Haiyan Zhao

Impact of intimate partner violence on in vitro fertilization outcomes among infertile women: a retrospective cohort study

Xuran Wang, Hongwei Yan, Cui Li, Yuhuan Feng et autres

Background Intimate partner violence (IPV) is a major public health concern that disproportionately affects women, yet its impact on assisted reproductive outcomes remains insufficiently understood. This study aimed to assess the 12-month prevalence of IPV among infertile women and to evaluate its …

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Association between adverse pregnancy outcomes and incidence of advanced cardiovascular-kidney-metabolic disease: a population-based cohort study

Yifan Wang, Changhao Zu, Dantong Wang, Nandi Liu et autres

Objective: Adverse pregnancy outcomes (APOs) are independent risk factors for cardiovascular disease in women. Within the novel cardiovascular-kidney-metabolic (CKM) framework, evidence linking APOs to advanced CKM (stages 3-4) remains limited. Methods: This study used data from the Kailuan Cohort and combined cross-sectional …

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Antigenic landscape of Nipah virus attachment glycoprotein analysis reveals a protective immunodominant epitope across species

Dan Zhou, Yong Wang, Yanfeng Yao, Wenhua Kuang et autres

Nipah virus (NiV) and Hendra virus (HeV), two highly pathogenic Henipaviruses (HNVs), pose a significant public health threat. The attachment glycoprotein (G) plays a crucial role in viral attachment and entry, making it an attractive target for vaccine and therapeutic antibody development. …

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NSUN2-dependent 5-methylcytosine Modification Regulates Influenza A virus Gene Expression and Genomic Packaging

Jing Hu, Shengqiang Jiang, Wanling You, Ruiwei Hao et autres

Abstract Emerging evidence indicates that methyltransferase NSUN2 catalyzes 5-methylcytosine (m 5 C) modifications on various viral RNAs and plays important roles in viral biology. However, the regulatory roles of NSUN2 in influenza A virus (IAV) replication have not been elucidated. Here, we …

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Factors related to quality of life in caregivers of children with autism spectrum disorder: emphasizing challenges in the context of Eastern China

Xu Chen, Tong Jiao, Xue Wang, Lu Zhu et autres

BACKGROUND: Caregivers of children with autism spectrum disorder (ASD) encounter multiple challenges, increasing their risk of experiencing a low quality of life (QOL). Therefore, this study aims to examine the QOL among caregivers of children with ASD in eastern China and to …

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Structure and function of the nairovirus cap-snatching endonuclease

Wenhua Kuang, Gan Zhang, Fan Wu, Jinyue Li et autres

Abstract Nairoviruses include several human pathogens such as Crimean-Congo hemorrhagic fever virus (CCHFV) and Kasokero virus (KASV). The cap-snatching endonuclease (EN) domain of the viral polymerase is essential for transcription and represents a promising antiviral target. However, the structural and functional mechanisms …

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Broadly Sarbecovirus-Neutralizing Antibodies Induced by Ancestral SARS-CoV-2 Infection

Y. T. Zhang, Zhen Zhang, Feiyang Yu, Xianying Chen et autres

The COVID-19 pandemic, driven by SARS-CoV-2, continues to challenge global health due to emerging variants and the potential risk posed by related sarbecoviruses. Neutralizing antibodies targeting the spike (S) glycoprotein, particularly the receptor-binding domain (RBD), play a crucial role in viral neutralization …

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Author response for "Examining Brain Function Changes in HIV‐Infected Patients With Asymptomatic Neurocognitive Impairment: A Longitudinal Study"

Juming Ma, Zhongkai Zhou, Shuai Han, Chuanke Hou et autres

Infantile pyknocytosis: A rare, but not exceptional, cause of hemolytic anemia

Menglu Wu, Haiyan Zhao, Peng Sun, Xiangmao Bu et autres

Infantile karyopyknosis (IP) is a form of hemolytic anemia that is characterized by an increase in the number of pyknocytes in blood, which were initially described by Drs. Tuffy, Brown, and Zuelzer in 1959 [1]. The pyknocyte is a highly distorted, completely …

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The HAVCR1-centric host factor network drives Zika virus vertical transmission

Wenzhe Yu, Jun Tao, Hongmin Cao, Wanshan Zheng et autres

Zika virus (ZIKV) vertical transmission results in devastating congenital malformations and pregnancy complications; however, the specific receptor and host factors facilitating ZIKV maternal-fetal transmission remain elusive. Here, we employ a genome-wide CRISPR screening and identify multiple placenta-intrinsic factors modulating ZIKV infection. Our …

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Corrigendum to “IgA class switching enhances neutralizing potency against SARS-CoV-2 by increased antibody hinge flexibility” [Antiv. Res. (2025) 106082]

Mengxin Xu, Zhaoyong Zhang, Yuzhu Sun, Haoting Mai et autres

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Neutralizing antibodies elicited by Nipah virus G-head nanoparticle target diverse sites and inhibit receptor binding and fusion

Dan Zhou, Yong Wang, Yanfeng Yao, Wenhua Kuang et autres

Abstract Nipah virus (NiV) and Hendra virus (HeV), two highly pathogenic Henipaviruses (HNVs), pose a significant public health threat. The attachment glycoprotein (G) plays a crucial role in viral attachment and entry, making it an attractive target for vaccine and therapeutic antibody …

cn (code pays fourni par la source)