Mumtaz Anwar

A Novel Epigenetic Mechanism of Intestinal NHE3 Gene Regulation by Histone Acetylation

Anoop Kumar, Dulari Jayawardena, Shubha Priyamvada, Mitul Patel et autres

NHE3 is an essential Na+ transporter in the intestine, contributing to diarrhea associated with inflammatory bowel disease (IBD) or intestinal infections. Nevertheless, the influence of histone acetylation on intestinal NHE3 gene expression has not yet been investigated. Various methods were employed, including …

us (code pays fourni par la source)

ERG-deficient endothelium identifies IL-8/CXCR2 axis as a therapeutic target for resolving neutrophilic lung vascular injury

V. Vigneshwaran, Vijay Avin Balaji Ragunathrao, Jagdish Chandra Joshi, Zahid Akhter et autres

Aberrant polymorphonuclear neutrophil (PMN) accumulation in tissues induces chronic vascular diseases. Endothelial cells (ECs) regulate the access of PMNs into the tissue from the blood. However, the mechanisms that prevent PMNs from being activated and accumulating in the tissue, a hallmark of …

mx, us (code pays fourni par la source)

A Single Mutation in TRPC6 Protects Mice from Acute Lung Injury by Regenerating Endothelium

Mumtaz Anwar, Vijay Avin Balaji Raghunathrao, Ruhul Amin, V. Vigneshwaran et autres

Abstract Regenerating vascular endothelium under sepsis, trauma, and viral infections is vital for promoting the resolution of inflammatory diseases such as acute lung injury (ALI). Transient receptor potential canonical (TRPC) channels mediated Ca 2+ entry compromises organ functions and survival from lung …

us (code pays fourni par la source)

RGS2 is an innate immune checkpoint for suppressing Gαq-mediated IFNγ generation and lung injury

Jagdish Chandra Joshi, Bhagwati Joshi, Cuiping Zhang, Somenath Banerjee et autres

Interferon gamma (IFNγ), a type II interferon, augments tissue inflammation following infections, leading to lethal acute lung injury (ALI), yet the mechanisms controlling IFNγ generation in the lungs remain elusive. Here, we identified regulator of G protein signaling 2 (RGS2) as a …

us, cn (code pays fourni par la source)

List of contributors

Heidi Abrahamse, Oluwakemi V. Adeleke, Adeyemi O. Adeola, John K. Ajayi et autres

Afrique du Sud, Nigéria, in, us, tr, gb (code pays fourni par la source)

A comprehensive overview of epigallocatechin gallate and its role in human osteosarcoma inhibition

Riyaz Ahmad Rather, Mumtaz Anwar, Zeenat Farooq, Vijayalakshmi Srinivasan et autres

us, in (code pays fourni par la source)

Notch transcriptional target tmtc1 maintains vascular homeostasis

Na Yoon Paik, Jacob Neethling, Mumtaz Anwar, Prerak Gupta et autres

Proper lung function requires the maintenance of a tight endothelial barrier while simultaneously permitting the exchange of macromolecules and fluids to underlying tissue. Disruption of this barrier results in an increased vascular permeability in the lungs, leading to acute lung injury. In …

us (code pays fourni par la source)

FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity

Md Zahid Akhter, Pascal Yazbeck, Mohammad Tauseef, Mumtaz Anwar et autres

The mechanical environment generated through the adhesive interaction of endothelial cells (ECs) with the matrix controls nuclear tension, preventing aberrant gene synthesis and the transition from restrictive to leaky endothelium, a hallmark of acute lung injury (ALI). However, the mechanisms controlling tension …

us (code pays fourni par la source)

Endothelial ERG programs neutrophil transcriptome for sustained anti-inflammatory vascular niche

V. Vigneshwaran, Vijay Avin Balaji Ragunathrao, Jagdish Chandra Joshi, Md Zahid Akhter et autres

Abstract Neutrophils (PMNs) reside as a marginated pool within the vasculature, ready for deployment during infection. However, how endothelial cells (ECs) control PMN extravasation and activation to strengthen tissue homeostasis remains ill-defined. Here, we found that the vascular ETS-related gene (ERG) is …

us (code pays fourni par la source)

Programming of neutrophil transcriptome by endothelial ERG maintains anti-inflammatory vascular niche in the lungs

V. Vigneshwaran, Vijay Avin BR, Jagdish Chandra Joshi, Zahid Akhter et autres

Neutrophils, the predominant blood leukocyte and first responders to the infection, reside as the marginated pool in the lungs. Vascular hyperpermeability and activation of infiltrating neutrophils is the hallmark of lethal acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, …

us (code pays fourni par la source)

Cell-Free Fetal DNA: Genesis and Clinical Utility

Mumtaz Anwar, Vijayalakshmi Srinivasan, Ajay Prakash, Zeenat Farooq et autres

us, in, Éthiopie (code pays fourni par la source)

Tension sensing by FAK governs nuclear mechanotransduction, endothelial transcriptome and fate

Md Zahid Akhter, Pascal Yazbeck, Mohammad Tauseef, Mumtaz Anwar et autres

Abstract Vascular endothelium forms a restrictive barrier to defend the underlying tissue against uncontrolled influx of circulating protein and immune cells. Mechanisms that mediate the transition from restrictive to leaky endothelium, a hallmark of tissue injury exemplified by acute lung injury (ALI), …

us (code pays fourni par la source)