Accès ouvert
2026
article
OpenAlex
Samuel T. Ruzzene, Vinícius P. Garcia, Auburn R. Berry, Madeleine F. Stone et autres
Despite an improved understanding of many of the pathological consequences associated with human obesity, factors that initiate, promote, and accelerate cerebrovascular events are not completely understood. This study provides novel data demonstrating that circulating EEVs from adults with obesity adversely affect eNOS …
us
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2026
article
OpenAlex
Auburn R. Berry, Samuel T. Ruzzene, Vinícius P. Garcia, Kendra N. Wegerson et autres
Aging is the preeminent risk factor for ischemic stroke. The mechanisms underlying the age-related increase in stroke risk and incidence are complex, diverse, and not completely understood. This study provides novel data implicating circulating endothelial cell-derived extracellular vesicles (EEVs) as a novel …
us
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Accès ouvert
2026
article
OpenAlex
Whitney B. Valenti, Samuel T. Ruzzene, Auburn R. Berry, Nathalie C. Orozco-Fersiva et autres
The cerebrovascular protective effects of estrogen are diverse, complex, and not fully understood. This study provides novel data demonstrating that 17β-estradiol decreases oxidative stress, enhances apoptotic resistance, and increases fibrinolytic capacity in human brain microvascular endothelial cells in vitro. These changes in …
us
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Accès ouvert
2026
preprint
OpenAlex
Andrew Joon Park, Christopher A. DeSouza, Genevieve Madera, Clare Morey et autres
ABSTRACT Background Individuals with spinal cord injury (SCI) experience accelerated atherosclerotic cardiovascular disease that is not fully explained by traditional risk factors. Endothelial dysfunction is a key mechanism in atherosclerosis. We tested the hypothesis that endothelium-dependent vasodilation is impaired in adults with …
us
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Accès ouvert
2026
article
OpenAlex
Douglas R. Seals, Christopher A. DeSouza, Hirofumi Tanaka, Kerrie L. Moreau et autres
) almost twice that of nonexercising postmenopausal women, in part due to a larger total blood volume. The masters runners showed stable body mass with age/menopause and exhibited much smaller age-related differences in total body fatness and abdominal adiposity than nonexercising women, …
us
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Accès ouvert
2026
article
OpenAlex
Garett S. Jackson, Hashim Islam, Alexandre Abílio de Souza Teixeira, Jordan Boultbee et autres
AIMS: Extracellular vesicles (EVs) facilitate intercellular communication and reflect cellular phenotypes. Large-sized EVs (200-1000 nm), commonly referred to as microvesicles (MVs), are released during cellular activation or apoptosis and may serve as biomarkers in chronic disease. The present study aimed to characterize …
ca, gb, us
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Accès ouvert
2025
article
OpenAlex
Samuel T. Ruzzene, Auburn R. Berry, Vinícius P. Garcia, Whitney B. Valenti et autres
Obesity is associated with profound impairment in the capacity of the vascular endothelium to release tissue-type plasminogen activator (t-PA), the primary mechanism underlying endogenous thrombolysis. Circulating endothelial cell-derived extracellular vesicles (EMVs) have been linked to endothelial dysfunction. This study demonstrates that circulating …
us
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Accès ouvert
2025
article
OpenAlex
Christian S DeSouza, Kelly A. Stockelman, Jamie G. Hijmans, Tyler D. Bammert et autres
Aging is associated with progressive decline in endothelium-dependent vasodilation. Mechanisms underlying this decline in endothelial function are not fully understood. Circulating endothelial cell-derived extracellular vesicles (EMVs) have been linked to endothelial dysfunction. The results of the study demonstrate that circulating EMVs increase …
us
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Accès ouvert
2025
article
OpenAlex
Auburn R. Berry, Samuel T. Ruzzene, Emily I. Ostrander, Kendra N. Wegerson et autres
Erythritol, a common non-nutritive sweetener, is associated with increased risk of cardiovascular and cerebrovascular events. This study provides novel data, demonstrating that erythritol (at a concentration typically contained in a standard-size commercially available artificially sweetened beverage) adversely affects brain microvascular endothelial cell …
us, fr
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2025
article
OpenAlex
Auburn Berry, Samuel T. Ruzzene, João Eduardo Izaías, Jared J. Greiner et autres
Adults with obesity demonstrate accelerated rates of atherosclerosis, as well as increased incidence of myocardial infarction and stroke. As such, obesity reduces the number of years lived free of cardiovascular disease (CVD) and increases the number of years lived with CVD, contributing …
us
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2025
article
OpenAlex
Vinícius P. Garcia, Danielle L. Kirkman, Auburn Berry, Samuel T. Ruzzene et autres
Chronic low-grade inflammation in chronic kidney disease (CKD) is associated with an increased risk of cardiovascular diseases (CVD), including stroke. Circulating endothelial microvesicles (EMVs), a subset of extracellular vesicles, have been linked to the etiology of ischemic stroke. Indeed, EMVs can cross …
us
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2025
article
OpenAlex
Auburn Berry, Samuel T. Ruzzene, João Eduardo Izaías, Joshua Holzer et autres
Erythritol is a widely used non-nutritive sweetener that has been purported to be a safe alternative to sugar due to its minimal impact on blood glucose and insulin levels. However, recent evidence has linked erythritol to increased risk of cardiovascular and cerebrovascular …
us
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