Liam Simms

Next generation nicotine product aerosol extracts exhibit reduced toxicological effects compared to cigarette smoke extracts in the ToxTracker Antioxidant and ToxProfiler MAX assays

Matthew Stevenson, Roman Wieczorek, Edgar Trelles Sticken, Sarah Jean Pour et autres

Smoking is a cause of serious diseases in adult smokers. Next generation products (NGP) can provide potentially reduced harm alternatives of nicotine delivery, due to the reductions in numbers and levels of toxicants associated with their use. These include heated tobacco and …

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P30-11 Assessment of Disposable of e-vapour products using New Approach Methodologies shows marked reductions in toxicity relative to a cigarette

Ourania Komini, Remco S. Derr, Inger Brandsma, Roman Wieczorek et autres

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P30-06 Disposable E-Vapour Products Exhibit Lower in vitro toxicological Activity Than Cigarettes

Miruna Oltean, Roman Wieczorek, S.J. Pour, Edgar Trelles Sticken et autres

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P21-01 Assessment of a range of Next Generation Nicotine products using ToxTracker® and ToxProfiler™ MAX assays reveal marked reductions in biological activity compared to a cigarette

Matthew Stevenson, Inger Brandsma, Marieke Meijer, M. Rijkers et autres

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Assessment of heated herbal products’ tobacco harm reduction potential: pre‐clinical and clinical studies

Alvaro-Flavio Marinas-Lacasta, Ian M. Fearon, Matthew Stevenson, Tasnim Abusalem et autres

Data from pre-clinical and clinical studies form part of an integrated assessment of the tobacco harm reduction (THR) potential of novel products that may act as cigarette alternatives for adult smokers. We report data from pre-clinical (emissions chemistry and in vitro toxicology) …

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P01-04 Extracts from different next generation product platforms show less potential to induce oxidative stress than extracts from cigarettes in human coronary artery endothelial cells (HCAECs) in vitro

Edgar Trelles Sticken, Torge Evenburg, S.J. Pour, Roman Wieczorek et autres

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Corrigendum: Applying new approach methodologies to assess next-generation tobacco and nicotine products

David Thorne, Damian McHugh, Liam Simms, K. Monica Lee et autres

[This corrects the article DOI: 10.3389/ftox.2024.1376118.].

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Applying new approach methodologies to assess next-generation tobacco and nicotine products

David Thorne, Damian McHugh, Liam Simms, K. Monica Lee et autres

In vitro toxicology research has accelerated with the use of in silico, computational approaches and human in vitro tissue systems, facilitating major improvements evaluating the safety and health risks of novel consumer products. Innovation in molecular and cellular biology has shifted testing …

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Optimisation of an in vitro human cardiovascular model on-a-chip for toxicological assessment of nicotine delivery products

Fiona Chapman, Luuk de Haan, Linda Gijzen, Wouter Strijker et autres

Background Smoking cigarettes is a cause of serious diseases in smokers, including cardiovascular disease. Through a pathway of endothelial dysfunction, lipid infiltration, macrophage recruitment and vascular remodeling, atherosclerosis is fundamental in the development of most cardiovascular diseases. There is an increasing number …

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The Product Science of Electrically Heated Tobacco Products: An Updated Narrative Review of the Scientific Literature

Sarah F. Cordery, Keith Thompson, Matthew Stevenson, Liam Simms et autres

Heated tobacco products represent a novel category of tobacco products in which a tobacco consumable is heated to a temperature that releases nicotine from the tobacco leaf but not to a temperature sufficient to cause combustion. Heated tobacco products may therefore have …

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Use of quantitative in vitro to in vivo extrapolation (QIVIVE) for the assessment of non-combustible next-generation product aerosols

Marjory Moreau, Liam Simms, Melvin E. Andersen, Edgar Trelles Sticken et autres

With the use of in vitro new approach methodologies (NAMs) for the assessment of non-combustible next-generation nicotine delivery products, new extrapolation methods will also be required to interpret and contextualize the physiological relevance of these results. Quantitative in vitro to in vivo …

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P14-20: Chemical and biological assessment of a Heated Tobacco Product reveals marked reductions in aerosol toxicants and in vitro toxicity compared to a combustible cigarette

Rusu Vasile, S.J. Pour, Roman Wieczorek, Edgar Trelles Sticken et autres

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