Ellen Chen

Targeted replacement of human γδ TCR in mice enhances antigen-specific B cell immunity

Husheem Michael, Michael Pitre, Gene W. Weng, Mikaela M. Vallas et autres

. In this study, we assessed the adaptive and humoral immune responses of γδ HuTCR-T1 mice compared with wild-type (WT) counterparts following immunization with collagen and keratin antigens. γδ HuTCR-T1 mice exhibited markedly enhanced B cell activity, as demonstrated by a significant …

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A 3D tumorwide multi-omic atlas of intratumoral heterogeneity in IDH -mutant glioma.

Benjamin Lerman, Olivia Doyle, Ellen Chen, Lee Chen et autres

2067 Background: Isocitrate dehydrogenase mutant (IDHmut) glioma affects over 20,000 adults per year. Treatment failure often results from intratumoral heterogeneity, in which genomic subclones undergo selection for treatment-resistant populations. Understanding this heterogeneity is critical to selecting therapeutic combinations that are efficacious across …

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EXTH-77. An AI-engineered bioPROTAC reverses immortality of TERT promoter mutant tumors

Nicholas Stevers, Ellen Chen, Joshua H. Wu, Trishna S. Patel et autres

Abstract Telomerase Reverse Transcriptase promoter (TERTp) mutations enable tumor cell immortality in millions of cancer patients annually. TERTp mutations are the most common non-coding mutations across all cancers, including glioblastoma, oligodendroglioma, medulloblastoma, and high-grade meningioma. A multitude of TERTp mutations, including the …

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The Cytotoxic Potential of Humanized γδ T Cells Against Human Cancer Cell Lines in In Vitro

Husheem Michael, Abigail T. Lenihan, Mikaela M. Vallas, Gene W. Weng et autres

Cancer is a major global health issue, with rising incidence rates highlighting the urgent need for more effective treatments. Despite advances in cancer therapy, challenges such as adverse effects and limitations of existing treatments remain. Immunotherapy, which harnesses the body’s immune system …

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Metabolomics analysis reveals resembling metabolites between humanized γδ TCR mice and human plasma

Husheem Michael, Gene W. Weng, Mikaela M. Vallas, Douglas Lovos et autres

Gamma delta (γδ) T cells, which reside in mucosal and epithelial tissues, are integral to immune responses and are involved in various cancers, autoimmune, and infectious diseases. To study human γδ T cells to a translational level, we developed γδ humanized TCR-T1 …

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Metabolomics analysis reveals resembling metabolites between humanized γδ TCR mice and human plasma

Husheem Michael, Gene W. Weng, Mikaela M. Vallas, Douglas Lovos et autres

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69. Efficient clinical review of complex NGS tumor copy number profiles using ACMG/CGC guidelines and an interactive web app

Ellen Chen, Jinlian Wang, Robert Kueffner, Hussam Al‐Kateb et autres

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CNA Explorer and anaLyzer (CNAEL): an interactive web application and standard operating procedure enabling efficient clinical review and reporting of complex NGS-derived tumor copy number profiles

Ellen Chen, Jinlian Wang, Robert Kueffner, Hussam Al‐Kateb et autres

Abstract Purpose Clinical analysis and reporting of somatically acquired copy number abnormalities (CNAs) detected through next-generation sequencing (NGS) is time consuming and requires significant expertise. Interpretation is complicated by other classes of variants such as coding mutations and gene fusions. Recent guidelines …

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