Fabiane Carvalho de Macedo

Co-occurrence of low-grade fibromyxoid sarcoma and familial Tatton-Brown-Rahman syndrome with germline DNMT3A c.1904G > A (p.Arg635Gln): a case report

Luana Diniz Guerra Braz, Renan Gomes, Fabiane Carvalho de Macedo, Gabriel Lanes Cypriano et autres

BACKGROUND: Tatton‑Brown‑Rahman syndrome (TBRS) is an ultra-rare overgrowth and neurodevelopmental disorder caused by germline DNMT3A variants. Neoplastic manifestations are rarely reported; consequently, data regarding tumor susceptibility in this condition remain limited. Low-grade fibromyxoid sarcoma (LGFMS) has not been previously reported in individuals …

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Response to the letter to the editor: Appraisal of suspicious for malignancy cytology: nuclear characteristics deserve special attention in reported cytology analysis – real-world scenario cohort in thyroidology

Fabiane Carvalho de Macedo, Ricardo Luiz Costantin Delfim, Fernanda Vaisman

Dear Editor, We thank Dr Ilker Sengul and Dr Demet Sengul for their thoughtful and insightful comments () on our recently published manuscript, “In suspicious for malignancy thyroid nodule aspirates, nuclei characteristics deserve special attention in reported cytology analysis – real world …

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P099: Novel association of soft tissue sarcoma with Tatton-Brown-Rahman syndrome: A case report

Luana Braz, Renan Gabriel Gomes, Fabiane Carvalho de Macedo, Anna Cláudia Evangelista dos Santos

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COMPARAÇÃO ENTRE CITOLOGIA ANAL E BIÓPSIA DIRIGIDA POR ANUSCOPIA DE ALTA RESOLUÇÃO (HRA) NO DIAGNÓSTICO DE LESÕES INTRAEPITELIAIS ESCAMOSAS DE ALTO GRAU EM MULHERES VIVENDO COM HIV (WLWHIV) NA REGIÃO METROPOLITANA DO RIO DE JANEIRO

Raphaela dos Santos Lima, Mario Gustavo de Aranda Pacheco, Rafael Martins Lameira, Maria Midori Miura Piragibe et autres

Autor correspondente: RAFAEL MARTINS LAMEIRA - rafaelmlameira@gmail.com Introdução O câncer anal é uma neoplasia rara, mas sua taxa é mais elevada em grupos específicos, como mulheres vivendo com HIV (WLWHIV). Fatores de risco como infecção persistente pelo papilomavírus humano (HPV) e histórico …

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Unveiling the Landscape of PD-L1 Expression and Tumor-Infiltrating Lymphocyte Subtypes in Advanced Triple-Negative Breast Cancer in Brazil

Alexssandra Lima Siqueira dos Santos, Jessé Lopes da Silva, Lucas Zanetti de Albuquerque, Antônio Lucas Araújo Neto et autres

Purpose: This study aimed to assess the frequency and prognostic significance of programmed cell death ligand 1 (PD-L1) expression and tumor-infiltrating lymphocyte (TIL) subtypes in advanced triple-negative breast cancer (TNBC). Patients and Methods: A database search was conducted to identify women with …

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In suspicious for malignancy thyroid nodule aspirates, nuclei characteristics deserves special attention in reported cytology analysis – real world scenario cohort

Fabiane Carvalho de Macedo, Ricardo Luiz Costantin Delfim, Fernanda Vaisman

OBJECTIVE: To identify cytologic characteristics in a suspicious for malignancy cohort that may help to recognize false positives in cytopathological tests of thyroid nodules in a "real world scenario", with histopathological reports as the gold standard. METHODS: Cytomorphologic features of suspicious for …

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Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome

Gabriela Rapozo Guimarães, Giovanna Resk Maklouf, Cristiane Esteves Teixeira, Leandro de Oliveira Santos et autres

Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and treatment responses due to their remarkable plasticity and tumorigenic behaviors. Here, we integrate single-cell RNA-sequencing data from different cancer types, identifying 29 MDC subpopulations within the tumor microenvironment. Our analysis reveals abnormally expanded …

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Non-Hodgkin's Anaplastic Large T-Cell Lymphoma: A Case Report

Gabriele Alves Halpern, Luiza Miziara Brochi, Cintia Gomes, Gabriela Lachter Zusman et autres

Anaplastic large T/null cell lymphoma (ALCL) is an aggressive non-Hodgkin's lymphoma (NHL) that most commonly affects young men. Herein, we present a case of a 32-year-old male patient in severe condition with ulcerated right axillary adenopathy, diffuse subcutaneous nodules, and sepsis. He …

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Identification of novel myeloid-derived cell states with implication in cancer outcome

Gabriela Rapozo Guimarães, Giovanna Resk Maklouf, Cristiane Esteves Teixeira, Leandro de Oliveira Santos et autres

Abstract Tumor-associated myeloid-derived cells (MDCs) significantly impact cancer prognosis and treatment response due to their remarkable plasticity and tumorigenic behaviors. We integrated single-cell RNA-Sequencing datasets from seven different cancers, resulting in a comprehensive collection of 29 MDC subpopulations in the tumor microenvironment …

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Pulmonary metastasis of osteosarcoma: multiple presentations in a single patient

Jéssica Albuquerque Marques Silva, Edson dos Santos Marchiori, Fabiane Carvalho de Macedo, Paulo Ricardo Garcia da Silva et autres

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Dermoscopic features of clear cell acanthoma

Daniela Gomes Cunha, Luiza Erthal de Britto Pereira Kassuga-Roisman, Luisa Kelmer Côrtes de Barros Silveira, Fabiane Carvalho de Macedo

Clear cell acanthoma is an uncommon type of benign epithelial tumor. Typically, it is a solitary lesion found on the lower limbs. It presents as a nodule or small plaque with slow and well-defined growth. Diagnosis used to be clinical and histopathological, …

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A cross-sectional study examining the expression of splice variants K-RAS4A and K-RAS4B in advanced non-small-cell lung cancer patients

Veronica Aran, Pedro Masson Domingues, Fabiane Carvalho de Macedo, Tatiane Caldas Montella et autres

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