Laura Santini

Human monoclonal antibodies targeting subdominant meningococcal antigens confer cross-protection against gonococcus

Marco Troisi, Monica Fabbrini, Samuele Stazzoni, Viola Viviani et autres

Gonococcus, a bacterium resistant to most antibiotics, causes more than 80 million cases of gonorrhea annually and is considered a high-priority pathogen by the World Health Organization. Recently, vaccine development prospects were boosted by reports that licensed meningococcus serogroup B (MenB) vaccines …

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Isolation of human monoclonal antibodies from 4CMenB vaccinees reveals PorB and LOS as the main OMV components inducing cross-strain protection

Giacomo Vezzani, Viola Viviani, Martina Audagnotto, Alessandro Rossi et autres

Introduction: The 4CMenB vaccine licensed against serogroup B Neisseria meningitidis (MenB) contains three recombinant proteins and Outer Membrane Vesicles (OMV) from a New Zealand epidemic strain. The protective response mediated on differentmeningococcal strains has been historically ascribed to one of the four …

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Bactericidal human monoclonal antibody 1B1 shows specificity for meningococcal factor H binding protein variant 2 and displaces human factor H

Daniele Veggi, Chelsy C. Chesterman, Laura Santini, Ying Huang et autres

serogroup B (MenB) is the leading cause of such disease in developed countries. Two vaccines, 4CMenB and MenB-fHbp, that protect against MenB are available and include one or two forms respectively of factor H binding protein (fHbp), a key protective antigen. Studies …

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Antigenic determinants driving serogroup-specific antibody response to Neisseria meningitidis C, W, and Y capsular polysaccharides: Insights for rational vaccine design

Gian Pietro Pietri, Sara Bertuzzi, Katarina Karničar, Luca Unione et autres

Meningococcal glycoconjugate vaccines sourced from capsular polysaccharides (CPSs) of pathogenic Neisseria meningitidis strains are well-established measures to prevent meningococcal disease. However, the exact structural factors responsible for antibody recognition are not known. CPSs of Neisseria meningitidis serogroups Y and W differ by …

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Human monoclonal antibodies reveal subdominant gonococcal and meningococcal cross-protective antigens

Marco Troisi, Monica Fabbrini, Samuele Stazzoni, Viola Viviani et autres

ABSTRACT Gonococcus (Gc), a bacterium resistant to most antibiotics causing more than 80 million cases of gonorrhea annually, is a WHO high priority pathogen. Recently, vaccine development prospects were boosted by reports that licensed meningococcus serogroup B (MenB) vaccines provided partial protection …

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Standard e ‘requisiti minimi’ di competenza della lingua inglese. Il Progetto Inglese all’interno delle lauree triennali all’Università di Genova Il Progetto Inglese all’interno delle lauree triennali all’Università di Genova

Rita Cersosimo, Laura Santini

This essay is an account of the development and implementation of the ‘English Project’ at the University of Genoa, aimed at establishing a language standard at B1 level, assessing freshers, and providing a structured path if such proficiency is not met. The …

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Elucidating the Structural and Minimal Protective Epitope of the Serogroup X Meningococcal Capsular Polysaccharide

Gian Pietro Pietri, Marta Tontini, Barbara Brogioni, Davide Oldrini et autres

Despite the considerable progress toward the eradication of meningococcal disease with the introduction of glycoconjugate vaccines, previously unremarkable serogroup X has emerged in recent years, recording several outbreaks throughout the African continent. Different serogroup X polysaccharide-based vaccines have been tested in preclinical …

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Scenes of Vulnerability in You Narratives: Winterson’s PowerBook and Egan’s Black Box

Laura Santini

Framed within the current knowledge age you-culture, textual you is first discussed as a philosophical and ethical address. A specific textual analysis follows to investigate a narrative mode that the existing narratological taxonomy finds it hard to accommodate, while authors, aiming at …

Bactericidal antibodies against hypervirulent Neisseria meningitidis C field strains following MenC-CRM or MenACWY-CRM priming and MenACWY-CRM booster in children

Marzia Monica Giuliani, Alessia Biolchi, Pavitra Keshavan, Maria Moriondo et autres

analysis, we assessed bactericidal activity of antibodies in sera from children primed with MenACWY-CRM or MenC-CRM conjugate vaccines and receiving a MenACWY-CRM booster dose against 5 meningococcal C (MenC) strains isolated from IMD cases. Sera collected from 90 infants/toddlers who participated in …

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Four-component Meningococcal Serogroup B Vaccine Induces Antibodies With Bactericidal Activity Against Diverse Outbreak Strains in Adolescents

Alessia Biolchi, Sara Tomei, Laura Santini, Rita La Gaetana et autres

BACKGROUND: Neisseria meningitidis serogroup B (MenB) causes most meningitis outbreaks worldwide. We evaluated the ability of the 4-component MenB vaccine (4CMenB) to induce bactericidal activity against outbreak strains in adolescents. METHODS: Individual sera from 20 United States and 23 Chilean adolescents who …

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4CMenB vaccine induces elite cross-protective human antibodies that compete with human factor H for binding to meningococcal fHbp

Daniele Veggi, Federica Bianchi, Laura Santini, Paola Lo Surdo et autres

Neisseria meningitidis serogroup B (MenB) is the leading cause of meningococcal meningitis and sepsis in industrialized countries, with the highest incidence in infants and adolescents. Two recombinant protein vaccines that protect against MenB are now available (i.e. 4CMenB and MenB-fHbp). Both vaccines …

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7. Two-Dose 4CMenB Vaccination in Adolescents Elicits a Bactericidal Activity against 15 Outbreak-Representative Meningococcal Strains

Alessia Biolchi, Sara Tomei, Laura Santini, Rita La Gaetana et autres

Abstract Background Meningococcal outbreaks have often been associated with N. meningitidis serogroup B (MenB) in high-income countries. We examined whether antibodies elicited by the 4-component MenB vaccine (4CMenB) in adolescents could induce complement-mediated bacterial killing of a panel of 14 genetically diverse …

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