Geoffrey K. Aguirre

Cluster Analysis of Migraine-Associated Symptoms (CAMS) across the lifespan: a cross-sectional study

Carlyn Patterson Gentile, Eric A. Kaiser, Christina L. Szperka, Andrew D. Hershey et autres

BACKGROUND/PURPOSE: Headache-associated symptoms (e.g., sensory sensitivity, nausea) are used to classify primary headache disorders and define treatment outcomes. We developed Cluster Analysis of Migraine-Associated Symptoms (CAMS) to provide an aggregate measure that captures relationships between several headache-associated symptoms. CAMS reveals that a …

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Daily Light Exposure Habits of Youth with Migraine and the Association with Headache Frequency

Carlyn Patterson Gentile, Ryan Shah, Blanca Marquez de Prado, Nichelle Raj et autres

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Brain Parcellation and the Attribution of Normal Variation to Neurological Injury in Capital Trials

Elizabeth M. Siefert, Geoffrey K. Aguirre

Amplifying and ameliorating light avoidance in mice with photoreceptor targeting and calcitonin gene‐related peptide sensitization

Eric A. Kaiser, Audrey Cavanah, Geoffrey K. Aguirre, Frances E. Jensen

Abstract Objective The aim of this study was to determine the photoreceptor basis of light avoidance in mice and assess the effect of CGRP sensitization on this behavior. Background Prior studies have suggested that photophobia is mediated by a subset of retinal …

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Daily light exposure habits of youth with migraine: a prospective exploratory study

Carlyn Patterson Gentile, Ryan Shah, Blanca Marquez de Prado, Nichelle R. Raj et autres

Photophobia is a common symptom in youth with migraine, but it is unknown if this leads to light-avoidant behavior, and its effect on migraine disease burden. We conducted an exploratory study measuring light exposure using wearable light logger pendants in 20 adolescents …

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Associations Between Retinal Microvasculature, Orbital Blood Flow, and Cerebral Blood Flow in Healthy Adults

Qichao Wu, Sudipto Dolui, Manuel Taso, Hong Jiang et autres

Purpose: The purpose of this study was to assess whether retinal microvascular structures reflect orbital and cerebral perfusion in healthy adults across the lifespan. Methods: Arterial spin labeled (ASL) perfusion magnetic resonance imaging (MRI) and ocular coherence tomographic angiography (OCTA) data acquired …

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Headache-associated photophobia is more prevalent during winter: a cross-sectional study from a pediatric headache clinic

Carlyn Patterson Gentile, Geoffrey K. Aguirre, Andrew D. Hershey, Christina L. Szperka

Abstract Aim Sensitivity to light and noise is commonly associated with headache. It is unclear if exposure to more intense sensory environments, or exposure to more restricted sensory environments leading to intolerance, worsens sensory sensitivity more over time. We aimed to determine …

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Identifying chest-worn light logger adherence: a validation study

Carlyn Patterson Gentile, Ryan Shah, Blanca Marquez de Prado, Nichelle R. Raj et autres

Background: Light exposure plays an important role in overall health because it entrains circadian rhythms. Recent technological advances in wearable light loggers allow measurement daily light exposure habits. Using a chest-worn light logger, our goal was to 1) develop methodology for differentiating …

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Associations between retinal microvasculature, ocular blood flow, and cerebral blood flow in healthy adults

Qichao Wu, Sudipto Dolui, Jianhua Wang, Hong Jiang et autres

Motivation: Is retinal microvasculature a "window" to brain physiology? Goal(s): Test correlations between ocular blood flow, cerebral blood flow, and retinal microvasculature. Approach: We measured ocular blood flow (OBF) and cerebral blood flow (CBF) using arterial spin labeling (ASL) and retinal vessel …

A Neural Compass in the Human Brain during Naturalistic Virtual Navigation

Zhengang Lu, Joshua B. Julian, Geoffrey K. Aguirre, Russell A. Epstein

A central component of wayfinding is the ability to maintain a consistent representation of one's facing direction (FD) when moving about the world. In rodents, head direction cells are believed to support this "neural compass," but identifying a similar mechanism in humans …

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Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation

Raghavi Sudharsan, Natalia V. Dolgova, Jennifer Kwok, Alexa P. Gray et autres

BACKGROUND: Progressive photoreceptor loss in retinal degenerative diseases leads to irreversible vision impairment. Transplantation of human embryonic or induced pluripotent stem cell-derived photoreceptor precursor cells (PRPCs) offers potential for vision restoration. However, substantial early donor cell loss remains a major challenge. This …

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Design and calibration of a spectro-temporal light logger

Zachary J Kelly, Vincent Lau, Geoffrey K. Aguirre

Measurements of visual experience have largely focused upon spatial visual properties (e.g., orientation, spatial frequency) and have made use of static images and cinematic videos. To support studies of individual differences in visual experience, we created a personalized, wearable, all-day, high-speed light-logger. …

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