Péter T. Tóth

Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses during inflammation

Priyanka Gajwani, L X Wang, Koushik Debnath, Pierina Danos et autres

Eukaryotic mitochondria are characterized by several features that represent vestiges of their prokaryotic ancestry. One such feature is the N-terminal formylation of proteins encoded by mitochondrial DNA that undergo translation by mitochondrial ribosomes. N-formylated proteins are also released by bacteria and trigger …

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Author response: Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses during inflammation

Priyanka Gajwani, Li Wang, Koushik Debnath, Pierina Danos-Diaz et autres

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Condensation of cGAS induced by Tyr242 phosphorylation and interaction with MYL6 mediates vascular innate immunity in the lung.

Bhagwati Joshi, Jagdish Chandra Joshi, Vijay Avin Balaji Raghunathrao, Vigneshwaran Velligiri et autres

in cGAS in the endothelium as critical for inducing innate immune responses to pathogens and contributing to acute lung injury.

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Abstract 6746: Biomarker-driven restoration of tumor provisional matrix signaling network reverses resistance to checkpoint inhibition immunotherapy

Daniel J. Lagal, Duncan Hong, Athanasios Papadas, Emma Geatches et autres

Abstract Specialized immune niches located in the stroma-tumor junction promote interactions between tumor-resident antigen-presenting cells and effector lymphocytes that are required for immunotherapy efficacy. We have hypothesized that this stromal-based immune crosstalk may be regulated by provisional extracellular matrix signals, analogous to …

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Kinetic and Mechanistic Study of Polycarbodiimide Formation from 4,4′-Methylenediphenyl Diisocyanate

Marcell Csécsi, Renáta Zsanett Boros, Péter T. Tóth, László Farkas et autres

In the polyurethane industry, catalytically generated carbodiimides can modify the properties of isocyanate and, thus, the resulting foams. In this work, a kinetic reaction study was carried out to investigate the formation of a simple, bifunctional carbodiimide from a widely used polyurethane …

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Local optogenetic control of genome editing and tumorigenesis in vivo using wireless implantable optoelectronics

Trisha Bansal, Min‐Kyu Lee, Courtney Coleman, Young-Mee Kim et autres

Abstract Precise spatial regulation of site-specific DNA recombination (SSR) in vivo remains a challenge due to limited tunability of current platforms. Here, we present an optogenetic approach that overcome these limitations by employing engineered light-regulated recombinase E-LightR-Cre and tunable wireless implantable optoelectronic …

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Deficiency in N-cadherin-Akt3 signaling impairs the blood-brain barrier

Quinn Lee, Wan Ching Chan, Shuangping Zhao, Harry M Hailemeskel et autres

The blood-brain barrier (BBB) restricts the passage of protein-rich fluids through tight junctions (TJs) formed between brain endothelial cells (BECs). BBB restrictiveness diminishes with aging, but the underlying mechanisms remain unclear. BECs establish physical contact with pericytes via N-cadherin homophilic adhesion. In …

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Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia

Young-Mee Kim, Mark A. Sanborn, Shaluah Vijeth, Priyanka Gajwani et autres

Cachexia is the wasting of skeletal muscle in cancer and is a major complication that impacts a person's quality of life. We hypothesized that cachexia is mediated by dysfunction of the vascular system, which is essential for maintaining perfusion and tempering inappropriate …

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Inhibition of β-catenin signaling by Amyloid-β in endothelial cells impairs vascular barrier integrity

Joseph W. Leasure, Thi Mai, A.V. Fogel, Pierina Danos-Diaz et autres

ABSTRACT Dysfunction of the blood-brain barrier (BBB) is emerging as a critical mediator of Alzheimer’s Disease (AD) progression and precedes the formation of large Amyloid-β (Aβ) plaques in AD patients. Maintenance of the blood brain barrier integrity by brain microvascular endothelial cells …

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Theoretical and Experimental Study on Carbodiimide Formation

Marcell Csécsi, Virág Kondor, Edina Reizer, Renáta Zsanett Boros et autres

Carbodiimides are important crosslinkers in organic synthesis and are used in the isocyanate industry as modifier additives. Therefore, the understanding of their formation is of high importance. In this work, we present a theoretical B3LYP/6-31G(d) and SMD solvent model and experimental investigation …

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FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity

Md Zahid Akhter, Pascal Yazbeck, Mohammad Tauseef, Mumtaz Anwar et autres

The mechanical environment generated through the adhesive interaction of endothelial cells (ECs) with the matrix controls nuclear tension, preventing aberrant gene synthesis and the transition from restrictive to leaky endothelium, a hallmark of acute lung injury (ALI). However, the mechanisms controlling tension …

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Matrimeres are systemic nanoscale mediators of tissue integrity and function

Koushik Debnath, Irfan Qayoom, Steven O’Donnell, Julia Ekiert et autres

Abstract Tissue barriers must be rapidly restored after injury to promote regeneration. However, the mechanism behind this process is unclear, particularly in cases where the underlying extracellular matrix is still compromised. Here, we report the discovery of matrimeres as constitutive nanoscale mediators …

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