Marco Straccia

Central vascular access in kidney and cancer care: devices, biomaterial strategies, and prevention of complications

Ivana Campia, Cécile Oury, Patrizio Lancellotti, Marco Straccia

Chronic kidney disease (CKD) and cancer are among the most prevalent chronic conditions that increasingly demand reliable long-term central venous access devices (CVADs), including central venous catheters (CVCs), peripherally inserted central catheters (PICCs), and implantable ports (PORTs). Despite their essential role, CVAD-related …

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NAMs without context of use slow EU adoption

Marco Straccia, Milena Mennecozzi

New approach methodologies are not a separate market or scientific category, but a heterogeneous set of methodologies whose relevance depends on a clearly defined context of use (CoU). The early definition of CoU should guide validation, qualification, and evidence generation to accelerate …

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Translational assessment instruments for preclinical to first-in-human decision-making: a scoping review

Marco Straccia, David Mawufemor Azilagbetor, Celean Camp, Guilherme S. Ferreira et autres

BACKGROUND: Preclinical evidence used to support first-in-human (FIH) decisions is often assembled through isolated assessment tools that improve individual parts of translational practice but do not preserve assumptions, uncertainty, and decision intent across discovery-to-clinic handoffs. We therefore reviewed structured translational assessment instruments …

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Health Monitoring via Wearables: Insights from Scientific Publications and Patents (2015–2024)

Ivana Campia, Fabrizio Rossi, Laura Avogaro, Amy Heather Hearn et autres

Evaluating the translational value of preclinical models: Available tools and frameworks, challenges and strategies

Francesca Pistollato, Fabia Furtmann, Marco Straccia, Marc T. Avey et autres

Recent global initiatives are accelerating the shift toward human-centric approaches, reducing reliance on animal models in preclinical research and other domains. In this changing landscape, objectively evaluating the scientific relevance and merit of research involving animal models, and assessing their translational relevance …

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Corrigendum: Lack of Helios during neural development induces adult schizophrenia-like behaviors associated with aberrant levels of the TRIF-recruiter protein WDFY1

Anna Sancho‐Balsells, Verónica Brito, Belissa Fernández, Mónica Pardo et autres

• please read through all the templates before choosing • pick the most relevant text template(s) from the following page and delete all others.• edit the text as necessary, ensuring that the original incorrect text is included for the record, please see …

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Leveraging innovative research tools to meet public health challenges: a BioMed21 workshop report

Francesca Pistollato, Fabia Furtmann, Sarah Abitbol, Marta Agostinho et autres

Promoting reusable and open methods and protocols (PRO-MaP) can improve methodological reporting in the life sciences

Sofia Batista Leite, Matthew A. Brooke, Annamaria Carusi, Andy Collings et autres

Detailed method descriptions are essential for reproducibility, research evaluation, and effective data reuse. We summarize the key recommendations for life sciences researchers and research institutions described in the European Commission PRO-MaP report.The open science movement has heavily focused on Open Access publications, …

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W54. “MINDDS-CONNECT” – FEDERATED DATA SHARING PLATFORM FOR NEURODEVELOPMENTAL DISORDERS AND RARE GENETIC MUTATIONS

Marina M. Mihaljevic, Benjamin Huremagic, Janet C Harwood, Paola Jorge et autres

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Promoting Reusable and Open Methods and Protocols (PRO-MaP): Draft recommendations to improve methodological clarity in life sciences publications

Sofia Batista Leite, Matthew Brooke, Annamaria Carusi, Andy Collings et autres

Detailed, accessible methods are essential for reproducibility, trust in science and scientific advancement; yet, many studies suggest that the reporting of methodological details in life sciences research publications is often incomplete. This may be due to a lack of incentives or reporting …

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Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto–Placental Organ-on-Chip Platform

Michaela Luconi, Miguel Angel Sogorb, Udo Rudolf Markert, Emilio Benfenati et autres

Developmental toxicity testing urgently requires the implementation of human-relevant new approach methodologies (NAMs) that better recapitulate the peculiar nature of human physiology during pregnancy, especially the placenta and the maternal/fetal interface, which represent a key stage for human lifelong health. Fit-for-purpose NAMs …

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Human-based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State-of-the-art with a Feto-placental Organ-on-a-chip Platform

Michaela Luconi, Miguel Angel Sogorb, Udo Rudolf Markert, Emilio Benfenati et autres

Developmental toxicity testing urgently requires the implementation of human relevant new approach methodologies (NAMs) that better recapitulate the peculiar nature of human physiology during pregnancy, especially the placenta and the maternal/fetal interface, which represent a key stage for the human lifelong health. …

it, es, de, at (code pays fourni par la source)