Torben Barington

CRISPR integration of an FLT3 CAR into the TRAC locus generates CAR T cells for AML

Maya Graham Noer, Kimmie B. Christensen, Nanna S. Mikkelsen, Sigrid Fu Skjelbostad et autres

Acute myeloid leukemia (AML) remains a therapeutically challenging hematological malignancy with high relapse rates, especially in patients harboring mutations in the FMS-like tyrosine kinase 3 ( FLT3 ) gene. FLT3, a receptor tyrosine kinase involved in hematopoietic cell proliferation and survival, is …

dk (code pays fourni par la source)

Evaluating the non-specific effects of BCG vaccination on the immune system and serological response to influenza vaccination in the elderly: A randomised controlled trial

Anne Marie Rosendahl Madsen, Frederik Schaltz‐Buchholzer, Ramona Trebbien, Rutger Jan Röring et autres

OBJECTIVES: The Bacillus Calmette-Guerin (BCG) vaccine has beneficial effects on the immune system, which may lead to non-specific protection against non-tuberculous infections and increase the response to subsequent vaccinations. Seasonal influenza vaccination is used to protect senior citizens against influenza, but the …

dk, Guinée-Bissau, nl (code pays fourni par la source)

Effect of BCG vaccination on the serological response to SARS-CoV-2 vaccination among Danish health care workers

Anne Marie Rosendahl Madsen, Lise Gehrt, Torben Barington, Morten Bjerregaard-Andersen et autres

dk, de, nl, us (code pays fourni par la source)

Case Report: Severe HHV-6-related encephalitis following anti-CD19 CAR-T therapy with no evidence of HHV-6 reactivation in transduced CAR-T cells

Nina Marie Birk, Katrine Kielsen, Özcan Met, Eva Kannik Haastrup et autres

We report a case of severe encephalitis caused by human herpes virus 6 (HHV-6) following CD19 chimeric antigen receptor T (CAR-T) cell therapy. Rapid expansion of circulating T-lymphocytes and high HHV-6 viral load (4,500,000 DNA copies/mL) early after CAR-T infusion suggested HHV-6 …

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OMIP‐115: High‐Dimensional Phenotypic Characterization of Human Natural Killer Cells for Therapeutic Use

Emil Birch Christensen, Moritz Schaefer, Mike Bogetofte Barnkob, Christian B. Nielsen et autres

This 29-color flow cytometry panel was developed and optimized for in-depth characterization of human peripheral blood NK cells for preclinical development and monitoring of NK cell therapies. The panel includes markers associated with NK cell differentiation, cytotoxicity, tissue residency, as well as …

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Role of NK Cells in Progression and Treatment of Multiple Myeloma

Iman Chanchiri, Emil Birch Christensen, Niels Abildgaard, Torben Barington et autres

Multiple myeloma (MM) is a haematological malignancy originating from terminally differentiated B cells, resulting in significant morbidity and mortality. Currently, MM is regarded as an incurable disease, often exhibiting a relapse-remitting pattern that necessitates multiple lines of therapy. It is now well-established …

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The clinical landscape of CAR NK cells

Lasse Vedel Jørgensen, Emil Birch Christensen, Mike Bogetofte Barnkob, Torben Barington

Chimeric antigen receptor (CAR) NK cell therapy has emerged as a promising alternative to CAR T cell therapy, offering significant advantages in terms of safety and versatility. Here we explore the current clinical landscape of CAR NK cells, and their application in …

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Droplet-based Cytotoxicity Assay to Assess Chimeric Antigen Receptor T cells at the Single-cell Level

Zelvera Usheva, David Leander Petersen, Torben Barington, Peter Mouritzen et autres

The assessment of the cytotoxic potential of T cell-based therapies, such as chimeric antigen receptor (CAR) T cell treatments, is instrumental in assessing their efficacy and is a prerequisite for clinical application. However, traditional cytotoxicity assays are conducted as bulk assays and …

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Evaluating the Non-Specific Effects of Bcg Vaccination on the Immune System and Serological Response to Influenza Vaccination in the Elderly: A Randomised Controlled Trial

Anne Marie Rosendahl Madsen, Frederik Schaltz‐Buchholzer, Ramona Trebbien, Rutger Jan Röring et autres

dk, Guinée-Bissau, nl, us (code pays fourni par la source)

Bi-Winning:Develpment of Dual-Targeting CD19 and BAFF-R CAR T cells

Kimmie B. Colmorten, Zelvera Usheva, Julia Heiselberg, Mia Andersen et autres

Correction: Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19

Maria Ormhøj, Irene Scarfò, Maria L. Cabral, Stefanie R. Bailey et autres

Effect of Bcg Vaccination on the Serological Response to Sars-Cov-2 Exposure Among Danish Health Care Workers: An Observational Study within a Randomised Clinical Trial

Anne Marie Rosendahl Madsen, Lise Gehrt, Torben Barington, Morten Bjerregaard-Andersen et autres

dk, nl, Guinée-Bissau (code pays fourni par la source)