Susanne Braun

PET/CT-guided management of immune checkpoint blockade and multi-modal profiling following treatment in long-term responders with metastatic lung cancer in the National Network Genomic Medicine Lung Cancer Germany (nNGM)

N. Frost, Maria Joosten, Jannik Franzen, Marcel Wiesweg et autres

BACKGROUND: The optimal duration of immune checkpoint blockade (ICB) in lung cancer remains undefined. Indefinite treatment in long-term responders increases health care burden, exposes patients to avoidable toxicities, and is not supported by any clinical or biological rationale or translational data. Prospective …

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Resistance to HER2 targeted therapy in early breast cancer (EBC): The clinical management of intratumoral heterogeneity (ITH) in HER2 overexpressing EBC

Athanasios Argyriadis, Konstantinos Kalfoutzos, Silvia Khodaverdi, Susanne Braun et autres

Introduction A case report presenting the diagnostic and therapeutic challenges of ITH in EBC, highlighting the need for multilayer testing to allow appropriate treatment. Methodology A 49-year-old female presented with cT 2 N 0 EBC confined to the left breast. The core …

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Tumor cell identification and classification in esophageal adenocarcinoma specimens by hyperspectral imaging

Marianne Maktabi, Yannis Wichmann, H. Köhler, Henning Ahle et autres

Esophageal cancer is the sixth leading cause of cancer-related death worldwide. Histopathological confirmation is a key step in tumor diagnosis. Therefore, simplification in decision-making by discrimination between malignant and non-malignant cells of histological specimens can be provided by combination of new imaging …

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Mastering Eventual Consistency

Susanne Braun

The quality requirements of modern systems – such as data-intensive systems – call for the design of distributed systems, facilitation of asynchronous processing, and, correspondingly, eventual consistency. In consequence, consistency of application data is no longer achieved with serializability – a technique …

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Abstract P2-12-03: Phenotype shifting in early breast cancer with and without primary systemic treatment: A retrospective cohort analysis correlating core needle biopsies and excisional biopsies in 1250 consecutive real-world cases

Athanasios Argyriadis, Michael Bange, Keyur M. Mehta, Sibylle Loibl et autres

Abstract Introduction: Breast cancer (BC) is a heterogenous disease, composed of various subclones with different response to treatment strategies, known as clonal sensitivity. PST might modulate the biology of BC cells and thus, the molecular subtype. In our single-center, retrospective cohort analysis …

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Tackling Consistency-related Design Challenges of Distributed Data-Intensive Systems

Susanne Braun, Stefan Deßloch, Eberhard Wolff, Frank Elberzhager et autres

Background: Distributed data-intensive systems are increasingly designed to be only eventually consistent. Persistent data is no longer processed with serialized and transactional access, exposing applications to a range of potential concurrency anomalies that need to be handled by the application itself. Controlling …

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Correlation between diagnostic core needle biopsies (CNB) and excisional biopsies (EB) in early breast cancer (EBC): a retrospective cohort analysis

Athanasios Argyriadis, Susanne Braun, K. Mehta, Silvia Khodaverdi et autres

Objektives A single-center, retrospective analysis evaluating the concordance of the molecular subtype, HR, HER2 status and Ki67 based on CNB and EB in primary EBC with and without primary systemic therapy (PST). Materials and methods The analysis was performed in two cohorts: …

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21P BACH1 and HIF1α predict response to neoadjuvant nab-paclitaxel (nP) treatment in early breast cancer (BC)

Valentina A. Vladimirova, Andreas Schneeweiß, Christian Jackisch, Karsten Ernst Weber et autres

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Advanced Domain-Driven Design for Consistency in Distributed Data-Intensive Systems

Susanne Braun, Annette Bieniusa, Frank Elberzhager

More and more data-intensive systems have emerged lately. Big Data, Artificial Intelligence, or cloud-native applications all require high scalability and availability. Data is no longer persisted in one central relational database with serialized and transactional access, but rather distributed and replicated among …

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Replication Package for "Tackling Consistency-related Design Challenges of DistributedData-Intensive Systems – An Action Research Study"

Susanne Braun

This is a replication package for the action research study reported in the paper “Tackling Consistency-related Design Challenges of Distributed Data-Intensive Systems – An Action Research Study” accepted at ESEM 2021: https://doi.org/10.1145/3475716.3475771. In the course of the action research study an initial …

Replication Package for "Tackling Consistency-related Design Challenges of DistributedData-Intensive Systems – An Action Research Study"

Susanne Braun

This is a replication package for the action research study reported in the paper “Tackling Consistency-related Design Challenges of Distributed Data-Intensive Systems – An Action Research Study” accepted at ESEM 2021: https://doi.org/10.1145/3475716.3475771. In the course of the action research study an initial …

Insights collaboration space

Susanne Braun, Marcus Trapp, Claudia Nass, Matthias Gerbershagen et autres

Next to technical expertise, the ability to effectively communicate and collaborate with a large number of different stakeholders with varying technical backgrounds has always been one of the vital skills of good software architects. So far, software architects have had to mainly …

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