Chuen‐Miin Leu

The Hedgehog Pathway Promotes Monocytes Infiltration Through CCL20 – CCR6 Axis in Hepatocellular Carcinoma

Y Hsu, Chen‐Yi Chang, Chuen‐Miin Leu, Kuo‐Hsin Chen et autres

Hepatocellular carcinoma (HCC) is one of the leading cancers worldwide, and its development is strongly associated with the tumour microenvironment, particularly fibrosis and chronic inflammation. This study aims to investigate the role of the Hedgehog (Hh) pathway, a key signalling pathway in …

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Aldo-keto reductase family member C3 (AKR1C3) promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α

Kuo‐Shyang Jeng, PO-YU CHENG, YUEH-HSIEN LIN, Po-Chun Liu et autres

Hepatocellular carcinoma (HCC) is a leading cause of death worldwide. Current therapies are effective for HCC patients with early disease, but many patients suffer recurrence after surgery and have a poor response to chemotherapy. Therefore, new therapeutic targets are needed. We analyzed …

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FCRL1 immunoregulation in B cell development and malignancy

Murali Krishna Mamidi, Jifeng Huang, Kazuhito Honjo, Ran Li et autres

Immunotherapeutic targeting of surface regulatory proteins and pharmacologic inhibition of critical signaling pathways has dramatically shifted our approach to the care of individuals with B cell malignancies. This evolution in therapy reflects the central role of the B cell receptor (BCR) signaling …

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The Role of Endoglin in Hepatocellular Carcinoma

Kuo‐Shyang Jeng, I‐Shyan Sheen, Shu‐Sheng Lin, Chuen‐Miin Leu et autres

Endoglin (CD105) is a type-1 integral transmembrane glycoprotein and coreceptor for transforming growth factor-β (TGF-β) ligands. The endoglin/TGF-β signaling pathway regulates hemostasis, cell proliferation/migration, extracellular matrix (ECM) synthesis and angiogenesis. Angiogenesis contributes to early progression, invasion, postoperative recurrence, and metastasis in hepatocellular …

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The Role of Smoothened in Cancer

Kuo‐Shyang Jeng, I‐Shyan Sheen, Chuen‐Miin Leu, Ping‐Hui Tseng et autres

Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH …

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Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review)

Kuo‐Shyang Jeng, Chi‐Juei Jeng, Wen‐Juei Jeng, I‐Shyan Sheen et autres

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-associated mortality worldwide. Hepatocarcinogenesis involves numerous interlinked factors and processes, including the Sonic hedgehog (Shh) signaling pathway, which participates in the carcinogenesis, progression, invasiveness, recurrence and cancer stem cell maintenance of HCC. …

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Deltex1 suppresses T cell function and is a biomarker for diagnosis and disease activity of systemic lupus erythematosus

Chuen‐Miin Leu, Tzu-Sheng Hsu, Yu‐Ping Kuo, Ming‐Zong Lai et autres

Rheumatology 2019;58:719–28. doi:10.1093/rheumatology/key418 In the original article, some of the authors were incorrectly affiliated with the wrong institutions. These have now been corrected. The Publisher apologizes for the error.

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Deltex1 suppresses T cell function and is a biomarker for diagnosis and disease activity of systemic lupus erythematosus

Chuen‐Miin Leu, Tzu-Sheng Hsu, Yu‐Ping Kuo, Ming‐Zong Lai et autres

OBJECTIVE: Deletion of Deltex1 (DTX1) in mice caused hyperactivation of T cells and lupus-like autoimmune syndromes, however, the association of DTX1 with human autoimmune diseases is totally unknown. This study investigated the role of DTX1 in human T cell functions and its …

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Fc Receptor–like Proteins (FCRL): Immunomodulators of B Cell Function

GGötz R. A. Ehrhardt, Chuen‐Miin Leu, Shuangyin Zhang, Güzide Aksu et autres

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An extended family of Fc receptor relatives

Randall S. Davis, Goetz R. A. Ehrhardt, Chuen‐Miin Leu, Masayuki Hirano et autres

A surprising number of Fc receptor (FcR) relatives have been recognized recently with the potential capacity to modulate innate and adaptive immune responses. The six human FcR homologs (FcRH1-6), which belong to a phylogenetically conserved gene family, have variable numbers of extracellular …

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The inhibitory potential of Fc receptor homolog 4 on memory B cells

Götz R. A. Ehrhardt, Randall S. Davis, Joyce T. Hsu, Chuen‐Miin Leu et autres

Fc receptor homolog 4 (FcRH4) is a B cell-specific member of the recently identified family of FcRHs whose intracellular domain contains three potential immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The signaling potential of this receptor, shown here to be preferentially expressed by memory …

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Autocrine stimulation by insulin-like growth factor I is involved in the growth, tumorigenicity and chemoresistance of human esophageal carcinoma cells

Young-Chau Liu, Chuen‐Miin Leu, Fen-Hwa Wong, Wan-Shung Fong et autres

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