuyang Lin, Chao Cai, Huan Deng, Jianpeng Zhang et autres

BACKGROUND: Some urologists prefer to perform PCNL by using pure ultrasonography-guided access (USGA), but some potential factors that may cause the residual stones need to be excavated. This retrospective case-control study is designed to confirm the risk factors for residual stones after …

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Association between kidney stones and urological cancers: results from the NHANES 2007–2020 and Mendelian randomization study

Jinghua Zhong, Jiahao Cheng, Zhijian Zhao, Houmeng Yang et autres

BACKGROUND: Kidney stones is a common urological disease with a rising incidence in global. The association between kidney stones and urological cancers remains controversial. This study utilized the data from the 2007-2020 National Health and Nutrition Examination Survey (NHANES) and Mendelian randomization …

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Therapeutic Potential of Desmodium styracifolium Polysaccharide in Attenuating Nano-Calcium Oxalate Induced Renal Injury and Epithelial-to-Mesenchymal Transition

Xin‐Yuan Sun, Bang‐Xian Yu, Linghong Huang, Quan Zhang et autres

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Hydroxycitric acid inhibits ectopic calcification of renal interstitial fibroblasts by suppressing cell apoptosis

Weifeng Liu, Yi-Han Zhang, Xiaopeng Zheng, Quan Zhang et autres

• Calcification was identified in Randall's plaque. • Calcification-related proteins were up-regulated in animal and cell models. • HCA reduces calcification-induced apoptosis and oxidative damage. • HCA inhibits cellular calcification and deposition of calcium salts in animals. Ectopic calcification of the renal …

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Dexmedetomidine and Ketamine Attenuated Neuropathic Pain Related Behaviors via STING Pathway to Induce ER-Phagy

Yong-Da Liu, Shihui Kuai, Mengmeng Ding, Zhibin Wang et autres

Our previous work indicated that ER-phagy level had altered in spinal nerve ligation (SNL) rats. In this study, we investigated whether dexmedetomidine or ketamine exhibits anti-anxiety or anti-nociceptive effects via modulation of the spinal STING/TBK pathway to alter ER-phagy in SNL rats. …

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高頻度脊髄刺激は脊髄後角におけるリソソーム機能と自己貪食性フラックスの回復により長期持続性鎮痛作用を生じる【JST・京大機械翻訳】

Wang Zhibin, Yong-Da Liu, Wang Shuo, Zhao Ping