Accès ouvert
2025
article
OpenAlex
Giacomo Vezzani, Viola Viviani, Martina Audagnotto, Alessandro Rossi et autres
Introduction: The 4CMenB vaccine licensed against serogroup B Neisseria meningitidis (MenB) contains three recombinant proteins and Outer Membrane Vesicles (OMV) from a New Zealand epidemic strain. The protective response mediated on differentmeningococcal strains has been historically ascribed to one of the four …
it, ar
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Accès ouvert
2024
article
OpenAlex
Daniele Veggi, Chelsy C. Chesterman, Laura Santini, Ying Huang et autres
serogroup B (MenB) is the leading cause of such disease in developed countries. Two vaccines, 4CMenB and MenB-fHbp, that protect against MenB are available and include one or two forms respectively of factor H binding protein (fHbp), a key protective antigen. Studies …
us
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Accès ouvert
2019
article
OpenAlex
Giulia Anselmi, Maria Elisa Giuliani, Giacomo Vezzani, Rossella Ferranti et autres
Among the Herpesviridae, human cytomegalovirus (HCMV) owns the largest genome and displays a huge coding potential. Here, we characterized the UL5 gene product (pUL5) of the clinical isolate TR strain. The protein was predicted as a 166-amino-acid membrane protein with a theoretical …
it
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Accès ouvert
2018
article
OpenAlex
Marzia Monica Giuliani, Erika Bartolini, Barbara Galli, Laura Santini et autres
4CMenB is the first broad coverage vaccine for the prevention of invasive meningococcal disease caused by serogroup B strains. To gain a comprehensive picture of the antibody response induced upon 4CMenB vaccination and to obtain relevant translational information directly from human studies, …
it
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Accès ouvert
2017
article
OpenAlex
Luca Marchetti, Emilio Siena, Mario Lauria, Denise Maffione et autres
Systems biology has been recently applied to vaccinology to better understand immunological responses to the influenza vaccine. Particular attention has been paid to the identification of early signatures capable of predicting vaccine immunogenicity. Building from previous studies, we employed a recently established …
it, us
(code pays fourni par la source)
Accès ouvert
2013
preprint
OpenAlex
Nicola Pacchiani, Stefano Censini, Ludovico Buti, A Covacci
This review discusses the multiple roles of the CagA protein encoded by the cag pathogenicity island of Helicobacter pylori and highlights the CagA degradation activities on p53. By subverting the p53 tumor suppressor pathway CagA induces a strong antiapoptotic effect. Helicobacter pylori …
it, gb
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Accès ouvert
2012
article
OpenAlex
Mirko Cortese, Stefano Calò, Romina D’Aurizio, Anders E. Lilja et autres
The human cytomegalovirus (HCMV) protein RL13 has recently been described to be present in all primary isolates but rapidly mutated in culture adapted viruses. Although these data suggest a crucial role for this gene product in HCMV primary infection, no function has …
it, us
(code pays fourni par la source)