Andrew G. Allmon

Health Outcomes, Healthcare Resource Use, and Economic Burden of Invasive Meningococcal Disease in the United States Among Children Aged <11 Years

Oscar Herrera-Restrepo, Elizabeth Packnett, Megan Richards, Elise J. Kuylen et autres

Although uncommon, invasive meningococcal disease (IMD) is a serious and life-threatening illness. In the United States (US), incidence is highest among infants aged <1 year, but research characterizing pediatric IMD burden is limited. This study aimed to evaluate health outcomes and economic …

us, be (code pays fourni par la source)

Incidence of RSV-Acute Respiratory Infection in Adults 18–64 Years With High-Risk Conditions: A Prospective Community-based Surveillance Study

Wendelyn Bosch, Katherine S. King, Chung‐Il Wi, DAVID A. WATSON et autres

Background: Data on respiratory syncytial virus (RSV) acute respiratory infection (ARI) among community-dwelling U.S. adults aged 18 to 64 years, particularly those with high-risk conditions (HRC), remain limited. This study estimated incidence and attack rates of RSV-ARI and RSV lower respiratory tract …

us (code pays fourni par la source)

Real-world Effectiveness of Adjuvanted RSVPreF3 Vaccine in Preventing RSV-associated Lower Respiratory Tract Disease Hospitalization in Adults ≥60 Years of Age: Early Results From a Test-negative Design Analysis

Jennifer H Ku, Lei Qian, Lina S. Sy, Bradley K. Ackerson et autres

In a test-negative design, we estimated within-season vaccine effectiveness (VE) of adjuvanted RSVPreF3 against laboratory-confirmed respiratory syncytial virus (RSV)-lower respiratory tract disease-associated hospitalizations in adults ≥60 years during Dec2023-Feb2025. Results showed 82.3% overall VE and 81.0%-92.1% VE across subgroups, including those at …

us, be (code pays fourni par la source)

Risk of Invasive Meningococcal Disease in Children Aged <11 Years in the United States

Oscar Herrera-Restrepo, Elizabeth Packnett, Megan Richards, Elise J. Kuylen et autres

Background: Invasive meningococcal disease (IMD) is associated with high case-fatality rates and severe long-term sequelae. In the United States (US), IMD incidence rate (IR) is highest among infants aged <1 year, with most cases occurring in infants aged <6 months. This study …

us, be (code pays fourni par la source)

P-1490. Health Outcomes and Economic Burden in Commercially- and Medicaid-Insured Infants Diagnosed with Invasive Meningococcal Disease in the United States

Oscar Herrera-Restrepo, Elizabeth Packnett, Megan Richards, Elise J. Kuylen et autres

Abstract Background While uncommon, invasive meningococcal disease (IMD) is severe and progresses rapidly. In the United States (US), the highest IMD incidence rates are reported among infants. In this study, we describe health outcomes and economic burden among US infants (< 1 …

us (code pays fourni par la source)

P-1491. Invasive Meningococcal Disease Incidence and Risk Among Commercially- and Medicaid-Insured Infants in the United States

Oscar Herrera-Restrepo, Elizabeth Packnett, Megan Richards, Elise J. Kuylen et autres

Abstract Background Invasive meningococcal disease (IMD), caused by Neisseria meningitidis, is an uncommon but serious disease. The highest incidence rates (IRs) in the United States (US) are reported among infants (< 1 year). In this study, we estimated IMD IRs by patient …

us (code pays fourni par la source)

The relationship between socio-economic inequity indicators and 4CMenB vaccination rates in infants and adolescents in Spain: An ecological correlation study

Georgios Nikitas, Laura Alexandra Grandet Vallejo, Andrew G. Allmon, Jennifer G. Gaultney et autres

Invasive meningococcal disease (IMD) is associated with a high mortality rate and can cause severe long-term sequelae. In Spain, the majority of IMD cases are caused by serogroup B. The four-component meningococcal serogroup B vaccine (4CMenB) is included in the Spanish infant …

be, es, us, gb (code pays fourni par la source)

Impact of asthma status on the risk of respiratory syncytial virus acute respiratory infection

Young J. Juhn, Thanai Pongdee, Katherine S. King, Wendelyn Bosch et autres

Background: Respiratory syncytial virus acute respiratory infections (RSV-ARI) cause substantial morbidity to children, older adults, and adults with certain chronic conditions. The impact of asthma on risk of RSV-ARI in non-elderly adults (<65 yo) is unclear. Objective: To assess the impact of …

us, be (code pays fourni par la source)

EE80 Healthcare Resource Use in Commercially- and Medicaid-Insured Infants, Toddlers, and Children Diagnosed With Invasive Meningococcal Disease in the United States

Oscar Herrera-Restrepo, Elizabeth Packnett, Megan Richards, Elise J. Kuylen et autres

us, be (code pays fourni par la source)

Comparing PCSK9 Monoclonal Antibody Treatment Strategies Following Myocardial Infarction Using Negative Control Outcomes: A Target Trial Emulation Study

Rosa Sloot, Alexander Breskin, Lisandro Damián Colantonio, Andrew G. Allmon et autres

BACKGROUND: Initiation of proprotein convertase subtilisin/kexin type 9 monoclonal antibody (PCSK9 mAb) for lipid-lowering following myocardial infarction (MI) is likely affected by patients' prognostic factors, potentially leading to bias when comparing real-world treatment effects. METHODS: Using target-trial emulation, we assessed potential confounding …

gb, us, tw, rs (code pays fourni par la source)

USE OF NEGATIVE CONTROL OUTCOMES TO ASSESS THE COMPARABILITY OF PCSK9I MAB TREATMENT PROTOCOLS FOLLOWING MYOCARDIAL INFARCTION

Alexander Breskin, Rosa Sloot, Ying Yu, Andrew G. Allmon et autres

us (code pays fourni par la source)

A Randomized Trial of Point-of-Care Early Infant Human Immunodeficiency Virus (HIV) Diagnosis in Zambia

Carla J. Chibwesha, Katie R. Mollan, Catherine E. Ford, Aaron Lunda Shibemba et autres

BACKGROUND: Point-of-care (POC) early infant diagnosis (EID) provides same-day results and the potential for immediate initiation of antiretroviral therapy (ART). METHODS: We conducted a pragmatic trial at 6 public clinics in Zambia. HIV-exposed infants were individually randomized to either (1) POC EID …

us, Zambie (code pays fourni par la source)