Joanne Parkes

Refining prognosis in advanced renal cell carcinoma: international real-world validation of the Meet-URO score in first-line immunotherapy combinations

Sara Elena Rebuzzi, Aruni Ghose, S. Rudman, Balaji Venugopal et autres

BACKGROUND: Effective risk stratification is essential for guiding treatment decisions in patients with metastatic renal cell carcinoma (mRCC). The Meet-URO score is a novel prognostic model that integrates the International Metastatic RCC Database Consortium (IMDC) criteria with neutrophil-to-lymphocyte ratio (NLR) and the …

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Prognostic performance of the Meet-URO Score compared with the IMDC score in metastatic renal cell carcinoma patients receiving first line immune-combinations

Aruni Ghose, Khin Sandar Tun, E. Johnston, Abdullah Sarwer et autres

Subcutaneous nivolumab: Advancing operational efficiency and patient-centred care in the NHS

Joanne Parkes

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Antibody Drug Conjugates in Urological Cancers: A Review of the Current Landscape

Aruni Ghose, Patricia Lapitan, Vedika Apte, Adheesh Ghosh et autres

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Post COVID availability of oncology drugs – Is this the new normal on both sides of the Atlantic?

Joanne Parkes, Vikash Dodhia, Stephen Ziter, Natasha Olson et autres

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The NHS SACT capacity crisis: Challenges and solutions

Vikash Dodhia, Joanne Parkes, Aruni Ghose, Wendy Ng

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CCDC 803590: Experimental Crystal Structure Determination

Neil Vasdev, Oleg Sadovski, Michael D. Moran, Joanne Parkes et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

Active conformation of rhodopsin is stabilized by phosphorylation

Joanne Parkes, Scott K. Gibson, Paul A. Liebman

Effect of photoregeneration on the calculation of the amount of rhodopsin bleached by small flashes

Joanne Parkes, Paul A. Liebman

A sample of rhodopsin that is exposed to a series of small light flashes of equal intensity is expected to bleach in successively smaller decrements in proportion to the remaining unbleached rhodopsin. The exponential depletion law describing this effect has been used …

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The effect of GDP on rod outer segment G-protein interactions.

Joseph Panico, Joanne Parkes, Paul A. Liebman

The role of GDP has heretofore been little studied in the analysis of visual receptor G-protein (G) interactions. Here we use kinetically resolved absorption and light scattering spectroscopy, centrifugation, porous membrane filtration, and enzyme assay to compare the effectiveness of GDP with …

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Mechanism of cGMP control in retinal rod outer segments

Paul A. Liebman, Ari Sitaramayya, Joanne Parkes, B. Buzdygon

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Progressive rod-cone degeneration in the dog: characterization of the visual pigment.

Joanne Parkes, Geoffrey K. Aguirre, J H Rockey, Paul A. Liebman

The visual pigment of dogs affected with progressive rod-cone degeneration was compared with that of normal dogs. Absorption spectra from detergent extracts and from intact photoreceptors showed no significant difference between normal and affected animals in the shape of the absorption spectrum, …