Ana J. García‐Sáez

Replicate Data For: Cancer-associated BCL-2 mutants reveal mechanisms towards venetoclax resistance

Ian de Ridder, Jonas Aufdermauer, Mahjoobeh Ehsani, Marasim Khan et autres

This dataset includes all underlying data integrated in the publication in Advanced Science by Aufdermauer and de Ridder et al. and contains all data necessary to replicate the published figures. The data consist of densitometric western blot data and numerical data of …

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Disruption of MCL1/BOK transmembrane interaction as a novel strategy to induce cell death in tumours

M. Buffa, D. Leiva, A. Garcia-Jareño, M. Garcés-Flores et autres

MCL1, an anti-apoptotic BCL-2 family member, is frequently overexpressed in multiple tumour types and correlates with poor prognosis; however, targeting its cytosolic domain to release pro-apoptotic effectors has been limited by cardiotoxicity in clinical trials. In this study, we describe a chemically …

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DRP1 and MID49 co-diffusion scans mitochondria for fission

Cristiana Zollo, David Gomez Suarez, Elmira Parvindokht Bararpour, Andreas Jenner et autres

DRP1 is a dynamin-related large GTPase responsible for mitochondrial fission, which ensures proper mitochondrial distribution, morphology and quality control. Despite its relevance, the mechanism of mitochondrial division, especially regarding the dynamic regulation of DRP1, remains elusive. Here we report that DRP1 oligomers …

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Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis

Florêncio Porto Freitas, Hamed Alborzinia, Ancély Ferreira dos Santos, Palina Nepachalovich et autres

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A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis

Svenja Lorenz, Adam Wahida, Mark J. Bostock, Tobias Seibt et autres

Ferroptosis, driven by uncontrolled peroxidation of membrane phospholipids, is distinct from other cell death modalities because it lacks an initiating signal and is surveilled by endogenous antioxidant defenses. Glutathione peroxidase 4 (GPX4) is the guardian of ferroptosis, although its membrane-protective function remains …

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Mitochondrial dynamics and pore formation in regulated cell death pathways

Lisa Hohorst, Uris Ros, Ana J. García‐Sáez

Mitochondria act as central hubs for cell death signaling. During apoptosis and regulated necrosis (pyroptosis, necroptosis, and ferroptosis), mitochondria undergo drastic changes including membrane permeabilization, fragmentation, and loss of membrane potential. However, dissection of the mechanisms underlying these processes is challenging because …

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Dynamic regulation of cell death signaling

Asma Majoul, Ana J. García‐Sáez

There are many ways for a cell to die, but each cell only dies once, causing an inherent variability that results from common triggers activating interconnected signaling networks that diverge at key decision points during cell death initiation, progression, and execution. Despite …

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Activator of apoptosis harakiri ( HRK ) localisation at mitochondria alters mitochondrial morphology independently of other BCL ‐2 proteins

Louise King, Ana J. García‐Sáez

The activator of apoptosis harakiri (HRK) is a pro-apoptotic BCL-2 homology 3 (BH3)-only protein of the apoptosis regulator Bcl-2 (BCL-2) family that is mainly expressed in neuronal and haematopoietic tissues. How specific HRK protein domains contribute to its pro-apoptotic function, and what …

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Author response for "Activator of apoptosis harakiri (HRK) localisation at mitochondria alters mitochondrial morphology independently of other BCL-2 proteins"

Louise King, Ana J. García‐Sáez

Mechanical forces drive mitochondrial matrix extrusion and apoptotic pore growth

Andreas Jenner, Timo Dellmann, Hyuntae Kim, David Gomez et autres

Abstract Apoptotic pore opening by BAX and BAK at the mitochondrial outer membrane is a key step in the cell commitment to death. The subsequent inner membrane extrusion and permeabilization releases mitochondrial DNA into the cytosol, which can trigger inflammatory signaling. However, …

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Special Issue – Cell Biology of Mitochondria

Ana J. García‐Sáez, Heidi M. McBride

It has been an honor to edit this special issue on the ‘Cell Biology of Mitochondria’ for Journal of Cell Science (JCS). The impact of mitochondrial research on all fields of biomedical sciences continues to grow as new discoveries open unexpected pathways …

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Convolutional Neural Network approach to classify mitochondrial morphologies

Soumaya Zaghbani, Lukas Faber, Ana J. García‐Sáez

The morphology of the mitochondrial network is a major indicator of cellular health and function, with changes often linked to various physiological and pathological conditions. As a result, efficient methods to quickly assess mitochondrial shape in cellular populations from microscopy images in …

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