Jessica Huyet

Structural basis for substrate selectivity and nucleophilic substitution mechanisms in human adenine phosphoribosyltransferase catalyzed reaction

Mohammad Ozeir, Jessica Huyet, Marie‐Claude Burgevin, Benoı̂t Pinson et autres

The reversible adenine phosphoribosyltransferase enzyme (APRT) is essential for purine homeostasis in prokaryotes and eukaryotes. In humans, APRT (hAPRT) is the only enzyme known to produce AMP in cells from dietary adenine. APRT can also process adenine analogs, which are involved in …

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Crystal Structure of Human APRT wild type in complex with Phosphate ion.

P. Nioche, Jessica Huyet, Mohammad Ozeir

Structural Insights into the Forward and Reverse Enzymatic Reactions in Human Adenine Phosphoribosyltransferase

Jessica Huyet, Mohammad Ozeir, Marie‐Claude Burgevin, Benoı̂t Pinson et autres

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Crystal Structure of Human APRT-Tyr105Phe variant in complex with Adenine, PRPP and Mg2+, 14 days post crystallization (with AMP and PPi products partially generated)

P. Nioche, Jessica Huyet, Mohammad Ozeir

Crystal Structure of Human APRT wild type in complex with AMP

Pierre Nioche, Jessica Huyet, Mohammad Ozeir

Crystal Structure of Human APRT wild type in complex with PRPP and Mg2+

P. Nioche, Jessica Huyet, Mohammad Ozeir

Structural relationships between small β-pore-forming toxins from Clostridium perfringens

Ajit K. Basak, Claire E. Naylor, Jessica Huyet, Christos G. Savva et autres

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Clostridium perfringens α-toxin interaction with red cells and model membranes

Sharon A. Jewell, Richard W. Titball, Jessica Huyet, Claire E. Naylor et autres

The effects of Clostridium perfringensα-toxin on host cells have previously been studied extensively but the biophysical processes associated with toxicity are poorly understood. The work reported here shows that the initial interaction between the toxin and lipid membrane leads to measurable changes …

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List of Contributors

Klaus Aktories, Alberto Alape‐Girón, Julien Barbier, Joseph T. Barbieri et autres

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Structural Insights into Clostridium perfringens Delta Toxin Pore Formation

Jessica Huyet, Claire E. Naylor, Christos G. Savva, Maryse Gibert et autres

Clostridium perfringens Delta toxin is one of the three hemolysin-like proteins produced by C. perfringens type C and possibly type B strains. One of the others, NetB, has been shown to be the major cause of Avian Nectrotic Enteritis, which following the …

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Listeria monocytogenes Antigen B

Jessica Huyet, Claire E. Naylor, S. Geddes, Asim Kumar Basak

Crystal structure ofClostridium perfringensDelta toxin and a model of its pore-form

Jessica Huyet, Claire E. Naylor, Michel Gilbert, Michel Robert Popoff et autres

Poster Sessions C470A thermostable organic-solvent-tolerant Lipase 42 (L42) was successfully crystallized under the condition of 0.1M MES monohydrate, 0.1M NaH 2 PO 4 , 0.1M KH 2 PO 4 and 2.0M NaCl using counter-diffusion and sitting-drop vapor diffusion technique.Remarkably after data processing, …

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