Lucas Zanetti de Albuquerque

Social determinants and regional disparities in place of death among breast cancer decedents in Brazil: a 25-year population-based analysis

Jessé Lopes da Silva, Lívia Costa de Oliveira, Lucas Zanetti de Albuquerque, Pedro Henrique Araújo de Souza et autres

Place of death is a population-level indicator of end-of-life care pathways and health system organization, but its interpretation depends on service availability, care coordination, and patient preferences. In resource-constrained settings, deaths outside healthcare facilities may reflect structural barriers, although mortality records cannot …

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Ovarian cancer global trends and disparities across 204 countries and territories

Luís Felipe Leite, Lucas Diniz da Conceição, Luiz Felipe Costa de Almeida, Lucas Zanetti de Albuquerque et autres

Introduction Ovarian cancer remains the deadliest gynecological malignancy and is frequently diagnosed at advanced stages. Updated global assessments are needed to quantify recent trends, forecast future disease burden, and characterize geographic disparities in outcomes. Methods We analyzed Global Burden of Disease 2023 …

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Social inequities and clinical outcomes in young women with cervical cancer: Real-world evidence

Luiza Cupertino Bérgomi, Giselle de Souza Carvalho, Lucas Zanetti de Albuquerque, Daniel Gonçalves Kischinhevsky et autres

OBJECTIVE: To assess the influence of social inequities and clinicopathological factors on survival outcomes in young women with cervical cancer treated at a comprehensive public cancer center in Brazil. METHODS: This retrospective analysis reviewed the medical records of women aged 18-39 diagnosed …

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Abstract PS4-12-05: Real-world evidence of ethnic-racial disparities in tumor-infiltrating lymphocytes and survival outcomes in early-stage triple-negative breast cancer

J. da Silva, Lucas Zanetti de Albuquerque, Fabiana Passos Rodrigues, Guilherme Gomes de Mesquita et autres

Abstract Background: Triple-negative breast cancer (TNBC), comprising 10-15% of all breast cancer cases, is characterized by an aggressive course and high early recurrence rates. Neoadjuvant chemotherapy (NACT), with the recent addition of pembrolizumab, stands as the standard treatment for early-stage TNBC, where …

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Abstract PS4-12-13: Real-world comparison of tumor-infiltrating lymphocytes and survival in advanced triple-negative breast cancer across racial groups in brazil

J. da Silva, A. dos Santos, Lucas Zanetti de Albuquerque, Antônio Lucas Araújo Neto et autres

Abstract Background: TNBC is an aggressive breast cancer subtype affecting younger, non-white women in Brazil, associated with higher recurrence and lower survival. Although chemotherapy remains the primary treatment for advanced TNBC, recent advances in immunotherapy highlight the importance of immune biomarkers such …

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Real-world insights into the prevalence and prognostic significance of trophoblast cell-surface antigen 2 and folate receptor alpha in uterine carcinosarcoma

Lucas Zanetti de Albuquerque, Jessé Lopes da Silva, Fabiana Resende Rodrigues, Priscila Valverde Fernandes et autres

BACKGROUND: Uterine carcinosarcomas (UCS) are rare and aggressive gynecological tumors and the description of biomarkers that can help guide targeted treatments in this disease is a critical gap in current medical research. This study aims to measure the prevalence of trophoblast cell-surface …

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Evaluating the Efficacy and Safety of NEOadjuvant CHEmoimmunotherapy in Early ER-Low/HER2-Negative Breast Cancer (NEOCHEER): A Systematic Review and Meta-Analysis

Jessé Lopes da Silva, Luís Felipe Leite, Wallace Klein Schwengber, Lucas Zanetti de Albuquerque et autres

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Abstract P5-02-10: Factors and Trends in Place of Death Among Breast Cancer Patients: A Population-Based Study in Brazil

Jessé Lopes da Silva, Natália Cristina Cardoso Nunes, Lívia Costa de Oliveira, Lucas Zanetti de Albuquerque et autres

Abstract Background: The quality of death serves as an indicator of the quality of care, shaped by factors such as the place of death, access to palliative care, and symptom management. In the context of Brazil, a diverse landscape with regional social …

Abstract P5-04-10: Age at Breast Cancer Diagnosis and Associated Demographic Factors: An Epidemiological Study in Brazil

Jessé Lopes da Silva, Natália Cristina Cardoso Nunes, Lucas Zanetti de Albuquerque, Pedro Henrique Souza et autres

Abstract Background: In recent years, shifts in the median age at breast cancer (BC) diagnosis have been observed in various countries. Multiple factors influence these changes, including demographic shifts, sex, lifestyle modifications, and genetic factors. As populations age and demographics change, there …

Abstract P1-09-02: Discordance in breast cancer pathology review and its impact on patient care

Lucas Zanetti de Albuquerque, Érica Tex Paulino, José Bines

Abstract Background: Routine external biopsy review by institutional pathologists is a practice implemented by many cancer centers. However, obtaining prompt and efficient central pathology review in low- and middle-income countries can be challenging. The delay in the review process can potentially hinder …

Sociodemographic and clinicopathological factors affecting survival in young women: Real-world data from Brazil.

Luiza Cupertino Bérgomi, Giselle de Souza Carvalho, Lucas Zanetti de Albuquerque, Daniel Kischinhevsky et autres

e17515 Background: Cervical cancer (CC) typically develops years after persistent HPV infection, yet its prevalence has been rising globally until recently, resulting in significant morbidity. This study sought to assess the influence of sociodemographic and clinicopathological factors on survival outcomes in young …

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Unveiling the Landscape of PD-L1 Expression and Tumor-Infiltrating Lymphocyte Subtypes in Advanced Triple-Negative Breast Cancer in Brazil

Alexssandra Lima Siqueira dos Santos, Jessé Lopes da Silva, Lucas Zanetti de Albuquerque, Antônio Lucas Araújo Neto et autres

Purpose: This study aimed to assess the frequency and prognostic significance of programmed cell death ligand 1 (PD-L1) expression and tumor-infiltrating lymphocyte (TIL) subtypes in advanced triple-negative breast cancer (TNBC). Patients and Methods: A database search was conducted to identify women with …

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