Megumi Inoue

WCN26-3373 IFNAR2 COVID-19 Risk Variant Is Associated with Disease Severity in Kidney Transplant Recipients

Megumi Inoue, Kumiko Torisu, Yuta Matsukuma, Kenji Ueki et autres

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Association Between Gastrointestinal-Related Quality of Life and Frailty Using Baseline Data of the Prospective Cohort Study (JUSTICE-TOKYO Study)

Daisuke Asaoka, Osamu Nomura, Koji Sugano, Kei Matsuno et autres

Objective: To determine the prevalence of frailty and examine its association with gastrointestinal-related quality of life (QOL) among older outpatients in a geriatric hospital. Methods: This cross-sectional study involved 1042 outpatients (age: ≥65 years) diagnosed using the revised Japanese version of the …

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EP.06B.04 Aging Alteration of Biomarkers and Its Prognostic Role in Elderly Lung Cancer Patients Treated with Adjuvant S-1 Chemotherapy

Junichi Soh, Hiroshi Yamamoto, Norihito Okumura, Hiroyuki Suzuki et autres

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MO41-6 Chemotherapy for metastatic or recurrent soft tissue sarcoma: real-world experience in a single institute

Osamu Maeda, T. Shimokata, A. Mitsuma, Hiroshi Urakawa et autres

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Association between dietary variety status and sarcopenia as defined by the Asian Working Group for Sarcopenia 2019 consensus in older outpatients at a hospital specializing in geriatric medicine: A cross‑sectional study with baseline data of prospective cohort study (JUSTICE‑TOKYO study)

Daisuke Asaoka, Tadatomo Suga, Kei Matsuno, Nobuto Shibata et autres

To the best of our knowledge, little is known about the association between dietary variety status and sarcopenia in university-affiliated geriatric hospital in elderly. The present study aimed to investigate, in a multidisciplinary setting, the prevalence of sarcopenia and association between dietary …

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Drug-induced thrombocytopenia associated with trastuzumab in a patient with HER2-positive recurrent gastric cancer

Yuko Takano, Satoshi Furune, Yuki Miyai, Sachi Morita et autres

Here, we report a 57-year-old female patient with HER2-positive recurrent gastric cancer who experienced drug-induced thrombocytopenia associated with trastuzumab, a humanized anti-HER2 monoclonal antibody. Shortly after the initiation of S-1, oxaliplatin, and trastuzumab chemotherapy, the patient experienced severe thrombocytopenia and did not …

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P44-9 A case of recurrent gastric cancer with drug-induced immune thrombocytopenia caused by trastuzumab

Yuko Takano, Satoshi Furune, Sachi Morita, Megumi Inoue et autres

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Comparison of immunogenicity between candidate influenza A(H3N2) virus vaccine strains in Japan: A randomized controlled trial using a monovalent vaccine of A/Saitama/103/2014 (CEXP-002) and A/Hong Kong/4801/2014 (X-263)

Tetsuo Kase, Megumi Inoue, Saeko Morikawa, Hiroko Kumashiro et autres

BACKGROUND: For the 2017-18 influenza season, A/Saitama/103/2014 (CEXP-002) (Saitama strain) was antigenically more similar to prior circulating strains than A/Hong Kong/4801/2014 (X-263) (Hong Kong strain) in a ferret model and was selected as the A(H3N2) vaccine virus strain in Japan. However, the …

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Gender Differences in the Effects of Cortisol and Dehydroepiandrosterone on Brain Derived Neurotrophic Factor in Patients with Major Depression

Hiroko Shukuzawa, Hajime Baba, Hitoshi Maeshima, Takahisa Shimano et autres

Levels of serum brain derived neurotrophic factor (BDNF) are lower in patients with major depressive disorder (MDD). The adrenal cortex secretes the corticosteroids cortisol and dehydroepiandrosterone (DHEA) under stress condition, and serum levels of DHEA are gender-dependent. Although BDNF expression is associated …

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Serum levels and mutual correlations of amyloid β in patients with depression

Seita Yasuda, Hajime Baba, Hitoshi Maeshima, Takahisa Shimano et autres

AIM: Epidemiological studies have shown that depression is a risk factor for Alzheimer's disease (AD). Although the biological mechanism underlying the link between depression and AD is unclear, altered amyloid β (Aβ) metabolism in patients with depression has been suggested as a …

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Pharmacokinetics and Safety of Single-Dose Esaxerenone in Japanese Subjects with Mild to Moderate Hepatic Impairment

Akifumi Kurata, Takafumi Yoshida, Megumi Inoue, Tomoko Ishizuka et autres

The mineralocorticoid receptor (MR) blocker esaxerenone is a new treatment for hypertension in Japan and under development for treatment of diabetic nephropathy. Hepatic impairment is known to impact the pharmacokinetics (PKs) of other MR blocking drugs. The aim of the present study …

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Epithelial Lining Fluid and Plasma Concentrations of Dalbavancin in Healthy Adults after a Single 1,500-Milligram Infusion

Urania Rappo, Michael W. Dunne, Sailaja Puttagunta, James S. Baldassarre et autres

Dalbavancin is a lipoglycopeptide antibiotic with a prolonged half-life. A phase 1 study assessed dalbavancin levels in epithelial lining fluid (ELF) in 35 healthy adults using ELF bronchial microsampling up to 168 h after administration of 1,500 mg dalbavancin. The penetration of …

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