Wei Yuan

Electron-Shuttling Mechanisms Drive Proximity Labeling to Unveil Tumor Marker Characteristics in Ovarian Cancer from Clinical Samples

Wei Yuan, Lei Zheng, Zhiwei Hu, Liang Shen et autres

In this study, we presented a revolutionary proximity labeling platform, MOF-HRP-Apt, which for the first time integrated electron mediation into the horseradish peroxidase (HRP)-catalyzed proximity labeling system. This novel strategy enabled a single molecular recognition event into multiple covalent labeling events, amplifying …

gb, cn, ir (code pays fourni par la source)

Spatiotemporal multi-omics analysis uncovers NAD-dependent immunosuppressive niche triggering early gastric cancer

Pingting Gao, Chunman Zuo, Wei Yuan, Jiabin Cai et autres

Abstract Understanding the cellular origins and early evolutionary dynamics that drive the initiation of carcinogenesis is critical to advancing early detection and prevention strategies. By characterizing key molecular, cellular and niche events at the precancerous tipping point of early gastric cancer (EGC), …

cn, Éthiopie (code pays fourni par la source)

Dual Gatekeepers-Driven Signal Amplification Strategy for Precise Detection and Modulation of Ovarian Cancer Exosome Subtypes

Ying Chen, Liang Shen, Wei Yuan, Rui Guo et autres

Early detection of ovarian cancer remains a significant challenge due to the lack of symptoms in its early stages and the overlap in protein expression patterns between malignant and benign conditions. In this study, we introduce a dual gatekeepers-driven signal amplification strategy …

cn, ir (code pays fourni par la source)

Target single-strand DNA (ssDNA) Sensing Signal to Potentiate Radiation-Induced Anti-Tumor Immunoactivation

Yujun Wang, Wei Yuan, Lingyuan Kong, Ming Zhou et autres

NIR-II Luminescent Nanothermometer for Precise Assessment of Ischemic Stroke

Xiaochen Qiu, Wei Yuan, Chen Jiang, Wei Feng et autres

Ischemic stroke, an acute cerebral local blood circulation disorder caused by neurological deficit syndrome, has emerged as a prominent ailment that can affect the well-being and quality of life of the elderly. The difficulty in early assessment and narrow therapeutic time window …

cn, pt (code pays fourni par la source)

Corrigendum to “Multi-omics joint analysis reveals the mechanism of action of the traditional Chinese medicine Marsdenia tenacissima (Roxb.) Moon in the treatment of hepatocellular carcinoma” [J. Ethnopharmacol. 293 (2022) 115285]

Siyu Li, Wenhan Pei, Wei Yuan, Dan Yu et autres

cn, mo (code pays fourni par la source)

Astragalus mongholicusbunge and Angelica sinensis botanical drug decoction mitigates lung inflammation through NOX4/TGF-β1/SMAD3 signaling

Zhifeng Yang, Yuqian Chang, Tong Zhou, Wenwen Sui et autres

Introduction Astragalus mongholicus bunge and Angelica sinensis are botanical drugs rich in beneficial nutrients and health-promoting metabolites. Their roots can be decocted to a botanical drug decoction “Danggui Buxue Tang (DBT),” demonstrating human anti-inflammatory Methods Here, we evaluate the mitigating function of …

cn, us (code pays fourni par la source)

Highly Transparent, Conductive, and Mechanically Robust Hydrogels via Rapid In Situ Synthesis for Flexible Electronics

Wei Yuan, Jie Zhao

Abstract Hydrogels face challenges as flexible electronic materials, including complex preparation processes and difficulty in balancing frost resistance, water retention, and mechanical properties. Here, a cost‐effective and efficient strategy for in situ rapid synthesis of hydrogels with Mo 2 C‐derived molybdenum polyoxometalates …

cn (code pays fourni par la source)

A case of quadruple wild-type gastrointestinal stromal tumor with CDC42BPB::NTRK3 fusion and abundant lymphoid infiltration

Wentao Xiang, Wei Yuan, Lei Ren, Wen Huang et autres

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. The most common mutations in GISTs are those in receptor tyrosine kinase (KIT) and platelet-derived growth factor receptor alpha (PDGFRA). GISTs without KIT or PDGFRA mutations are defined …

cn (code pays fourni par la source)

Mesoporous CeO2 Particle Abrasives with High Specific Surface Area for Enhanced Chemical Mechanical Polishing Performance

Jinhua Liu, Linyi Shen, Wenjing Hou, Wei Yuan et autres

In this paper, CeO2mesoporous spheres were prepared by an effective method for application as abrasive particles in chemical mechanical polishing (CMP). It is found that slurry containing the mCeO2provided scratch-free surfaces and improved removal rate by atomic force microscopy (AFM).

cn (code pays fourni par la source)

Stealth Nanoparticles with a “Self-Consuming” Shell for Long-Term Blood Vessel Imaging

Tianye Cao, Wei Yuan, Yilin Gao, Xianmei Zou et autres

The development of lanthanide-doped upconversion nanoparticle (UCNP)-based imaging with minimal autofluorescence and improved penetration depth is important in medical applications. Exogenous nanocarriers readily adsorb plasma proteins following intravenous administration (<0.5 min), resulting in the formation of a protein corona on the fixed …

cn (code pays fourni par la source)

Ligand Strategies for Regulating Atomically Precise CeO2 Nanoparticles: From Structure to Property

Peiling Du, Simin Li, Qinghua Xu, Ayisha He et autres

The increasing interest in studying the structure–property relationships of ceria dioxide (CeO2) relies on the fact that many factors are key to determining the performance of CeO2 materials. Despite the great advances achieved, it remains a formidable challenge to regulate CeO2 nanoparticles …

cn (code pays fourni par la source)