Michelle Kanther

Identification and characterization of host-modulating effectors encoded by the Cluster F1 mycobacteriophage NormanBulbieJr

Bethany M. Wise, Kaylia Edwards, Cole R. Jirsa, Sabrina Abbruzzese et autres

Abstract NormanBulbieJr (NBJ) is a temperate siphovirus isolated on the host Mycobacterium smegmatis mc 2 155 that encodes 102 gene products, 60 of which have no known function (NKF). Based on gene content, NBJ is classified as a Cluster F, Subcluster F1 …

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An inclusive Research and Education Community (iREC) model to facilitate undergraduate science education reform

Denise L. Monti, Julia C. Gill, Tamarah L. Adair, Sandra D. Adams et autres

Over the last two decades, there have been numerous initiatives to improve undergraduate student outcomes in STEM. One model for scalable reform is the inclusive Research Education Community (iREC). In an iREC, STEM faculty from colleges and universities across the nation are …

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Models of classroom assessment for course-based research experiences

David I. Hanauer, Tong Zhang, Mark J Graham, Sandra D. Adams et autres

Course-based research pedagogy involves positioning students as contributors to authentic research projects as part of an engaging educational experience that promotes their learning and persistence in science. To develop a model for assessing and grading students engaged in this type of learning …

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Methods for generating and colonizing gnotobiotic zebrafish

John Franklin Rawls, Michelle Kanther, Linh N Pham, Ivana Semova

Vertebrates are colonized at birth by complex and dynamic communities of microorganisms that can contribute significantly to host health and disease. The ability to raise animals in the absence of microorganisms has been a powerful tool for elucidating the relationships between animal …

Commensal microbiota stimulate systemic neutrophil migration through induction of Serum amyloid A: Microbiota regulate systemic neutrophil function

Xiaolun Sun, Melinda R. Grosser, Edward J. Flynn, Michelle Kanther et autres

Neutrophils serve critical roles in inflammatory responses to infection and injury, and mechanisms governing their activity represent attractive targets for controlling inflammation. The commensal microbiota is known to regulate the activity of neutrophils and other leucocytes in the intestine, but the systemic …

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Host–microbe interactions in the developing zebrafish

Michelle Kanther, John Franklin Rawls

The amenability of the zebrafish to in vivo imaging and genetic analysis has fueled expanded use of this vertebrate model to investigate the molecular and cellular foundations of host-microbe relationships. Study of microbial encounters in zebrafish hosts has concentrated on developing embryonic …

Microbial Colonization Induces Dynamic Temporal and Spatial Patterns of NF-κB Activation in the Zebrafish Digestive Tract

Michel Bagnat, Xiaolun Sun, John Franklin Rawls, Lantz C. Mackey et autres

The nuclear factor κ-light-chain enhancer of activated B cells (NF-κB) transcription factor pathway is activated in response to diverse microbial stimuli to regulate expression of genes involved in immune responses and tissue homeostasis. However, the temporal and spatial activation of NF-κB in …

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Patterns and Scales in Gastrointestinal Microbial Ecology

Ivana Semova, Michelle Kanther, J. Gray Camp, John Franklin Rawls

The body surfaces of humans and other animals are colonized at birth by microorganisms. The majority of microbial residents on the human body exist within gastrointestinal (GI) tract communities, where they contribute to many aspects of host biology and pathobiology. Recent technological …

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Initiation and early growth of the skull vault in zebrafish

Michelle Kanther, Alexandra Scalici, Azman Rashid, Kelly Miao et autres

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Sa1764 Commensal Microbiota Stimulate Systemic Neutrophil Migration Through Induction of Serum Amyloid A

Sarah Tomkovich, Michelle Kanther, Xiaolun Sun, Melinda R. Grosser et autres

Commensal microbiota stimulate systemic neutrophil migration through induction of Serum amyloid A

Michelle Kanther, Sarah Tomkovich, Xiaolun Sun, Melinda R. Grosser et autres

Neutrophils serve critical roles in inflammatory responses to infection and injury, and mechanisms governing their activity represent attractive targets for controlling inflammation. The commensal microbiota is known to regulate the activity of neutrophils and other leucocytes in the intestine, but the systemic …

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Microbial Colonization Induces Dynamic Temporal and Spatial Patterns of NF-κB Activation in the Zebrafish Digestive Tract

Michelle Kanther, Xiaolun Sun, Marcus Mühlbauer, Lantz C. Mackey et autres

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