Aleksandra Stefanović

Resistance of Borrelia burgdorferi Sensu Lato Isolates from Serbia to Human Complement

Gorana Veinović, Sanja Ćakić, Darko Mihaljica, Ratko Sukara et autres

Serbia is characterised by the high prevalence and diversity of Borrelia burgdorferi sensu lato strains in ticks, but the reported incidence of Lyme borreliosis is much lower than that in regions with a similar prevalence of Borrelia in ticks. To evaluate the …

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Phospholipid transfer protein: The link between lipid metabolism and inflammation in healthy pregnancy and pregnancy with cardiometabolic complications

Marko Stanković, Jelena Munjas, Minja Derikonjic, Aleksandra Zeljković et autres

Background: Phospholipid transfer protein (PLTP) regulates high-density lipoprotein (HDL) remodelling by transferring cholesterol and phospholipids and affecting particle size and function. Pregnancy alters lipid metabolism, but the adaptation of PLTP to pregnancy remains poorly understood. This study investigated longitudinal changes in PLTP …

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Hidden Industrial Trans-Fatty Acids: Mechanistic Insights into Dyslipidemia, Cardiovascular Disease, and Metabolic Dysfunction-Associated Steatotic Liver Disease

Mona A Hegazy, Bojana B. Vidović, Shimaa Abobakr, Aleksandra Zeljković et autres

Trans-fatty acids (TFAs), particularly industrially produced TFAs (iTFAs), are linked to dyslipidemia, cardiovascular disease (CVD), and metabolic dysfunction-associated steatotic liver disease (MASLD). Despite regulatory efforts, "hidden" TFAs persist in processed foods, posing ongoing health risks. This narrative review synthesizes evidence on the …

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Integrative prediction models of gestational diabetes mellitus: Insights from lipidomic profiling

Marija Sarić Matutinović, Milica Miljkovic Trailovic, Tamara Antonić, Sandra Vladimirov et autres

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From genetic data to kinship clarity: employing machine learning for detecting incestuous relations

Dejan Šorgić, Aleksandra Stefanović, Mladen Popović, Dušan Keckarević

Introduction: The aim of the study was to develop a predictive model based on STR profiles of mothers and children for the detection of incestuous conception. Methods: Based on allele frequency data from the USA and Saudi Arabia, STR profiles were generated …

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Associations of excessive gestational weight gain with changes in components of maternal reverse cholesterol transport and neonatal outcomes

Minja Derikonjic, Jelena Vekić, Aleksandra Stefanović, Marija Sarić Matutinović et autres

Excessive gestational weight gain may be associated with unfavorable pregnancy outcomes. We explored the impact of excessive weight gain on components of HDL metabolism in maternal plasma: sterol composition of HDL particles, distribution of HDL subclasses and SCARB1 , ABCA1 and ABCG1 …

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Unraveling sphingolipid dynamics in late-onset preeclampsia: insights from lipidomic analysis

Aleksandra Stefanović, Aleksandra Zeljković, Tamara Gojković, Tamara Antonić et autres

Introduction: Sphingolipids, essential to trophoblast and endothelial function, may impact inflammation in preeclampsia. However, their specific role in late-onset preeclampsia remains unclear. To address this research gap, we analyzed sphingolipid profiles in pregnancies at high risk for preeclampsia development to identify potential …

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Predictive analysis of lipidome patterns in gestational diabetes mellitus risk assessment

Marija Sarić Matutinović, Aleksandra Zeljković, Jelena Vekić, Daniela Ardalić et autres

Lipid predictors of gestational diabetes mellitus 1 with special emphasis on lipoprotein distribution, NCSs, and sphingolipids. Patients and methods Study participantsThis longitudinal study was a part of a larger research project HI -MOM (High -density lipoprotein metabolome research to improve pregnancy outcome).It …

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Monocyte/HDL-cholesterol ratio as an early prognostic marker of pregnancy complications development

Jovana Vulić, Jelena Radojković, Jelena Vekić, Aleksandra Stefanović et autres

Pregnancy complications increase the long-term cardiovascular risk for both the mother and the child. Inflammation is a common mechanism underlying the development of pregnancy complications and atherosclerosis. This study aims to investigate whether the monocyte/HDL cholesterol ratio can serve as a predictive …

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Association between systemic inflammation and lipid metabolism in the development of preeclampsia

Tamara Gojković, Daniela Ardalić, Gorica Banjac, Jelena Vekić et autres

Preeclampsia (PE) is a pregnancy complication marked by hypertension (≥ 140/90 mmHg) and proteinuria (≥ 300 mg/24 h), with an unclear pathogenesis involving inflammation and dyslipidemia. This study aimed to longitudinally examine changes in lipid status parameters and inflammatory markers in pregnant …

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XGBoost as a reliable machine learning tool for predicting ancestry using autosomal STR profiles - Proof of method

Dejan Šorgić, Aleksandra Stefanović, Dušan Keckarević, Mladen Popović

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Retrospective analysis of isolated respiratory pathogens spectrum and antimicrobial resistance trends: a single center ten-years follow-up

Desa Nastasijević Borovac, Borislav Božanić, Tatjana Pejčić, Marija Topalović et autres

Introduction: Bacterial resistance to antibiotics represents one of the biggest therapeutic problems resulting in increased morbidity and mortality, as a consequence of irrational antibiotic use and rapid bacterial adaptation. Aims and objectives: We aimed to asses our local respiratory pathogens spectrum and …

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