Tatiana P. Ugarova

TARGETING THE CAPSULE OF KLEBSIELLA PNEUMONIAE WITH A CATIONIC CR3-BINDING PROTEIN ENHANCES PHAGOCYTOSIS AND PROMOTES BACTERIAL CLEARANCE AND SURVIVAL IN A MOUSE SEPSIS MODEL

Nataly Podolnikova, Iryna Klymenko, James Alagna, Cyrus Diercksmeier et autres

ABSTRACT Platelet Factor 4 (PF4), a cationic antimicrobial peptide, serves as a ligand for the myeloid-specific phagocytic receptor CR3 (Mac-1, CD11b/CD18). We previously demonstrated that recombinant dimeric PF4 (rdPF4) functions as a bacterial opsonin, enhancing phagocytosis of Gram-positive Staphylococcus aureus and facilitating …

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Structural instability of the superficial layers of the fibrinogen matrix contributes to its nonadhesive properties

Valeryi K. Lishko, Aibek Mursalimov, Nataly P. Podolnikova, Tatiana P. Ugarova

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Refolding of the recombinant IgV domain of CD47 from E. coli for NMR studies

Shundene Key, E. Shannon Neeley, Nataly P. Podolnikova, Tatiana P. Ugarova et autres

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Control of Macrophage Fusion By Sensing the Physical Properties of Fibrin(ogen) Matrices

Nataly P. Podolnikova, Arnat Balabiyev, Woosuk S. Hur, Matthew J. Flick et autres

Macrophage fusion is a salient and unwanted characteristic of implanted biomaterials. We have recently shown that macrophage fusion requires fibrinogen, as fibrinogen-deficient mice do not support this process. We also found that this is not fibrinogen itself but rather its clotting product, …

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αMI-domain of integrin Mac-1 binds the cytokine pleiotrophin using multiple mechanisms

Hoa Nguyen, Nataly P. Podolnikova, Tatiana P. Ugarova, Xu Wang

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Abstract 2187 PLEIOTROPHIN'S INTERACTION WITH αM-I DOMAIN OF INTEGRIN αMβ2 IS ACTIVATION STATE DEPENDENT

Hoa Nguyen, Tatiana P. Ugarova, Nataly P. Podolnikova, Xu Wang

Taken together, our data support a mechanism where the regulatory loop and inhibitory phosphorylation of the loop reduce the affinity of eEF-2K for CaM, potentially explaining how eEF-2K activity is suppressed under normal cellular conditions.Our data also reveals that activation of the …

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α M I-domain of Integrin Mac-1 Binds the Cytokine Pleiotrophin Using Multiple Mechanisms

Hoa Phuoc Trung Nguyen, Nataly P. Podolnikova, Tatiana P. Ugarova, Xu Wang

SUMMARY The integrin Mac-1 (α M β 2 , CD11b/CD18, CR3) is an important adhesion receptor expressed on macrophages and neutrophils. Mac-1 is also the most promiscuous member of the integrin family that binds a diverse set of ligands through its α …

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Pleiotrophin’s interaction with αMI domain of integrin αMβ2 is activation state dependent

Hoa Phuoc Trung Nguyen, Xu Wang, Tatiana P. Ugarova, Nataly P. Podolnikova

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Platelet factor 4 improves survival in a murine model of antibiotic-susceptible and methicillin-resistant Staphylococcus aureus peritonitis

Nataly P. Podolnikova, Valeryi K. Lishko, Robert W. Roberson, Zhiqian Koh et autres

The complement receptor CR3, also known as integrin Mac-1 (CD11b/CD18), is one of the major phagocytic receptors on the surface of neutrophils and macrophages. We previously demonstrated that in its protein ligands, Mac-1 binds sequences enriched in basic and hydrophobic residues and …

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Platelet Factor 4 (PF4) Improves Survival in a Murine Model of Antibiotic-Susceptible and Methicillin-Resistant Staphylococcus Aureus Peritonitis

Nataly P. Podolnikova, Valeryi K. Lishko, Robert W. Roberson, Zhqian Koh et autres

ABSTRACT The complement receptor CR3, also known as integrin Mac-1 (CD11b/CD18), is one of the major phagocytic receptors on the surface of neutrophils and macrophages. We previously demonstrated that in its protein ligands, Mac-1 binds sequences enriched in basic and hydrophobic residues …

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The CIS association of CD47 with integrin Mac-1 regulates macrophage responses by stabilizing the extended integrin conformation

Nataly P. Podolnikova, Shundene Key, Xu Wang, Tatiana P. Ugarova

CD47 is a ubiquitously expressed cell surface integrin-associated protein. Recently, we have demonstrated that integrin Mac-1 (α M β 2 , CD11b/CD18, CR3), the major adhesion receptor on the surface of myeloid cells, can be coprecipitated with CD47. However, the molecular basis …

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THE ASSOCIATION OF CD47 WITH INTEGRIN Mac-1 REGULATES MACROPHAGE RESPONSES BY STABILIZING THE EXTENDED INTEGRIN CONFORMATION

Nataly P. Podolnikova, Shundene Key, Xu Wang, Tatiana P. Ugarova

ABSTRACT CD47 is a ubiquitously expressed cell surface integrin-associated protein. Recently, we have demonstrated that integrin Mac-1 (α M β 2 , CD11b/CD18, CR3), the major adhesion receptor on the surface of myeloid cells, can be coprecipitated with CD47. However, the molecular …

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