Vladimir A. Tyurin

15-LOX-catalytic bias towards ether-(alkenyl)-ETE-PEs oxidation bestows selectivity of PRO-ferroptotic cell death signaling

Yulia Y. Tyurina, Karolina Mikulska‐Ruminska, Vladimir A. Tyurin, Brian A. Kleiboeker et autres

Ether (alkyl/alkenyl) phospholipids, particularly phosphatidylethanolamine (PE) and phosphatidylcholine (PC), are broadly represented in membranes, but their physiological functions are poorly characterized. The antioxidant role of plasmalogens realized via oxidation of sn-1 vinyl bond has been associated with anti-ferroptotic regulatory function. Alternatively, peroxidation …

us, pl, nl, jp (code pays fourni par la source)

Corrigendum to: Mitochondrial bioenergetics and cardiolipin remodeling abnormalities in mitochondrial trifunctional protein deficiency

Eduardo Vieira Neto, Meicheng Wang, Austin J. Szuminsky, Lethicia Ferraro et autres

Corrigendum to: Mitochondrial bioenergetics and cardiolipin remodeling abnormalities in mitochondrial trifunctional protein deficiency

Eduardo Vieira Neto, Meicheng Wang, Austin J. Szuminsky, Lethicia Ferraro et autres

A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression

Zhangchuan Xia, Xin Ping Yang, Sviatlana N. Samovich, Yulia Y. Tyurina et autres

Ferroptosis is a tumor-suppressive mechanism with therapeutic potential. While canonical ferroptosis is usually triggered by inducers, such as erastin and RSL-3, or by glutathione peroxidase (GPX)4 loss, how ferroptosis occurs naturally in vivo without these triggers has been unclear. Building on evidence …

us (code pays fourni par la source)

Ferroptosis in Tumor Neutrophils Triggers T Cell Depletion and Limits the Effect of Immunotherapy

Ayumi Hashimoto, Fatin Mohd Jaya, Talis Spriggs, Yulia Y. Tyurina et autres

sg, us, es, cn, hk, gb (code pays fourni par la source)

Figure S10 from Targeting LxCxE Cleft Pocket of Retinoblastoma Protein in Immunosuppressive Macrophages Inhibits Ovarian Cancer Progression

Evgenii N. Tcyganov, Taekyoung Kwak, Xue Yang, Adi Narayana Reddy Poli et autres

Graphical abstract.

Figure S7 from Targeting LxCxE Cleft Pocket of Retinoblastoma Protein in Immunosuppressive Macrophages Inhibits Ovarian Cancer Progression

Evgenii N. Tcyganov, Taekyoung Kwak, Xue Yang, Adi Narayana Reddy Poli et autres

Therapeutic Rb targeting upregulates p53 expression in macrophages and the effects of ASK1 and GSK3 inhibitors on macrophage viability.

Figure S4 from Targeting LxCxE Cleft Pocket of Retinoblastoma Protein in Immunosuppressive Macrophages Inhibits Ovarian Cancer Progression

Evgenii N. Tcyganov, Taekyoung Kwak, Xue Yang, Adi Narayana Reddy Poli et autres

Therapeutic myeloid Rb targeting changes the composition of immune cell populations in the ascites of ID8-bearing mice and preferentially affects M2 type polarized macrophages.

Figure S3 from Targeting LxCxE Cleft Pocket of Retinoblastoma Protein in Immunosuppressive Macrophages Inhibits Ovarian Cancer Progression

Evgenii N. Tcyganov, Taekyoung Kwak, Xue Yang, Adi Narayana Reddy Poli et autres

Therapeutic myeloid Rb targeting preferentially affects macrophages, but not tumor cells and demonstrates the effects different from CDK4/6 palbociclib inhibitor.

Figure S8 from Targeting LxCxE Cleft Pocket of Retinoblastoma Protein in Immunosuppressive Macrophages Inhibits Ovarian Cancer Progression

Evgenii N. Tcyganov, Taekyoung Kwak, Xue Yang, Adi Narayana Reddy Poli et autres

Therapeutic Rb targeting delays tumor growth in various ovarian cancer models and demonstrates the effects non-redundant to CDK4/6 palbociclib inhibitor.

Table S1 from Targeting LxCxE Cleft Pocket of Retinoblastoma Protein in Immunosuppressive Macrophages Inhibits Ovarian Cancer Progression

Evgenii N. Tcyganov, Taekyoung Kwak, Xue Yang, Adi Narayana Reddy Poli et autres

Reagent Source Table

Figure S9 from Targeting LxCxE Cleft Pocket of Retinoblastoma Protein in Immunosuppressive Macrophages Inhibits Ovarian Cancer Progression

Evgenii N. Tcyganov, Taekyoung Kwak, Xue Yang, Adi Narayana Reddy Poli et autres

Comparison of patient survival outcome with different expression levels of RBL1/RBL2 in tumor.