Hitendra Shaligram Mahajan

Mesoporous Silica Nanoparticles for Improved Solubility and Bioavailability of Pazopanib in the Treatment of Renal Cell Carcinoma

Minal Patil, Suprit Dilip Saoji, Ashish Gaikwad, Chandragouda Raosaheb Patil et autres

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Nasal Delivery of Nanoemulsion Containing a Synergistic Combination of Curcumin and Gefitinib for Brain Tumor Targeting

Sagar Kishor Savale, Sachin Maroti Chandankar, Hitendra Shaligram Mahajan

Tocofersolan micelles for improved solubility and oral bioavailability of ritonavir

Hitendra Shaligram Mahajan, Payal Hasmukhlal Patil, Dipak Dhanraj Patil, Prafull Bandopant Ninave et autres

This study focused on the development of ritonavir-loaded tocofersolan polymeric micelles (RV-TCF-PM) to enhance the solubility and oral bioavailability of ritonavir. It is a BCS Class II HIV-1 protease inhibitor with low and variable oral bioavailability due to poor aqueous solubility, P-glycoprotein …

Unveiling Alzheimer’s disease (1901–2025): Historical insights, global burden, biological mechanisms, diagnostics, and therapeutic strategies

Premkumar S. Baviskar, Hitendra Shaligram Mahajan

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Intranasal carvacrol nanoemulsion: Stroke imaging and neuroprotective study

Hitendra Shaligram Mahajan, Ghanshyam Girnar

Background and purpose: Cerebral ischemia causes neuronal damage due to restricted blood flow and presents significant challenges for brain-targeted drug delivery because of the blood-brain barrier. The purpose of this study is to formulate and evaluate an intranasal oil-in-water nanoemulsion of carvacrol, …

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Biotin functionalized chitosan nanoparticle containing L-carnosine as dry powder for inhalation

Pradeep S. Patil, Hitendra Shaligram Mahajan

L-carnosine, a dipeptide, has attracted considerable attention for its potential anticancer properties. This study employed the ionic gelation method to prepare L-carnosine-loaded chitosan nanoparticles (CSNPs), which were subsequently surface-functionalized with biotin to enable targeted delivery to lung cancer cells. The resulting nanoparticles …

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A Comprehensive Review of Nanoemulsion Via the Nose To the Brain in the Management of Parkinson’s Disease

Hitendra Shaligram Mahajan, Rahul J. Sarode, Subhash Vishwanath Deshmane, Ghanshyam Girnar et autres

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THERMORESPONSIVE IN-SITU GELLING OPHTHALMIC DRUG DELIVERY SYSTEM BASED ON XYLOGLUCAN CONTAINING TRIAMCINOLONE ACETONIDE NANOPARTICLES

Yogesh Sonar, Hitendra Shaligram Mahajan

This investigation explores the feasibility of using a gel formulation composed of xyloglucan for the administration of triamcinolone acetonide (TA) nanoparticles in ophthalmic drug delivery systems. The solvent evaporation method with lyophilization was employed to develop TA-loaded β-cyclodextrin (βCD)-Soluplus (Solu) nanoparticles (NPs), …

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Ketoconazole-loaded nanoemulsion in situ gel system for ocular delivery: development and evaluation

Shivani Makhijani, Pankaj Padmakar Nerkar, Hitendra Shaligram Mahajan

This study deals with the development of nanoemulsion containing ketoconazole loaded in situ gel system for ocular delivery, followed by in vitro and ex vivo, evaluations. Nanoemulsion formulation was characterized by globular size, polydispersity index, pH, zeta potential, and drug content. In …

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Pharmaceutical application of beta-glucan: a comprehensive overview

Pooja Anand Mundada, Hitendra Shaligram Mahajan

Abstract Background Beta-glucan (BG) is a diverse group of polysaccharides widely distributed in nature, including fungi, algae, bacteria, and cereals. Due to its unique physicochemical and biological properties, BG has gained significant attention in various fields, such as pharmaceuticals, cosmetics, nutraceuticals, and …

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Investigating postbiotics as innovative adjuvants: deciphering the gut-breast connection in breast Cancer therapy, from gut microbiome to personalized medicine

Rashmi Ghosh, Debayan Sil, Rohit R. Sharma, Dinesh Kumar et autres

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Polysaccharides from Nature to Technology: Grafting Techniques and their Applications

Hitendra Shaligram Mahajan, Meghraj Vivekanand Suryawanshi, Rahul J. Sarode, Pranjal P. Gujarathi

Abstract: Polysaccharides, naturally occurring and renewable biopolymers, have garnered significant attention due to their structural versatility and wide-ranging applications across the biomedical, pharmaceutical, and industrial sectors. This review explores the role of polysaccharides as excipients and their emerging importance in drug delivery …

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