Ashaimaa Y. Moussa

Comparative Metabolic Profiling and Anti‐Inflammatory Evaluation of Ceiba speciosa and Ceiba insignis Flower Extracts

Kholoud Kh. Kadry, Ashaimaa Y. Moussa, Fadia S. Youssef, Manal S. Afifi

Ceiba insignis and Ceiba speciosa are utilized in traditional medicine for treating inflammatory diseases. The analysis of their extracts by LC-ESI-MS/MS revealed the presence of flavonoids like kaempferol hexoside and apigenin-O-deoxyhexosyl hexoside and fatty acids, namely, sterculic acid, α-linolenic acid, and dihydrosterculic …

Égypte (code pays fourni par la source)

Chemical profiling, molecular docking, and harnessing Manuka honey's antimicrobial and prebiotic potential in probiotic milk and yoghurt

Nehal Ibrahim, Ashaimaa Y. Moussa, Eman M. Taher, Jinhai Luo et autres

Égypte, cn, hk (code pays fourni par la source)

Discovery of a Fungal HR-PKS Cluster Encoding Biosynthetic Pathways for Macrolides with Two Distinct Ring Sizes

Yi Jie Li, Yohei Morishita, Akihiro Sugawara, Ashaimaa Y. Moussa et autres

Through the heterologous expression of a highly reducing polyketide synthase and a thioesterase from the apeml cluster, a putative macrolide biosynthetic gene cluster on the genome of Aspergillus petrakii, we obtained a naturally new 10-membered macrolide (1) and recifeiolide (2), a known …

jp, Égypte (code pays fourni par la source)

Nutraceuticals: Plant-Based Nutrition for Health and Wellness

Salma Sameh, Ashaimaa Y. Moussa, Nada M. Mostafa, Abdel Nasser B. Singab

Biosynthesis of Circumdatins Employs an Anthranilate Tailoring Pathway for NRPS Substrate Supplies

Yohei Morishita, Yuto Homma, Akihiro Sugawara, Ashaimaa Y. Moussa et autres

Circumdatins are a unique class of fungal alkaloids featuring a pyrrolo[4,2]benzodiazepine scaffold. In this study, we identified the biosynthetic gene cluster through genome mining guided by structural analysis and docking simulations. Heterologous expression and precursor feeding experiments revealed an unprecedented tailoring pathway …

jp, Égypte, nz, no (code pays fourni par la source)

AMP-Activated Protein Kinase mediates the anti-inflammatory and antioxidant effects of Ceiba speciosa and Ceiba insignis in a rat model of ulcerative colitis

Kholoud Kh Kadry, Marwa M. Nagib, Ashaimaa Y. Moussa, Fadia S. Youssef et autres

Égypte (code pays fourni par la source)

Role of Saponins from Platycodon grandiflorum in Alzheimer’s Disease: DFT, Molecular Docking, and Simulation Studies in Key Enzymes

Ashaimaa Y. Moussa, Abdullah R. Alanzi, Jinhai Luo, Wai San Cheang et autres

Alzheimer’s disease (AD), one of the neurodegenerative disorders, afflicts negatively across the whole world. Due to its complex etiology, no available treatments are disease-altering. This study aimed to explore isolated saponins profiles from Platycodon grandiflorum in the binding pockets of six target …

Égypte, sa, hk, mo (code pays fourni par la source)

Integration of pharmacophore-based virtual screening, molecular docking, ADMET analysis, and MD simulation for targeting EGFR: A comprehensive drug discovery study using commercial databases

Abdullah R. Alanzi, Ashaimaa Y. Moussa, Mohammed S. Alsalhi, Tayyab Nawaz et autres

The epidermal growth factor receptor (EGFR), a crucial component of cellular signaling pathways, is frequently dysregulated in a range of cancers. EGFR targeting has become a viable approach in the development of anti-cancer medications. This study employs an integrated approach to drug …

sa, Égypte, us, kw (code pays fourni par la source)

Unveiling the molecular mechanisms of adzuki bean (Vigna angularis) derived bioactive phytochemicals in combating obesity

Jinhai Luo, Yingzi Wu, Ashaimaa Y. Moussa, Yanyi Huang et autres

cn, Égypte, au, fr (code pays fourni par la source)

The Underrepresented Quinolinone Alkaloids in Genera Penicillium and Aspergillus: Structure, Biology, and Biosynthetic Machinery

Ashaimaa Y. Moussa, Muhammad A. K. Albelbisy, Abdel Nasser B. Singab

Quinolone alkaloids are N-heterocycles with extensive structural diversity, mainly derived from in fungi from anthranilic acid and amino acids as precursors with a wide range of biological activities as antifungal, antimicrobial, anti-inflammatory, and insecticidal activities. The quinolone basic skeleton comprised of either …

Égypte (code pays fourni par la source)

Insights into Chemical Diversity and Potential Health-Promoting Effects of Ferns

Ashaimaa Y. Moussa, Jinhai Luo, Baojun Xu

The scientific community is focusing on how to enhance human health and immunity through functional foods, and dietary supplements are proven to have a positive as well as a protective effect against infectious and chronic diseases. Ferns act as a taxonomical linkage …

Égypte, cn (code pays fourni par la source)

Green preparation and evaluation of the anti‐psoriatic activity of vesicular elastic nanocarriers of kojic acid from Aspergillus oryzae N12: Repurposing of a dermo‐cosmetic lead

Ashaimaa Y. Moussa, Haidy Abbas, Mariam Zewail, Passent M.E. Gaafar et autres

Psoriasis is a skin disorder characterized by impaired epidermal differentiation that is regularly treated by systemic drugs with undesirable side effects. Based on its anti-inflammatory, antiproliferative and anti-melanoma attributes, the fungal metabolite kojic acid represents an attractive candidate for anti-psoriatic research. The …

Égypte (code pays fourni par la source)