Atsushi Yamaguchi

Clinical outcomes and recurrence patterns in pancreatic ductal adenocarcinoma diagnosed at an early stage: insights from a multicenter cohort study in Japan

Juri Ikemoto, Yasutaka Ishii, Keiji Hanada, Tamito Sasaki et autres

BACKGROUND: The prognosis and recurrence patterns of early-diagnosed pancreatic ductal adenocarcinoma (PDAC), particularly following surgical resection, remain unclear. METHODS: This multicenter retrospective study analyzed patients who underwent surgical resection for PDAC between 2005 and 2023. Patients were categorized according to pathological stages …

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Clinical Profile and Predictors of Repeated Relapse in Type 1 Autoimmune Pancreatitis: A Multicenter Observational Study

Sho Saeki, Yasutaka Ishii, Keiji Hanada, Tamito Sasaki et autres

BACKGROUND AND AIM: Type 1 autoimmune pancreatitis (AIP) is a form of pancreatitis that responds well to glucocorticoid therapy and often results in clinical and radiological remission. However, AIP frequently relapses during long-term follow-up. While initial relapse is well described, repeated relapses …

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Clinicopathological features of type 1 autoimmune pancreatitis without elevated serum IgG4 level

Yumiko Yamashita, Yasutaka Ishii, Keiji Hanada, Tamito Sasaki et autres

Elevated serum IgG4 is a key diagnostic marker for type 1 autoimmune pancreatitis (AIP), but some patients lack IgG4 elevation, complicating diagnosis. This study investigated the clinicopathological features of AIP without elevated serum IgG4 levels. A total of 323 patients diagnosed with …

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Metastatic pancreatic acinar cell carcinoma with BRCA2 gene alternation resected after modified FORFIRINOX therapy: a case report and literature review

Shuhei Sugata, Atsushi Yamaguchi, Hiroki Kamada, Shigeaki Semba et autres

Background: gene alternation whose hepatic metastasis was shrunk by a treatment with a modified FORFIRINOX (mFFX) regimen. The patient also underwent conversion surgery after the mFFX treatment. Case Description: gene alternation was identified, and mFFX was continued. He had considerable tumor shrinkage …

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A case of chronic hepatitis B complicated by systemic sarcoidosis that regressed following nucleos(t)ide analog therapy

Shigeaki Semba, Yuji Teraoka, Hiroki Kamada, Naohiro Kato et autres

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High-grade biliary intraepithelial neoplasia localized in the distal bile duct diagnosed via peroral cholangioscopy: A rare case report

Naohiro Kato, Atsushi Yamaguchi, Hiroki Kamada, Shigeaki Semba et autres

RATIONALE: Biliary intraepithelial neoplasm (BilIN) is characterized by a microscopically identifiable preinvasive neoplasm of the biliary tract. BilIN is rarely diagnosed intentionally and is often detected incidentally in surgical specimens obtained via surgical resection for other types of cancers. Herein, we report …

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A case of pancreatic acinar cell carcinoma implantation in multiple branches of the pancreatic duct without main tumor continuity: a rare case report

Atsushi Yamaguchi, Hiroki Kamada, Shigeaki Semba, Naohiro Kato et autres

Background: Pancreatic acinar cell carcinoma (PACC) is a rare subtype of pancreatic cancer and the clinicopathological behavior of PACC is not yet fully understood. PACC rarely invades the main pancreatic duct (MPD), which causes intraductal growth. Thus, herein, we have reported a …

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Bilateral Coronary Malperfusion due to Type A Acute Aortic Dissection Treated with Veno-Arterial Extracorporeal Membrane Oxygenation/Impella5.5 After Intraoperative Reversal of Apixaban-Mediated Anticoagulation by Andexanet Alfa

Minoru Kowada, Homare Okamura, Hidenori Kariya, Rie Iwasaki et autres

Patients with acute type A aortic dissection complicated by bilateral coronary malperfusion have a poor prognosis.Mechanical heart-assist devices are often used in the management of post-cardiotomy cardiogenic shock.However, the anticoagulation therapy regimen and device insertion site selection pose challenges and are subject …

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Morphological characteristics and outcomes of aortic repair of acute type A aortic dissection occurring in patients with aortic arch branching variants

Takahiro Yamamoto, Naoyuki Kimura, Daijiro Hori, Makiko Mieno et autres

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Effectiveness and safety of a new clip for delivery using a duodenoscope for bleeding after endoscopic sphincterotomy

Atsushi Yamaguchi, Hiroki Kamada, Shigeaki Semba, Naohiro Kato et autres

Abstract Background and study aims Hemostasis for post-endoscopic sphincterotomy (post-EST) bleeding involves no standard strategy. New clips designed for delivery using the duodenoscope (SureClip, Micro-Tech, Nanjing, China) have been utilized for gastrointestinal bleeding hemostasis and bleeding prevention after polypectomy and papillectomy. We …

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Progesterone improves motor coordination impairments caused by postnatal hypoxic-ischemic brain insult in neonatal male rats

Hongying Piao, Hiroshi Ishikawa, Tatsuya Kobayashi, Keiko Kitajo et autres

BACKGROUND: Hypoxic-ischemic (HI) insult in infants induces brain injury and results in motor coordination impairments associated with cerebral palsy; however, preventive measures for HI brain injury in preterm infants remain unclear. We investigated the impact of progesterone (P4) in a rat HI …

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OUTCOME OF COLORECTAL STENTING AS BRIDGE TO SURGERY IN ELDERLY PATIENTS

Takeshi Mizumoto, Toshio Kuwai, Shigeaki Semba, Naohiro Kato et autres