Clinical outcomes and recurrence patterns in pancreatic ductal adenocarcinoma diagnosed at an early stage: insights from a multicenter cohort study in Japan
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The prognosis and recurrence patterns of early-diagnosed pancreatic ductal adenocarcinoma (PDAC), particularly following surgical resection, remain unclear. METHODS: This multicenter retrospective study analyzed patients who underwent surgical resection for PDAC between 2005 and 2023. Patients were categorized according to pathological stages 0, I, and II. Recurrence patterns and survival outcomes were compared among the three groups. Multivariate analysis was performed to identify independent risk factors for remnant pancreatic recurrence, including early-stage disease, postoperative follow-up of more than 5 years, and receipt of adjuvant chemotherapy. RESULTS: A total of 349 patients were included: 51 with stage 0, 77 with stage I, and 221 with stage II PDAC. The 5-year overall survival rates were 87%, 71%, and 49% for patients with stage 0, I, and II PDAC, respectively. Remnant pancreatic recurrence was observed in 10% of patients with stage 0 PDAC and 18% of patients with stage I PDAC, compared with 5% of those with stage II PDAC. Recurrence was significantly more frequent in stage I (P < 0.001) and tended to be higher in stage 0 (P = 0.062) than in stage II. Multivariate analysis identified pathological stage 0-I and postoperative follow-up of > 5 years as independent risk factors for remnant pancreatic recurrence. CONCLUSIONS: Patients with early-stage PDAC exhibit a higher risk of remnant pancreatic recurrence than those with stage II disease. These findings underscore the importance of long-term pancreas-focused surveillance in early-stage PDAC to enable timely detection of late recurrence and potentially improve patients outcomes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical outcomes and recurrence patterns in pancreatic ductal adenocarcinoma diagnosed at an early stage: insights from a multicenter cohort study in Japan
- Date Crossref
- 03/01/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Hiroshima University Department of Anatomical Pathology pays non établi dans la noticeUniversité ou école supérieure
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Onomichi General Hospital Department of Gastroenterology pays non établi dans la noticeÉtablissement de santé
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Hiroshima Prefectural Hospital Department of Gastroenterology pays non établi dans la noticeÉtablissement de santé
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Hiroshima General Hospital Department of Gastroenterology pays non établi dans la noticeÉtablissement de santé
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Kure Medical Center Department of Gastroenterology pays non établi dans la noticeÉtablissement de santé
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Kure Kyosai Hospital Department of Gastroenterology pays non établi dans la noticeÉtablissement de santé
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Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital pays non établi dans la noticeÉtablissement de santé
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Hiroshima City Asa Citizens Hospital pays non établi dans la noticeÉtablissement de santé
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Higashihiroshima Medical Center Department of Gastroenterology pays non établi dans la noticeÉtablissement de santé
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Chugoku Rosai Hospital Department of Gastroenterology pays non établi dans la noticeÉtablissement de santé
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Hiroshima University Hospital pays non établi dans la noticeÉtablissement de santé
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Graduate School of Biomedical and Health Sciences Department of Gastroenterology pays non établi dans la noticeUniversité ou école supérieure
Department of Anatomical Pathology — Hiroshima University, Department of Gastroenterology — Onomichi General Hospital et Department of Gastroenterology — Hiroshima Prefectural Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.