Valerie Ann Perez

A Conserved 3′UTR Stem–loop Directs UPF1/eIF4AIII-Dependent Regulation of GABARAPL1 mRNA

Maëlys Baudin, Francesca Fiorini, Cécilia Hognon, Jules Durand et autres

RNA-binding proteins (RBP) interact with mRNA untranslated regions containing cis-regulatory elements to govern mRNA localization, stability, and translational efficiency. Among these trans-regulatory factors, RNA helicase UPF1 is a central factor which play a role in multiple mRNA decay pathways, including nonsense-mediated mRNA …

fr (code pays fourni par la source)

GABARAPL1 is important for the activation of HRI during eIF2α phosphorylation-dependent stress response to sodium arsenite

Sarah Campenet, Mathis Lamarre, Jules Durand, Valerie Ann Perez et autres

Sodium arsenite is known to activate the integrated stress response pathway, through the activation of the heme-regulated inhibitor kinase (HRI). Upon activation, HRI phosphorylates the α subunit of the translation initiation factor eIF2, resulting in cap-dependent translation arrest. As a consequence, untranslated …

fr (code pays fourni par la source)

Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context

Sofia Bali, Paweł M. Wydorski, Ruhar Singh, Nico A. J. van Nuland et autres

us (code pays fourni par la source)

Texture profile analysis and rheology of plant-based and animal meat

Reese A. Dunne, Ethan C. Darwin, Valerie Ann Perez, Marc E. Levenston et autres

• To mimic animal meat, plant-based meat must match mouthfeel, taste, and texture. • To quantify texture, we tested eight meats using texture profile analysis and rheology. • Sample stiffnesses varied from 419 kPa for plant-based turkey to 57 kPa for tofu. …

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Functional classification of tauopathy strains reveals the role of protofilament core residues

Jaime Vaquer‐Alicea, Victor A. Manon, Vaibhav Bommareddy, Peter Kunach et autres

Distinct tau amyloid assemblies underlie diverse tauopathies but defy rapid classification. Cell and animal experiments indicate tau functions as a prion, as different strains propagated in cells cause unique, transmissible neuropathology after inoculation. Strain amplification requires compatibility of the monomer and amyloid …

us (code pays fourni par la source)

Hemolymph microbiota and immune effectors’ expressions driven by geographical rearing acclimation of the aquacultured Penaeus stylirostris

Valerie Ann Perez, Viviane Boulo, Julien de Lorgeril, Dominique Pham et autres

BACKGROUND: In holobiont, microbiota is known to play a central role on the health and immunity of its host. Then, understanding the microbiota, its dynamic according to the environmental conditions and its link to the immunity would help to react to potential …

nc, fr, re, pf (code pays fourni par la source)

Amyloid-Motif-Dependent Tau Self-Assembly is Modulated by Isoform Sequence Context

Sofia Bali, Ruhar Singh, Paweł M. Wydorski, Nico A. J. van Nuland et autres

us, es (code pays fourni par la source)

Chemical inhibition of eIF4A3 abolishes UPF1 recruitment onto mRNA encoding NMD factors and restores their expression

Jules Durand, Annick Fraîchard, Valerie Ann Perez, Éric Hervouet et autres

fr (code pays fourni par la source)

Texture profile analysis and rheology of plant-based and animal meat

Reese A. Dunne, Ethan C. Darwin, Valerie Ann Perez, Marc E. Levenston et autres

Abstract Plant-based meat can help combat climate change and health risks associated with high meat consumption. To create adequate mimics of animal meats, plant-based meats must match in mouthfeel, taste, and texture. The gold standard to characterize the texture of meat is …

us (code pays fourni par la source)

Functional classification of tauopathy strains reveals the role of protofilament core residues

Jaime Vaquer‐Alicea, Victor A. Manon, Vaibhav Bommareddy, Peter Kunach et autres

Abstract Distinct tau amyloid assemblies underlie diverse tauopathies but defy rapid classification. Cell and animal experiments indicate tau functions as a prion, as different strains propagated in cells cause unique, transmissible neuropathology after inoculation. Strain amplification requires compatibility of the monomer and …

us (code pays fourni par la source)

Abstract 2445 Elucidating Tau Fibril Formation using Correlative Cryo-CLEM in situ

Sarah H. Shahmoradian, Jim Monistrol, Hung Tri Tran, Valerie Ann Perez et autres

Accurate modeling of tau protein aggregation in diverse cell systems, such as fluorescently tagged tau-expressing cell lines or 'biosensor' cells, is crucial for advancing tauopathy research. This encompasses understanding the early stages of tau fibril formation and localization within these cells, a …

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Ensemble-based design of tau to inhibit aggregation while preserving biological activity

Łukasz A. Joachimiak, Sofia Bali, Ruhar Singh, Paweł M. Wydorski et autres

us (code pays fourni par la source)