Wonjong Lee

Abstract 5782: Machine learning and structure-guided discovery of EP300-selective, orally bioavailable degraders for cancer therapy

Ho Yeon Nam, Sun Young Jang, SeokJong Kang, Yongtaek Lee et autres

Abstract EP300 and CBP are closely related transcriptional co-activators with histone acetyltransferase (HAT) activity that regulate gene expression, cell proliferation, and differentiation. In normal tissues, EP300 and CBP compensate for each other; however, CBP-deficient tumor cells become selectively dependent on overexpressed EP300, …

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Latilactobacillus curvatus DCF0620 and postbiotics derived from soybean germ reduce colitis severity by modulating fibrosis and gut dysbiosis

Jin-Sil Park, Hye Yeon Kang, JeongWon Choi, Wonjong Lee et autres

Background Given that microbiota dysbiosis is closely linked to the initiation and progression of inflammatory bowel disease (IBD), extensive research is underway to utilize beneficial probiotics as a therapeutic strategy for IBD. In this study, we compared the therapeutic efficacy of Lacticaseibacillus …

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Abstract B117: Discovery of potent, selective, and orally bioavailable heterobifunctional EP300 degraders

Yongtaek Lee, Sun Young Jang, Seok-Jong Kang, Ho Yeon Nam et autres

Abstract EP300 and CBP are closely related transcriptional coactivators possessing histone acetyltransferase (HAT) activity, playing essential roles in the regulation of gene expression, cell proliferation, and differentiation. Both are frequently dysregulated or overexpressed in various cancers. In normal tissues, EP300 and CBP …

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A preliminary exploration of histopathological assessment as a complementary approach to anti-hemorrhagic potency testing of Gloydius antivenom in Korea

K.S. Han, Wonjong Lee, Kwang‐Young Song, Hong Kyu Lee

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Changes in regulatory requirements for potency testing of snake antivenom in Korea

Wonjong Lee, Hyun Jeong Kim, Young-Jei Oh, Su Kyoung Seong et autres

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Genomic and metabolomic analysis of Latilactobacillus sakei DCF0720 for black soybean yogurt fermentation

Dong Hyeon Lee, Wonjong Lee, Dong‐Ho Shin, Haecheon Im et autres

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N-tert-butoxycarbonyl-methylenedioxymethamphetamine, an methylenedioxymethamphetamine derivative, exhibits rewarding and reinforcing effects by increasing dopamine levels.

Dong‐Hyun Youn, Cheolmin Jo, Jin Mook Kim, Youngki Hong et autres

An N-protected methylenedioxymethamphetamine (MDMA), N-tert-butoxycarbonyl-3,4-methylenedioxymethamphetamine (t-BOC-3,4-MDMA), contains tert-butoxycarbonyl and can remain undetected in the illicit drug market. It is a new type of precursor substance that is not a chemical intermediate and can be converted into a controlled substance, MDMA, by deprotection …

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Protective effect of soy germ-fermented postbiotics derived from Lacticaseibacillus paracasei DCF0429 (SGPB-DCF0429) in human reconstituted skin

Wonjong Lee, Hae-cheon Im, Yoon-Bok Lee, Jaekwon Choi

Postbiotics are non-viable microorganisms and their components that provide health benefits to their hosts. At this time, the potential effects of food-based postbiotics have not been reported. This study was designed to isolate lactic acid bacteria (LAB) from traditional Korean fermented foods …

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Estimating Stranded Assets of Coal Power Plants under the National Greenhouse Abatement Plan

Wonjong Lee, Hyunkyung Joo, Byungchan Chun, Yoon‐Mo Koo

석탄발전은 높은 경제성과 신뢰성을 바탕으로 한국 산업과 경제 발전에 큰 기여를 하였다. 하지만 최근 미세먼지 이슈와 더불어 인류가 당면한 기후변화 문제 해결을 위해 석탄발전 비중의 축소가 필연적인 상황이다. 본 연구에서는 국가 온실가스 감축계획 및 10차 전력수급기본계획 하에서 ’36년까지 폐지 예정인 석탄설비 28기에 …

Discriminative stimulus and reinforcing effects of diclazepam in rodents

Wonjong Lee, Jung Won Lee, Sungsun Kim, Jin Mook Kim et autres

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Determination of the Chemical Stability of Cyanocobalamin in Medical Food by a Validated Immunoaffinity Column-Linked HPLC Method

Wonjong Lee, Yoon-Bok Lee, Moon Haeng Huh, Jae Kwon Choi

Cyanocobalamin, which plays an essential role in the body, is a synthetic form used in medical food. This present study aimed to develop an HPLC analysis method for determination cyanocobalamin and investigate the stability of cyanocobalamin in medical food. Validation of the …

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The abuse potential of prolintane in rodents: Behavioral pharmacology approaches

Wonjong Lee, Jung Won Lee, Jin Mook Kim, Youngki Hong et autres

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